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+ 4 Article on Hcg/Hmg/lhrh

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UPDATE: THE EXACT AMINO ACID SEQUENCE OF THIS SHORT ACTING FORM OF LHRH IS-pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.  
Also known as GNRH1 and luliberin. THIS IS NOT TRIPTORELIN, IT'S COMPLETELY DIFFERENT!

UPDATE ON TESTICULAR SIZE. The average male testes are between 18-25 ML or cm3 (cubic centimeters squared). You can roughly calculate this by measuring your testes legth width and height. So HxLxW=cm3. This formula is done useing centimeters so if your balls are 2 inches long thats 5 centimeters. Im puting this in hear so you guys know the average adult testicle size so you can know whats normal and obviously there are some guys who have bigger ones. This is just a referance, i think its important to measure one's testicles to see how much or if they have atrophied on cycle. People always say keeping your balls from atrophying on cycle makes recory easier so why not measure as testicular atrophy on cycle is common and usually associated with being shutdown. My testicles are within the normal range of 25ml or more and thats after being on cycle over almost two years granted with some short breaks. I believe and know i have maintained my testes by the use of hcg and other HPTA stimulateing drugs on cycle.

I found this on another forum from years ago. Im alittle obsessed with keeping the hpta intact as i like my balls and want to have some form of a functioning hpta when i come off years from now. Ive run all three coumpounds and am currently running hcg and lhrh in the form of liberion i believe is the name. Its a very short acting gnrh realeasing hormone that stimulates fsh production in short pulses or simply put injected once not multiple times throughout the day. Im using 57mcg with 500iu hcg twice a week its working great as my balls are bigger then with hcg alone and keep in mind that increase is while im on cycle. Hope u enjoy the read.

ALSO-What really caught my eye was the fsh being higher with lhrh therapy than with hcg and hmg combined. Why you ask.......... in all the studies ive read where one was trying to normalize the hpta if fsh was nil to none and lh was normal the pct or hpta normalization attempt failed. This leads me to conclude that without fsh production lh means jack shit and your hpta is fucked without fsh production. Which is why i think lhrh may be usefull in the short acting form as a possable hpta resart tool or to keep it functioning on cycle.

"Two-year comparison of testicular responses to pulsatile gonadotropin- releasing hormone and exogenous gonadotropins from the inception of therapy in men with isolated hypogonadotropic hypogonadism

L Liu, SM Banks, KM Barnes and RJ Sherins
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.

Men with the complete form of isolated hypogonadotropic hypogonadism (initial mean testes volume less than 4 mL) require 2 or more yr of exogenous gonadotropin therapy combining HCG - human chorionic gonadotropin - and human menopausal gonadotropin (hMG) to achieve maximal, but subnormal, testis size and sperm output. To test whether pulsatile GnRH therapy, which more closely mimics normal hormonal stimulation, would accelerate or further augment testicular growth, hasten the onset of sperm production, and/or increase sperm output more than occurs during conventional exogenous gonadotropin therapy, we administered either HCG - human chorionic gonadotropin - /hMG or GnRH from the inception of therapy to 2 comparable groups of men with complete IHH (initial testicular volume, less than 4 mL) and compared their testicular responses during the first 2 hr of therapy. Five men were treated with pulsatile GnRH in doses of 143-714 ng/kg every 2 h, sc, while 11 other men received HCG - human chorionic gonadotropin - (2000 IU) and hMG (75 IU FSH - follicle stimulating hormone - and 75 IU lh - leutenizing hormone - ) im 3 times/week. In the GnRH-treated men, the mean plasma total and free testosterone levels during therapy rose to within the normal range, but were significantly lower (P less than 0.01 and P less than 0.02, respectively) than those in the HCG - human chorionic gonadotropin - /hMG-treated men. The mean plasma estradiol concentrations during therapy were within the high normal range and were similar in the two groups. The mean plasma FSH - follicle stimulating hormone - levels achieved in the GnRH-treated men were significantly (P less than 0.01) and 1.3- to 3.2-fold higher than those in the HCG - human chorionic gonadotropin - /hMG-treated men. The mean testicular size achieved in the GnRH-treated men was not significantly different from that in the HCG - human chorionic gonadotropin - /hMG-treated men (P = 0.08); the mean testicular volumes after 2 yr were 4.8- and 4.3-fold the pretreatment values in the GnRH and HCG - human chorionic gonadotropin - /hMG groups, respectively. After 12 months of therapy, sperm production had occurred in one man in the GnRH group and in no subject in the HCG - human chorionic gonadotropin - /hMG group. After 24 months, two men in the GnRH group and eight men in the HCG - human chorionic gonadotropin - /hMG group produced sperm. Thus, 40% of the GnRH-treated men and 80% of the HCG - human chorionic gonadotropin - /hMG-treated men (P = NS) produced sperm after 2 yr of therapy. The sperm concentrations in all men were below 5 million/mL and were comparable in the two groups (P = NS). These results suggest that pulsatile sc GnRH therapy for the first 2 yr does not accelerate or enhance testicular growth, hasten the onset of sperm production, or increase sperm output significantly compared to HCG - human chorionic gonadotropin - /hMG. "

