Pyramining went out in the 2000's that is old school thinking and is not practical. The science says this, you can front load (a heavy dose to introduce it into your body quicker.) But after that it should be kept at a level that keeps plasma levels as even as possible. Say you take a propinate ester to keep plasma levels stable you must take a shot at least every other day. Now a longer ester should be taken twice a week to keep levels stable. That is what science says "NOW" tomorrow might be different but for now keep levels as stable as possible.