DBolPin's picture
DBolPin
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191aa VS 192aa

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I have seen some debates on this subject throughout the forum.I really believe this is a great debate.The reason why?There is no conclusive answer.In my opinion,I don't think it really matters.They are both synthetic so they are both foreign substances.Does anyone have any information to suggest that we should be using 191aa instead of 192aa? .4 percent in 1 study built up antibodies.I don't believe that study could even confirm that it the 192aa was even responsible.

Lilbear's picture

I read on the FDA website that 191 over 192 is better just because your body over time will produce an antibody for 192.

That one extra molecule can trigger a reaction that your body will attack by creating and antibody for it.

Twistedsteel's picture

The reason is that 191aa is the exact sequence that our pituitary gland produces not 192 so using 192aa your body will definitely for antibodies I don't know where you heard that 192 only formed antibodies in .4 percent because that Is dead wrong even real 191aa people formed antibodies more than.4% 192 only mimics the hormone that humans produce so yeah it would be okay for a short period but anything over 4 months of use and you can pretty much gaurantee that your body has formed antibodies and with 191aa being exactly what we produce gives you a lot less chance of forming antibodies as long as it's pure hgh and no low purity or even medium purity.. When taking hgh especially long term use you must stick to high purity high grade brands

HailRazor's picture

I guess it depends on what UGL GH brand is being inserted into my Street Pharma analogy. Smile But yea, X , Molly, Thizzles my Nizzles....isn't always MDMA and most likely low quality. Bugatti's? Maybe similar to the younger generation "rolling ballz" on research chems and "numb hands" with UGL GH? DiscobiscuitTROPIN. I like the sound of that.

HailRazor's picture

That's a good point. I think that might be more the bio-identical vs synthetic hormone "controversy". He was commenting on 191 vs 192. Lots of talk about this on other BB forums for years. 192aa is no longer used for the medical reasons that 191aa is used for. FDA director stated 191aa was "Clinically Superior" to 192aa(Protropin) due to the lack of the additional AA and minor differences in the protein structure. I guess technically they aren't the same. Somatropin/Somatrem. Probably similar to GHB/GBL or MDA/MDMA/MDEA. These have the same name "X" or "G", but different effects. Similar, but not the same. Like most of the UGL GH I assume. Not all, but most. Maybe it's more like MDMA compared to Bath Salts. In reality, running a HRT dose of Legit GH alone isn't going to perform any miracles anyway.

HailRazor's picture

I think the confusion lies in the information from studies of (A)GHD (neutralizing/non-neutralizing  hGH antibodies) based on quality/correct biopharmaceuticals (Somatropin/Somatrem) vs a black-market product. It's been an ongoing topic for years. I'd like to learn more about the additional AA(methionine) and "structural differences" in black-market GH. There's been some recent articles (safety concerns) about prescribed rhGH for aGHD. (mouse-cell)HIV patients, pre-constituted/PEG rhGH (aGHD) being prescribed leads me to believe that "structural" and purity(endotoxins) are the concerns (antibody-bioavailability) and not the additional AA(methionine). But, any informative info is wanted....I'd like to learn more about the subject.

noob143's picture

They are not even close to the same. 191 is an identical match to natural growth. 192 is one amino chain link heavier(layman's terms). They don't respond the same. So there fore they're different.

Doss's picture

192aa does not illicit the same growth factor response as 191aa. In fact, igf is unaffected.

Doss's picture

The benefits gained from true hgh don't not stop with GH itself. The majority of them lie with growth factor response (igf), and you will not get these with the knock off clone of 192aa. It is not the same thing.

HailRazor's picture

When a director in the FDA calls (191aa) methionyl-free recombinant human growth hormone "superior" to 192aa, makes you want to read up on the subject. Not sure what the FDA would say about Protropin(192aa) compared to Chinese black-market rhGH. =)
Antigenicity / Immunogenicity / Epitope ........IGF binding protein-1. Still trying to absorb it all in. Very interesting stuff.

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