Getpumped99's picture
Getpumped99
  • 66
  • CC
17955

+ 20 Lets STOP the BRO SCIENCE

ad

Before Let me tell you about my education Im a RN
I graduated from one of the top 20 Nursing school in America. An RN education includes Anatomy and physiology, Pathophysiology which this includes we learned in well detail about the endocrine system. Im writing this to stop the misconception of HCG.

Alot of forums and bobybuilders believe that HCG creates a negative feedback to the male hypothalamic pituitary gonadal axis and this is totally FALSE
HCG mimic LH and in NO WAY SHAPE OR FORM DOES LH CREATE A NEGATIVE FEEDBACK LOOP
Only Testosterone, DHT and Estrogens(Estrodoil and Oestrodoil) have a and inhibiting affect)

As you see in this image LH does not have anything to do with negative feedback loops and estrogens have a strong affect .This is why Nolvadex and clomid work so well and help us during PCT.

And we need AI because once the body see that there enough or alot of Estrogens it creates a negative feedback loop

Therefore thats why Aromasin is a wiser choice but Arimidex can work just as good only down fall is a slight rebound of short time burst of excessive E2(estrodoil)

This study below here backs up everything im typing

http://m.eje-online.org/content/155/4/513.short

This study below explains that HCG preserves our natural test production during and after exogenus Testosterone

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1478834/?page=1

So in conclusion HCG taken with and Ai to control aromatazation and in addition with Clomid and Nolvadex will make a strong PCT to regain our endogenous Testosterone production.
Now if u inject HCG alone with no Ai yes it will create a negative feedback loop because of the aromatization NOT HCG itself!!!

But i must add that we must also think about cortisol control during pct i will make another post about cortisol control during pct ive done it during my pct and i barley shrink. I only loose water weight and maybe an 1/8 inch in bicep circumference.
Anyways until next time
Happy eating Eroiders Smile

UPDATE: Thanx for the added knowledge of Numbhere we had a big debate and I learned that HCG suppress LH instantly http://www.ncbi.nlm.nih.gov/m/pubmed/19170708/
And suppress FSH after chronic use in the study below it took 3month for FSH to be suppreesed by HCG
BOTH FSH and LH are products of GnRH
That being said HCG does not stop GnRH instantly the 1st and most important step of the negative feedback loop. So clomid amd
Nolvadex will counter act this mechanism
http://www.ncbi.nlm.nih.gov/m/pubmed/3084535/

Also the longer we use HCG the more desentistization will occur to the LH receptors affecting the results of your PCT time
Using HCG during cycle which can be 10-15week has its pro and bigger con
Pro preserves testicular function Con Desentistize the LH receptors therefore come PCT time while clomid and nolvadex produces LH the LH will have no effect to the receptors therefore affecting Testostorone production by the testicles
If HCg used during PCT its used for a short period of time 4-5 weeks causing less desensitization and Clomid and Nolvadex will be used counteracting the LH suppression HCG can cause.

So in conclusion use this info and you decide how you wana take your ride either way we are still fucking our system up just one more than the other

Getpumped99's picture

An RN education includes learning the endocrine system and endocrine disorders
We are kinda like mini doctors

numbere's picture

So does high school human physiology. You're not a mini doctor, you're a nurse.

Getpumped99's picture

Tell that to the other RN in eroids

numbere's picture

Well if they claim to be a mini doctor I will give them the same response.

You criticized me for posting the last study. However, not all the participants were given nandrolone. Yet, all had their LH suppressed from hcg.

Getpumped99's picture

I clicked on it and it requires a medscape login

numbere's picture

That's odd because I don't have a medscape account and wasn't prompted for a login.

In that case thank you for posting the study so others can read for themselves.

Black.Marines's picture

hey man nice post!

Question for ya!

Let's say I forgot to take a PCT for example after just a Test cycle...
and it's a year later.

In order to raise natural test, fsh and LH levels, would both Nolva and Clomid be recommended. Or just Clomid since you weren't just on cycle.

Thanks!

numbere's picture

First you should have blood work to confirm your levels, pre and post PCT. Without BW you're just guessing.If you haven't fully recovered then you should run a 4 week PCT of nolva and clomid.

TheFlash85's picture

thats pct is world wide standard, not just eroids, its tried and tested, they are serms.

