giardap's picture
giardap
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+ 34 Why I don't use Tren anymore, and never will again

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The dogs in the street know that Tren is a psycho.

Sure, there are outliers who can eat it all day long without suffering the way you or I do, but they are few and far between. When I was young, I could use it at high doses without getting crazy, and I did, for years on and off. But it has taken it's toll on my mind, along with other things. Now I suffer all of the sterotypical sides, moreso with tren a due to its high peak, but also with tren e. From heyday high doses, I now cannot even handle 100mg Tren E pw without succumbing to high BP, flipped lipids, and cognitive annihilation. You name it; my bird is a cnut, the world is a wanker, and I will smash your jaw around the back of your filthy head etc. etc. Disgusting really.

Some of you will remember the study from about 3 years back, many wont, and lot's wont care. But, you should.

Some very smart chappies out of China's Shandong University studied rats to see what Tren was doing in the brain. Now before you cry foul of the poor little rats, remember that their endo system is more or less the same as ours. Mammals are good like that, generally speaking.
Anyway; they discovered that beta amyloid plaques were accumulating in a very significant way in the brain. They realised it was plaque 42 which the brain doctors firmly accuse of being a leading cause of Alzheimer's Disease.

Shiiiiiiit..... right?

Yeah but the die hard won't give a crap and sure we have all been there at some point. But, the study went further. It actually figure out that it is the standard mediation of effects via the androgen receptor that caused it. They also realised there is significant neuronal damage taking place..... wait for it......it KILLS brain cells too....
OH FUCK!

So after years of the strength gains, the slow muscle building gains, and the fat burning magic of tren

I realise something isn't right. MY brain does not work the way it did before. There are many factors for that, but when it is really off it feels the way it does on tren (the sterotypical bad effects). So... anecdotally speaking, damage has been done.

So, I cannot handle it, but it also kills brain cells and is gradually potentially causing Alzheimer's.
I'm out...... for good

There is hope though

Alzheiner's is an area where there is massive scientific interest and significant investment. Recent studies showing new proteins can clear the plaques and prevent more from forming. You might also want to take a look at this study, courtesy of Carlos Danger: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169155. This is far more accessible than the protein which is very far from being realised as any sort of treatment.

So, it's up to you, as always.

What you do is your own business and some of us are adults here on eroids too! But for me, even though there is hope down the line for some of the damage tren causes, I dont want to end up in a position where I have already forgotten about it! I also don't want to keep killing brain cells, nor do I want to feel the cognitive destruction that tren causes anymore. It accumulates with time, and retrospectively I can swear to you that it is not worth it.

References
http://www.ergo-log.com/trenbolone-may-increase-alzheimer-s-risk.html - I have the full study, if anyone wants to read it, it is eye opening, I can email it to your anon email addey, just PM me.
https://www.sciencealert.com/new-protein-injection-reverses-alzheimer-s-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169155

EDITS
Edited to add the following link from Carlos Danger: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169155
Edited to add, from BJ: Mineral volcanic water for Alzheimer’s: https://pubmed.ncbi.nlm.nih.gov/22976072/

dextetherdog's picture

Have very close person to me that suffers an Alzheiner’s disease and it’s very sad to watch what it does to this person (nothing to do with BB or PEDs)
But if studies show that Tren has a potential of causing this shit, I choose to stay away from it.
Thanks for sharing this with us, + from me all day long man

giardap's picture

Sorry to hear about that dexter. Check out exogenous ketones for him/her. Depending on where they are at, it might help a little, some interesting work being done in that area.

dextetherdog's picture

Thanks man, from what we have been researching over the last couple of years, there’s nothing obviously that can heal this, more like slow down the process.
But I’ll go through again to check if there’s something new. Thanks again for sharing this man!!!

giardap's picture

Exactly. Look after the mind and positivity comes with that.

addicted.to.pain's picture

I have never used Tren myself so I cant make any truly contributory remarks for or against Tren, But I trust your judgment and appreciate your candor on the subject . I feel I can make an informed decision in the future concerning Tren.

I have enjoyed the OP right up and the comments thoroughly though, reading through all the reply's and comments impresses on me the seriousness of the compound, its insane how much unnecessary Tren use I see on these boards.

giardap's picture

Well there you have it. This is the very point of the subject; get real information out here and with a bit of luck people will take consideration of how serious a decision it is.
Cheers atp ,respect.

