I have been doing a lot of research lately on IGF and one interesting tidbit I came across was the potential that IGF has to make you a better responder to AAS. You can run less AAS and get more bang for your buck. This would seem particularly useful for those of us who have been running cycles for a long time and seem or think that we need to up the dose or increase the stack to get desired results, or even worse we hardly seem to grow anymore. Now what I am reading is that IGF , for lack of a better term, resets your sensitivity to AAS. This may be overstating it a bit but you can basically get back to newbie gains with just running a simple cycle again or with lower doses than what you normally would need.

From what I could piece together from all of the scientific jargon leading up to this is due to the effect that IGF has on the myoblasts within your cells. Apparently what happens is that IGF fuses the myoblasts in your existing cells which then donate their nuclei to cell and hence more myonucleii become present in the cell. These myonculeii are the protein synthesis mechanism within a cell so the more of them you have in a cell the greater the ability that cell has to regenerate protein, i.e. grow. Now, AAS are what stimulate the myonucleii and make them hyperactive so the more myonucleii we can have in a cell the better we will respond to AAS. By increasing the mynucleii we are now more responsive to AAS making it easier to build muscle. Hopefully someone with a little more knowledge on this could shed some more light on it but it sure seems like an interesting effect of IGF that no one really seems to talk about. It all seems to be about hyperplasia with IGF but I found this to be of great interest also.