+ 1 Why aren’t new compounds being made?
I feel like many of the tried and try stuff is good but dated, the oral steroids are great but because they are so liver toxic not practical but because they are so potent to compensate for liver toxicity is also their strength, why don’t people remove the liver toxicity of oral steroids and make add esters to them make them all injectable? They are so much stronger than regular anabolic injectable steroids.
Right now I’m blown away by the potency of injectable superdrol. It feels like the way I used to respond to tren ace and npp / deca but instead of watery muscle I’m getting dense thick muscle which I love. It gives the illusion I have a big bone mass which I’ve always suffered with a bad bone structure low bone mass.
I wasn’t gonna post this but it the time of posting it as 11:11 so I see it as a omen to post my anecdotal experience with injectable superdrol.
I’m no chemist but I know when the oral steroids are converted to injectable form they still have the liver toxicity aspect in them in the chemical structure of the compound. Why don’t they remove that aspect and add esters to them instead?
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These guys covered the topic, but semi-related:
What were the compounds used in the BALCO case that Barry Bonds was using? The cream and the clear? If they were so effective for him why have they not been synthesized more and in the market? I guess I could Google that myself…good thing it’s Saturday.
I’m not an organic chemist or medicinal chemist, so someone with that background can absolutely correct me if I’m wrong, I’ll happily admit that I’m wrong. But I think the issue is that the liver toxicity isn’t just a separate “feature” you can remove.
The 17a-alkyl modification that lets many oral steroids survive first-pass metabolism and remain orally active is also closely tied to why they’re harder on the liver. Remove or substantially alter that, and you’ve often changed the compound itself, its potency, receptor binding, metabolism, half-life, or even whether it works as intended.
Adding an ester isn’t a universal solution either. Testosterone, nandrolone, primo, etc. esterify well because of their chemistry. Many oral AAS don’t lend themselves to the same approach, and even injectable versions of some oral compounds don’t necessarily eliminate their inherent toxicity.
Medicinal chemistry is basically a game of tradeoffs, to the best of my understanding. Thousands of anabolic derivatives have been synthesized over the last 70+ years. If someone could make a compound with the anabolic potency of Superdrol or Tren, the safety profile of testosterone, minimal liver and lipid effects, and a long-acting injectable ester, I suspect we’d already know about it.
Again, that’s my understanding, not my field of expertise.
Great write up man very accurate!
With the oral compounds we have that are so liver toxic it is the addition of the methyl or ethyl group that makes them so good and bad at the same time. Superdrol for example is just Drostanolone (Masteron) with a methyl group added to it. Not only does this make it orally bioavailable, but it totally changes how the compound interacts with the body. The same for d-bol and boldenone.
If an ester could be added you would just extend the release of the compound, not reduce the toxicity of said compound. For example TNE is to Test E like adderall is to adderall XR. It’s the same exact compound you just alter how long it will take to be metabolized by the body. By removing the toxicity aspect you would most likely remove the desired aspect as well. ( this paragraph was not directed @Bodhi)
Good topic to bring up @lifting211. I’ve always found this type of conversation very interesting.