posted Thu, 07/25/2024 - 16:36
3682
+ 1 Receptors
ad
How can you tel if you need to take a break in the sense that your receptors aren’t functioning the way they used to function. With any drug you build a tolerance how exactly does that pertain to gear. I was sitting around and overthinking as usual and started thinking about how the body builds a tolerance to gear and how do I reverse this if this is the case. You know how we get, we always think we need more or we aren’t seeing the results we expect. Expectations vs reality.
- Bookmark
- 1
- 0
The receptors actually up regulate, so you have actually more receptors. With other drugs what happens is you start with let’s say ten receptors and you fill them ever time you take that drug so the drug works, well eventually the body will make more so now you have fifteen receptors but only take enough of the drug to fill ten of the receptors, so you must increase the dose to get the same effect.
So tolerance is usually a side effect of up regulation not down regulation, I’m sure there some drugs and receptors that do in fact down regulate and need resetting but steroids don’t work that way.
Also I’m not positive about steroids working in this exact fashion, I know they up regulate but I’m not positive that this is the cause of the need to increase doseage.
It’s not the receptors. Your receptors upregulate when using gear. Your results diminishing are directly related to myostatin. When you build muscle fast myostatin levels will raise and usually after 16 weeks myostatin levels will start to gradually go down. I was just reading study after study in this. Taking a break is for health reasons. You need to give your body a rest. CNS needs a rest. Joints need a rest. Your brain needs a rest etc.
anvilPlease link the study you are speaking of. Here is a meta study, the results are weight training causes lowered myostatin levels, so if you take a break the opposite affect of what you have said here occurs.
https://www.sciencedirect.com/science/article/abs/pii/S003193842300197X#....
Yes I personally feel the joints, CNS and just overall the body needs a rest. Now the myostatin thing is somewhat disputed.
I always thought the receptor theory was a wives tale.
AK80Might be a placebo. That blood work will always come back the same. You probably got used to feeling better. Try different injection sites. Slin pins are amazing for that.
anvilGood topic I love a spirited debate @Musclemem
Thanks Anvil! It’s even better when knowledgeable guys like you all who contributed on this thread.
Time on cycle + pct = time off. Receptors stay fresh as its their job to do so. But your body in whole can only grow so much at a given time. Which is why its a cycle.
anvilYes says the books written in the 80-90s. I wish you'd explain the reasoning on your posts , honestly there most of the are partial thoughts and based on that I'm unsure why you post anything. I know this comes off rude but I just don't get your input and I wish too. Time on cycle + pct= time off what does that mean please explain.
Ok. Kindergarden speech for the turds here that cannot read.
Time on cycle(as stated) + time on pct(as stated) = time off cycle(as stated). Its called a cycle and not a permanent blast. Myostatin raises and halts gains. Cholesterol turns ugly and noone wants a stroke or heart attack. Liver enzymes raise. Kidney function turns. Cns, the central nervous system for the unknowing, can only go so far. I can go on but you wouldnt comprehend.
I think reasonable and spirited debate is amazing and great for the forums, but getting instantly defensive when being questioned instead of articulating a point comes off as brash and childish. Your first and last sentence take away from anything you said in between.
@Jockstrap I wasn't going to say anything but @chad p @23Sparta @anvil are solid guys and I mean that ya jock itch. All those guys can teach and bring something to the table like we all do. Point is best you watch yourself before these guys run that train on ya!!! Choo choo!!!!
Just trying to look out for you
I think I can, I think I can, I think I can
Yeah, exactly…. “old school” linear cycle design and philosophy in general, create situations where one has to stop because their health markers are so fucked off from the bad advice they took on how to safely/properly run gear
Myostatin is so debunked and such a non issue it’s laughable when someone brings it up.
https://youtu.be/nALG4Xqjvrk?si=U-c3D9NqxwE0GEF7
anvilI enjoy living in the past and ignoring success to recycle old crap. I am about to break my jug of mega mass 4000 because 800 grams of sugar carbs will get me a lean bulk.
Mega Mass 4000!!! Jesus christ talk about reminiscing in the Good 'Ole days eh. Along with Cybergenics Systems and Celltech which all amazingly seemed to give gains like people were on a cycle of Test, Deca and DBol!! LMFAO Or 'maybe' its because they were ...... Hell we all bought into it though
anvilOh yeah me and a couple of friends split the price to get it. It was insane training schedule.
My brother, whose pics @Jockstrap I posted, is about to enter the 24th week of his first cycle. We never pulled the plug, why? That badass mother fucker is still growing, and his bloods aren’t crashed. Past week 16 is when his most impressive gains occurred. If he’d of stopped right there, the majority of what you saw in that last pic would have been left on the table. Facts
anvilNah you aren't allowed to post his stuff my brother, Jockstrap said so.
I love to hear it. I just don't want him catching me, maybe have this fool give him advice...
Just like I was doing well on a cruise, stayed on extra few weeks, felt great. But now I am back in fully!
His next two vials will be sterile oil before he catches either one of us
anvilFax , just the fax.
Lmao, cultivate that malto mass big bro
As long as you don’t dump out your tub of “Hot Stuff” you’ll be fine.
They don't know anything about Hot Stuff... probably don't have a clue lol
anvilLMAO Drex I typed that first but I was like the mega mass made everyone fat hotstuff at least had dbol in it lol
Those companies made millions off of us. My favorite was the old Twinlab amino fuel, citrus flavor. Stuff tasted like orange, lemon, pineapple, and dehydrated piss lmao
Nah the original Hott Stuff was legendary and for sure spiked. Awhile back I posted a forum on it
Need a good thread to talk about all that bullshit that was popular late 1980s and the 1990s lol
I got something for ya. Legendary times for sure
Wasn’t there oral test in Ted Arcidi’s line of products? I remember hearing that, you know, about 100 years ago lol
Man you went wayyy back lol! I don't remember that but it wouldn't surprise me if he did. What was that supplement called? You remember? ...First man to ever bench press 700 pounds pretty much raw. I gotta say he got me started with that lift. I didn't know he had a supplement line.