Carlos Danger's picture

Very interesting! So it mentions that it was the androgen inside of tren that was culprit would we hypothesize that all androgens can play a part? Or is it simply the pure strength of the androgen in Tren that makes tren so much worse? 500/500 ratio is crazy high. It also mentioned the combination of Androgen and DHT made it even worse. That’s fucked if you’re running a Test Tren Mast stack!!

Any idea if the reversal protein is being made available via research chem/peptide? This is potentially a game changer bro. In your readings were you able to make any sense one way or the other what type of dosages would or could be permissible for a human? Or am I reading it correctly that even a tiny dosage would or could be damaging and potentially catostrophic?

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SL's picture

Good point

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giardap's picture

Well tren is the androgen and attaches to AR's in the brain. But it mentions that testosterone actually has a protective action on neurons, but when tren is there it resists the testo protection. It also acts on estrogen receptors in those neurons. So it hits it up via 2 avenues and then jacks up plaque production.
So it is the compound, but yes given its higher binding affinity, it simply acts first (triple whammy).

TMT - yep! And what do all the kiddies load up on? I mean those under 25 who havent finished brain development yet, killing cells before they have even matured. Not to mention the rest of us of course.

They are a long way off on the proteins. Nowhere near human trials because apparently it can cause anaphylactic shock in those with allergies and can speed up neuron cell death in older animals and all sorts of other nonsense! So it looks like, from what I read today, that possibly upregulating natural production of the protein might be an avenue, but as usual.... "further research are needed"

On the doses, the equivalent human dose was .85mg per kg. So for me that is .85mg*110 =93.5mg. They administered 6 doses over 2 days. So, its similar to a normal front load you might even say! Poor rats!
Honestly, I cannot say if the same level of damage translates to humans, but given the cognitive problems I experience myself even at 100mg pw these days.... and that behavioural issues show long after damage is done... I can only assume it is a similar level of damage. Pretty much means no dose is safe from what I see.

Carlos Danger's picture

In your readings was there ever any mention of serritonin? I’ve been adding tryptophan and Gaba to my tren stacks and that really seems to help. Haven’t run tren in a couple of years so it’s been a while but that combo along with some added fats like real butter (added cholesterol) helped out when I felt edgey.
- I found this and thought it could be an added talking point
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169155/

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giardap's picture

Thats way more interesting on the plaque front than the protein, I reckon.
No I didnt really get into it in that regard with tren. Although, what you are saying and showing here makes a lot of sense. The only experience I have myself is with SSRI's while on a tren run and the bad tren sides were worse than ever. But that said and for transparency, I am one of those people that SSRI's do not work for re: depression for example. I couldnt speak for the plaques though, but that seems pretty damned conclusive, what you linked to there. Really interesting.

Carlos Danger's picture

It’s a great topic you brought up bro. I’m glad people get a chance to read about this who might never have known. Way to many sheep out here nowadays. Though Greg and Popeboy would prefer goats;)

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giardap's picture

Goats are wayyyy more versatile and the lads know it lol

Jayzgainz's picture

Ehh, I dont know man, sheep are pretty fuzzy and they really enjoy being shorn.

https://youtu.be/chhUG53PdSI

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giardap's picture

AAAAAAAAAND we have a winner LOL
Ah man, I havent laughed that hard in a while! Brilliant!!

CBBurrr's picture

That was pretty fucking twisted. worth clicking on for sure

johnmarshall12's picture

Sorry you had such bad experiences! This is a well written article. However most eroids members are aware of the risks and the rewards; so it's a personal choice.

Each user has to make that decision. I feel sorry for the hapless people who don't know the risks and think Tren is the Magic toy to Superdom. It may be, but at risk and cost in realtime.

Sad are those who stay on Tren for very long periods of time. Yes it feel great to have a rock hard body, but if it's going to make you sick...well you know.

So, to those who will use then, keep cycles short and don't go nuts on dosage!

giardap's picture

Hi John, actually the reality is very different... considering that the study is a mere 3 years old and that the overwhelming majority of eroids members I interact with do not have access to scientific journals let alone read abstracts, I think it is extremely safe to say that a massive amount of eroids members are absolutely not aware of the risks of neuronal toxicity and cell apoptosis. Hence the article, in the hope that the scientific evidence coupled with the well known side effects will sway some to make better personal choices.

