+ 2 Ultra Rapid Metabolizer - Testosterone - Consequences?
Apologies if this is in the wrong forum.
Some of you may be aware that certain people process various drugs and compounds differently from one another. I was given a pharmacogenetics test by my doctor and discovered that I am an ultra rapid metabolizer of the CYP2C19 enzyme which processes a lot of different things. Proton pump inhibitors, benzodiazepines, cannabinoids, fatty acids are all in and out of my system before you can blink. I have to double the dose of Pantaprozole at minimum to get relief for acid reflux. I cannot get high from thc edibles, and I also process codeine and diazepam specifically so quickly as to not even feel the effects unless I take triple the dose.
Well, apparently this enzyme also processes endogenous steroid hormones and therefore also exogenous hormones. Here is a link to the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426391/
So my question is this. Obviously I am going to have to do a lot of playing around and get loads of bloodwork done to really be able to know, but since I have to significantly increase the dose on all the other medications processed by CYP2C19, would it potentially make sense to significantly increase my testosterone dose as well? I'm hoping someone with a more scientific background can chime in. Curious to know if anyone else also has this and what effects have been noticed and what the consequences might be. However upon closer examination less than 20% of exogenous testosterone is processed by cyp2c19 so I am guessing the effect is not significant. Still interested in people's thoughts!
- Bookmark
- 2
- 0
New update - "Since CYP2C19*17 defines an ultra rapid metabolizer phenotype we suggest that an increased catabolism of estrogens by CYP2C19 may lead to decreased estrogen levels"
This also tracks. Wonder if this is why im so sensitive to the AI effects of EQ. If I take test:eq at a 2:1 ratio, I don't need any add at all. I was running 1000mg test, 500mg EQ, 300 npp and no AI needed.
https://pubmed.ncbi.nlm.nih.gov/18521743/
My concern would be so you still get effected negatively the same as someone else would or are you effected at a reduced rate because your absorbing at a reduced rate. Like if you need 3x amount of an opiate to feel it, would you also need 3x the amount to overdose? And with hormones, if you need double the amount of test to get the same results are you having twice the negative sides or just the normal amount because your just getting the normal amount of benefits from it even tho it’s double the dose. I did a really bad job trying to explain that but I hope you get what I mean
Damn, I didn't even think of that. I totally get what you're saying. I guess the only way to really know would be to do bloodwork consistently and see if there are elevated markers. But this would make sense with how I respond to oral superdrol - I'm able to take 20mg for 6 weeks with very manageable side effects. Usually only a little raised BP and acid reflux. I've gotten bloodwork done at 4 weeks on superdrol, and had only slightly elevated cholesterol, normal liver values, and slightly raised BP.
As far as opiates go, all I know is that whenever I did get an effect, it would be gone within 2-3 hours tops. So I don't really bother taking them anymore.
So I’d say that you probably do have less side effects then someone else would at that dose, at least for some substances. Like superdrol, I can’t take it for more then like one day or two unless I like microdose it. So if 10 mgs makes me feel like shit and 50 mg makes you feel like shit, I’d bet we’d have similar negative effects on organs and stuff but your taking 5 times as much. But with some substances you may have to be careful because you may be getting 100% of the toxicity or wear and tear but only 50% of the benefits. I have no knowledge on this topic to back it up but it’s just a concern I would have if I had this mutation. I could be completely wrong and you may only be affected by what your absorbing idk
Interesting to know of this, thank you
I would like to know if others are experiencing this condition too. Thanks for posting.
So you and I just was chatting about this, this is a real condition that affects some people. One long time eroids member had several testosterone blood tests in the past that scored badly. At first he thought certain brands were underdosed but eventually he realized through trial and error that he was a fast metabolizer. Like him, in your case you probably would benefit more from a longer acting test ester such as undecanoate. You could also try more pins like you mentioned but not sure how that will work out.
So...I have essentially been underdosing myself by a lot this entire time. LMFAO --
I have to laugh cause otherwise...wowwww. At least I found out before this next blast --
Now that's funny...true but funny
My bad! I didn't see your response in the other thread yet. Thank you! I didn't think about the longer acting ester, but I have some test 400 coming that is mostly undecanoate (200 undec, 100 cyp, 100 tpp/tp/iso) so hopefully that should help.
It all makes a lot of sense now...
No you're good, wasn't meant to come off like that. I figured you didn't see other comment that's all. But yea I think I know what testosterone mix you're talking about. I thought about trying that same testosterone mix.