Rosschestzip's picture
Rosschestzip
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liver toxicity

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This may be a question no one has an answer too, I couldn't seem to find an answer anywhere. So we all know oral steroids can cause liver damage but does anyone know how severe it is compared to something like alcohol. Is their hepatoxicity similar to that of alcohol or do you guys think its much worse? Any input or opinion would be appreciated, thanks

BFG's picture

Metabolization processes are different between the two compounds and produce different byproducts, but I'd imagine liver working down a substance commonly found in nature, such as alcohol, is less taxing than breaking down a designer molecule.

ONESICK's picture

I'm not super big on orals. A doctor fucked me up once years ago after a surgery. I forget which but prescribed me an oral to help with inflammation. After a couple weeks or so I went to do some bloodwork and my liver enzymes were super high. I was wondering why I was feeling like shit. Apparently he fucked up the dosing and I had to come off asap. Was not fun. Plus I don't really drink and when I do it'll be like 2 or 3 at most.

Makwa's picture

Probably methly prednisolone. Just finished a course of it a month or so ago and felt like I was taking SD. Lethargic, couldn't sleep and overall feeling like crap. Took nearly a week after I finished it to start feeling somewhat normal.

ONESICK's picture

I'm pretty sure that's what it was. Dude it was like I had the flu. I was confused why I felt worse lol. Ever since I've been taking it easy with anything oral.

Makwa's picture

I can have a drink or two and my liver cleanes it up in a couple hours and is good to go. I run var for 8wks and my liver never gets a break. The liver is resilient but can only take so much for so long. Alcohol is metabolized much quicker than orals so my initial assumption is that it is not quite as toxic, but it is all relative. A liter of whisky/d is a lot different then 1oz so there alot of variables that would need to be standardized to really make a valid comparison. Just enjoy in moderation.

Rosschestzip's picture

Thats a really good point, taking orals are probably taxing the liver 24/7 were as drinking is just for a short time after the drink is consumed,

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press1's picture

I believe this to be totally true, once the drink has gone through it then its pretty much over with. But when you start looking at active half lives of orals and some oils thats where the damage and strain is taking place.

Makwa's picture

SD really comes to mind. Able to make two complete passes through the liver. 7 days at 10mg/d and I feel like death walked over me.

press1's picture

I think in a way its a good thing that Superdrol is so hard to run - because the stuff is so damn effective. If it didn't feel so rough then tonnes more people would run it for longer durations. Amazing it was once legal to buy like M1T.

Makwa's picture

You know it is weird, I had tried it back in the day when it was sold as a SARM and it never affected me like it does now. Maybe my age has something to do with it now.

Rosschestzip's picture

I tried the injectable one and I felt like garbage almost immediately, i could hardly workout, haven't touched it again and dont plan on it. I also read a study about guys with liver damage from orals and I believe all of them had been taking superdrol

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Makwa's picture

Inj SD has the same affect on me as the oral. This whole BS about inj orals being less liver toxic is just that, BS. They still have to pass through the liver regardless if injected or oral.

press1's picture

I was having this discussion with Catalyst the other day also, I think its more as we get older the less willing we are to feel like shit to get the progression. You figure out over time the cycles you feel the best and healthiest on, so you use those as a benchmark as to how you want to feel 24hrs a day. As soon as you are on something toxic you are more than aware of what its steadily doing to you internally and just don't have as much desire to tolerate it anymore.

Mac12769's picture

Absolutely. Since I’ve starting this journey, I’ve become much more “in tune” to what my body tells me. Same goes with the compounds. I pay attention as soon as something is off with me and not “expected”.

Makwa's picture

That is also why it is good to only run 1 new compound at a time so you have better chance of isolating the problem and correcting it.

Mac12769's picture

Lol. You must have been in my truck during the ride to town. At the DR office, waiting to chat and get some pre-labs done. You and Press both in my ears….

Diesel77's picture

Lookup: NAFLD. Non Alcoholic Fatty Liver Disease. Also check through link below, various different articles regarding oral AAS/hepatotoxicity.

https://pubmed.ncbi.nlm.nih.gov/29521706/

Rosschestzip's picture

Thanks I havent really found anything concrete looking through those articles other then yes they are indeed toxic and what effects they are having on the liver but it just doesn't seem like something that is quantifiable to be able to compare it to alcohol but I haven't looked into NAFLD yet. idk if im just a big idiot and everyone else knows the answer but me but ill have to look into the NAFLD. Some of the related articles on AAS on pubmed are pretty interesting to read through, i definitely will have some reading to do.

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press1's picture

Going back over 10 years ago now I was an alcoholic, 1 litre of Vodka everyday was pretty much the standard. Not once did I ever have any liver or stomach pains though, have to go to the hospital or doctors due to being or feeling ill with it etc and I did it everyday for over 15 years. However on trenbolone and Dbol I got steroid induced Hepatitis of the liver and the pain that resulted was indescribable. It was a complete shock to me as I had read so many things online saying steroids are overplayed in that area and aren't that dangerous, tren doesn't damage the liver, Anadrol 50 isn't that harsh etc etc. Obviously doses used and time on them will always play a part, but never underestimate the damage they can cause. Always make sure you take protection supplements as they are invaluable to your health.

Diesel77's picture

It could be that the years of pre existing alcohol abuse had already done some damage to the liver, and the gear just was the final tipping point and stressed it to no avail, but damage was already done a bit with the alcohol consumption going on for 15 years. As there are stages to liver cirrhosis etc from no symptoms to eventually showing some. The body itself does warn us, from overall not feeling well, to yellowing of eyes and skin (jaundice) to overly distended bellies that are very apparent with extreme cases of alcoholism. Not exactly saying that's the definitive root, just simply voicing thoughts and might be completely off, I'm not a doctor, however I do agree, anything in excess ends up doing more harm than good....in all aspects.

press1's picture

I had blood tests about 6 months after quitting drinking to check my liver and they came back fine.