In a promo × 1
Getpumped99's picture

FR sent PM me

Getpumped99's picture

Thank you you made LvL1 now wtf does that mean lol
Do i make more muscle gains per cycle now that iam LvL1?

Justanotherguy's picture

Now you can give and take 1 karma point. Use it wisely!

FillTheSyringe's picture

Wish i could give u some karma. This is perfect

Getpumped99's picture

Give me merchandise LOL hahaha Biggrin

MegaT883's picture

Nice thorough explanation.getpump99 +2

Getpumped99's picture

Thank you MegaT883 love the mighty mouse avatar btw

Getpumped99's picture

No problem fellow eroider just tryin to help

irongame427's picture

It will indirectly interfere with the hpta feedback loop. It will cause a raise in test which some will convert to e2 which will bind to the e2 receptors in the hypothalamus which as you pointed out is the STOP mechanism for the hpta and test production.

Getpumped99's picture

Oops my miss take u said HPTA not HTPA
Yes thats another name directly aiming at males (HP Testicular Axis)

Getpumped99's picture

HTPA are hormones like cortisol and norepinephrine, epinephrine and adrenal androgens
Bros confuse HTPA and HPGA all the time
But dont worry this post is to educate and stop all the confusement

Getpumped99's picture

In addition you are mentioning the HTPA -Hypothalamic–pituitary–adrenal axis
This includes other hormones
in AAS use we worry about the HPGA-Hypothalamic–pituitary–gonadal axis

Getpumped99's picture

Sir please re read my post thats why i said you must not take it alone
If you take it with clomid and nolvadex they cover the estrogen receptors confusing the body to belive there is bo estrogens present
And the Ai will prevent E2 accumilating

So in conclusion HCG taken with and Ai to control aromatazation and in addition with Clomid and Nolvadex will make a strong PCT to regain our endogenous Testosterone production.

MT38's picture

That's cool that you didn't sleep through class and all but back to the bro science... If you take hcg with test (preferably a prop taper ime) and then follow with a solid nolva/clomid or torem/clomid PCT, you get your shit back... Just to keep it simple for the lesser inclined in the pathophysiology of the LH and FSH function. ;)
Good post, bro. +1

Getpumped99's picture

We all love Bro Science <3

Justanotherguy's picture

This is clearly directed at me lol. Well let me be the first to say you have clearly presented a strong argument to my previous statement, and I'm man enough to admit when I'm wrong. You clearly put a lot of effort into this post. Two more questions however:

1) The HcG study is from 1991, has any more informatiok come foward pertaining to it?
2) what's your stance on desensitization of the leydig cells due to Hcg overuse?

+2

Getpumped99's picture

LoL no it wasn't you just reminded how many times I've read it in the internet.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1478834/?page=3
On this study as linked above page 75 Biological Action at cellular level 3rd paragraph talks about receptor affinity and degradation

Yes the study is old but the simple fact that LH doesnt have a negative feedback loop still pertains to current text books as hcg mimic LH this fact will stay true
If you search other hcg studies the only thing hcg does mildly supress is FSH
But as MedDx stated clomid n nolvadex will overcome that problem
Thats why it's important not to take hcg alone
These compunds work synergisticly

Justanotherguy's picture

Thanks for the studies bro. Once again, fantastic job, keep stuff like this coming!

Getpumped99's picture

Yea fosho when i have time ima talk about Testosterone:Cortisol ratio during the critical weeks of PCT

mightymouse1000's picture

Good post, nice effort.

Hustle28's picture

Hcg helps with Lh but what helps boost ur FSh ??

Hustle28's picture

Thanks!!

xflipside's picture

Gnrh too I believe, triptorelin (spell check)

Owes a Review × 1
Getpumped99's picture

Hard to find real triptorelin tho?
Even if u did the dosage needed is high

MedDx's picture

Nolva helps FSH...clomid helps LH and some FSH..

MegaT883's picture

Actually they both raise LH and FSH but Nolva is more potent. 20mg of Nolva is equivalent to 150mg of clomid in raising LH and FSH in this study

http://www.ncbi.nlm.nih.gov/pubmed/640052

http://www.ncbi.nlm.nih.gov/pubmed/6128318

Getpumped99's picture

I live by NCBI its like the bible to life

Hustle28's picture

Thank u sir =)

More by Getpumped99