EDIT: Ole Ted set that record twice. I think he came out of retirement in 90 and set the world record again. I believe in Hawaii was the first or second time he set record.
anvilSteroids are often used in patterns called "cycling." This involves taking multiple doses of steroids over a specific period of time, stopping for a period, and starting again.
TRT is not done like this, pros do not do this, and I don't claim to be either, but using "dubious extrapolation" you can see a clear path to success. Scale what they do so successfully to your needs.
I do not subscribe to "cycles" and I would only advise this way if your goals are to be a gym bruh with an average build, which I am sure you are jocky my boy. You can play hormone peak/valley all your life exposing yourself to the same drugs I do and getting less in return.
I go by bloodwork as should even little guys like you LoL .
I am all in range, I will state to be transparent I had some BP issues in the past but I found a great combo that is keeping me 120/69 even on going full bore. That was my limiting factor but with that resolved I see no reason except bro science to be mediocre. There is nothing wrong with be health conscious but if you are getting blood work then you know your limits.
Little guys like you …. Pmsl your hilarious sometimes bro
tread-m0 #GURU Leroids
12Y ago
I'm not sure how many studies there are on this because you would have to pueposely damage some people to get your answers..lol. I do know several people just here alone under 30 and on trt with test below 200 from abuse. Frankie has told his story openly so I don't mind mentioning him either. In fairness, I help a few people with very low test at very yyoung ages that never did gear in thei life so it can happen with or without abuse but I have seen enougbh abusers witbh damaged levels from use to know it is real and it is in my higher numbers than those who are damaged with no use prvious to the low number. The time on time off thing is a good number because you have to think first , you natty does not really recover fully for about 8 weeks post last pin. so if someone is starting the new cycle at the end of every pct run 4 weeks on average before they made full recoveriy that actually likely more dangerous thn blast and cruise in terms of potential to damage natty healthy numbers. I can't give you much more other than once recovered in 8 weeks the body has time to normalize under current suggested protocols and that normalization may he the healthy way to go.
@anvil and @jock itch Well guess I'm out -dated or stubborn or maybe both. I don't cruise but come off completely and pct. It sux but yeah I'm stubborn and use to doing it this way. Eventually I'll try trt. If you really think about it though it takes the body awhile to get back in homeostasis or normal. Alot of guys think a month and they're good..not so fast my friend. I was just having a conversation with a guy yesterday about this. He brings up old methods and new methods s lol
anvilI respect your thought process and you know what's best for you. You have always known how I feel, if you feel better coming off then do so. We both know that receptors don't reset or refresh or whatever, and myostatin doesn't need it either. You have the knowledge, and you are basing it off what's best for you. And if you are happy with the gains you have made then everything is good.
Jockstrap doesn't have the knowledge or the understanding and his posts are terrible. They lack explanation and are more like barbs then they are answering the questions that the person is asking.
I appreciate that brother I do. Yeah it works but I understand that I may be leaving gains on the table. So yeah it has its pluses and minuses but that's just the way it is right? It sux and you feel horrible, I'm sure if I did trt things would probably be easier and or different. And I agree with you about receptors upregulating not down regulating. And yeah my method may be best for me but not for the next man but I'm sure in the future I'll change a few things in regards to this. Lol but I'm still out dated! Guess for me it has alot to do with being able to have kids too
anvilAwesome another 12 yo post cool. We haven't learned anything since then!
He means if you run a cycle for 16 weeks, pct takes 6 more weeks, then you should have a down time of 22 weeks to “reset” everything.
Definitely not a modality the professional body builders prescribe to, otherwise they’d compete once every 2-3 years.
anvilThat doesn't apply to the real ones SoS..that is like one good run per year? Not recommended.
Yea so either a bulk cycle or cut cycle. You don’t get both lol. But hey I cruise so this doesn’t apply to me
anvilNo doubt brother !
Lol that damn anvil....shots fired..shots fired!!!! Man down man down!!
anvilI'm not actually trying to be a turd here. I just don't get this guy or what he posts. My body can only grow so much at given time? What's that related to, like I'm 5 11 at 240 whatever x age = how much I grow + gear. What is that statement . You grow when you are doing everything correct for yourself. I mean without explaining why he says what he says how is it helpful to this topic?
Lol you're killing me man. But yeah gotta expound or explain a bit sometimes so I agree. He's down so somebody call the damn paramedics!!!
It’s a very fair question. Testosterone gets lumped into the “drug” category, which technically it is, but it’s a hormonal treatment. As far as shutdown, even the worst heroin addicts opioid receptors function, it’s just that a physical tolerance has built up and it takes more of the drug to achieve the analgesic effect, hormones are a different ball game. It’s another conversation, but also why I’m not a fan of SARMs. Test is best.
anvilModern science has disproven this, and in fact you get more receptor density which allows more uptake. Increasing food, training intensity , then gear is how to over come a plateau.
Was just about to say this I'd like see researsch on the whole receptor not working properly bullshit. The biggest problem isn't receptors, it's myostatin. Thats why we need time off or a period of cruising (at trt levels) if one does blasting and cruising.
We can't compare humans to cattle but just take a look at those steer that have been given myostatin inhibitor meds. Unbelievable ...u can see damn near every muscle fiber