Also worth noting that the point of the info is to advise people not to use tren, and not; not to "go nuts on dosage" whilst giving cycle advise to those who will use it. If you read the actual study you will understand why. Although the reason is noted in comments below.

Agreed on aesthetics vs getting sick. Nothing is worth it.

giardap's picture

And there you have it. Keeping things as simple as possible is everything. Education makes these things easy to walk away from.
Cheers fella. +'s

wanted's picture

My wife thinks i have selective memory loss
already in my 40's. I already have to have post it notes all over the dabm house

CBBurrr's picture

Helps to have a wife that remembers shit for you

giardap's picture

Getting old sucks at the best of times, never mind that lol

Faz's picture

After some terrible advice from a friend I thought i could trust who competed regularly in the UK, my first two cycles were test + tri-tren then test + tren e.
It wasn't till my third cycle(not listening to him) I realised how much fun a cycle can actually be.
I will never use tren again. Test, provion an sometimes var for me from now on.
It's an amazing compound that only needs to be used by advanced, dedicated bodybuilders that can use it to its full potential in my opinion.

giardap's picture

There is a big number of vets on here Faz who will advocate simple test plus provi cycles all day long. That speaks for itself. Right on man.

Im not picking on him or anything, but even at that advanced pro level it can go wrong. Dallas McCarver was loaded with test and tren, found in his autopsy. Gotta wonder how much heart damage was due to the tren.

Faz's picture

Yeah mate, it was reading the vets posts on here that leant me towards test provi cycles.
I only cycle once a year so I've no need for 5 compound cycles
It's a shame what happened to Dallas, it's crazy what they think they need to use to compete at his level. I respect their dedication an commitment but life's too good to cut it short like that.

press1's picture

Let's just remember though that these guys aren't forced into competing in Mr Olympia - Its what they choose and want to do with their life. Its not actually the steroids that cause them to colapse on stage either such as high levels of test or tren, but the levels of dehydration/carb depletion they are at caused by the massive amounts of durietics in them to remove every last drop of water and the levels of fat burners causing them to run at insane body temperatures. They are virtually on the edge of what the human body can take in those final hours...

Faz's picture

Completely agree mate

giardap's picture

x2
yeah for sure man, there is a bigger picture with those lads

giardap's picture

Yeah man absolutely. Remember the time he collapsed on stage? I mean... that was the time for serious emergency intervention. Such a shame, right

giardap's picture

Ha, well here is a couple of +'s back for ya!!! - Id say there have been more people banned from eroids because of tren than anything else!!

Goose24's picture

lol probably why they give it to cattle and not humans. Cattle have a short life expectancy and don't need a brain lol.

giardap's picture

Oh yes!

press1's picture

Now that's someone with a Serious set of bolloc** on them....

heavymetalmonsterD's picture

Jacked af Lmaooo

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GrowMore's picture

I hear you giardap, I’ve been having a similar experience recently. Nice contribution

Nearly forgot If I check my search history after a Tren blast it makes me shudder, yet another reason not to run it.

giardap's picture

Murder porn?!!! LOL

GrowMore's picture

Well beyond that bro

CBBurrr's picture

Uh oh..
Girls and cups

GrowMore's picture

2 and 1

giardap's picture

Sweet Jesus!!!

glowinthedark's picture

If someone has time to investigate the topic further I'm curious if the build up in Alzheimer's cells clears after stopping tren and also if using a racetam called noopept would prevent it? I use the product for memory and focus it's a prescription for Alzheimer's in Russia, research chemical in other places

giardap's picture

Re: tren, I would imagine natural clearing happens but there would be a significant buildup. These animals were treated for 48 hours with only a minuscule dose equivalent to .85mg/kg - thats nothing compared to any BB dose. The buildup was massive.

However the most concerning thing is that it directly causes apoptosis of neuronal cells, so, a serious form of degradation happens. This said, I would say that the most seriously at risk of Alz's re: the amyloid plaques are those with existing risk markers for Alz's disease.

I looked at that pep a while back (a relation has Alz, so was researching). Honestly, I doubt it. It lowers toxicity but I dont think it removes the plaques. It certainly wouldnt prevent neuronal cell death imho.

glowinthedark's picture

https://www.sciencealert.com/new-protein-injection-reverses-alzheimer-s-...

Looks like they made a drug that removes the plaques maybe there's hope

giardap's picture

Yep, thats in the post already brother! Didnt you read it?!!!

Goose24's picture

I'm guessing he's currently on a tren cycle lol