MAC's picture

So, in laymen's terms how would you put it?

Like what are the doses and protocol to keep the boys going?

Jman1987's picture

That's if your on cycle. HCG should be injected every 4 days because that's its half life. If you PCT with HCG as I do every time you wanna run 2500iu every 4 days for about 6-8 weeks. Run Nolva in the beginning two weeks into the Nolva and HCG add Clomid. Run the Nolva for 30 days and Clomid for 30 days as well but make sure they have that two week overlap. Run the HCG all the way through until you finish the Clomid. Then go get bloods and you should come back with some pretty nice results.

Alpac's picture

Hi Jman how are you. I am Alex and 27 years old. Im new to pct and cycling and have secondary hypogonadism. Please can you help a spongebob fan out. My lh and fsh are at 1.2 to 1.5 iu/l free test is 230 and test is 9.9 nmol/l shbg is 24.
So need to restart my hpta. I have been having severe insomnia and have neqrly died from lack of sleep. I really would love to fix my insomnia because it says hypothalamus problems cause insomnia.
I just need to know what my cycles should look like. Like week 1 etc and when to rest this drug. Then change and change drug. I am trying to follow your pct and anonymous's cycle and these are what im trying to use.

Clomid mg?
Nolva mg?
aromasin mg?
GNRH1 Luliberin (anonymous said 40-50, 57mcg?)
hcg 500iu 2 x week for cycle and 2500ui fo pct?
hmg (mg?)
Triptorelin 100mcg
d-asperic acid 1 month?
Andractim dht cream

All i need is one thing. A friend to help write up in a easy way what my weeks and months should look like.

dht cream because i have stunted growth down there. (And can i add this and when should i use it)

Do you know how i can use all of these to fix my fsh free test total test and lh. Thanks man. I pray to god for help. I have money but i need knowledge. I have a doctor but they will only inject.
If you want me to show you blood tests mate let me know. Only you and anonymous can help me because I wanted to start gnrh treatment and you are so smart.

Can you message me on [email protected]
If you can ty sir

Jman1987's picture

I understood completely I only said that so anyone else would know that you are talking about being on cycle is all. So some newbie doesn't go try to PCT like that lol

hulk420's picture

Im planning on running an 8 week cycle of test c, tren a, and, proviron. was planning on dosing hcg for the last 5 weeks at 500ui twice a week. Do you think I need it during pct as well or is nolva and a natural test booster with d aspartic acid good enough for the pct?

hulk420's picture

Ok I am planning to extend the cycle 10 ten weeks and use test p for the last 2 weeks so I have an easier time with pct. I will take your advice on the hcg and run it how you suggest. I have done some more research on it as well and that sounds like the best thing to do. Im still young and dont want to end up on TRT for trashing my testicles on cycle. Also I was gonna run clomid with the nolva as suggested by a few others to bring my natural test back up.