Clearing your receptors…Or maybe not.

So, I’ve been reading a lot about people talking about “clearing your receptors” in order to produce greater effects from cycle to cycle etc. I’ve been doing a little research on this subject and I just have a very hard time believing this to be true. Is this “bro science”? I don’t know. It’s hard to find any real evidence of this because how would you test this?
What I will bring to you is truth about the mechanisms of certain actions involved which allows you to make your own judgments.

How is testosterone produced?

Simple…
1.) Hypothalmus produces GnRH
2.) GnRH stimulates the production of LH and FSH in the pituitary
3.) LH and FSH are transported to the testes
4.) Testosterone is produced.

What about heightened states of Testosterone during a cycle?

Aww the negative feedback loop…

1.) Free Testosterone (which is the T that steroid users are concerned with) sends a message to the hypothalamus and the pituitary.
2.) This inhibits the production of GnRH
3.) Inhibition of GnRH causes an inhibition of LH and FSH
4.) Thus, our natural T production is virtually shut down.

So, how does this affect our receptors?

Well this is where it gets interesting. First off, I don’t like when people talk about the receptors on the cells! Testosterone is LIPOPHILIC!! It freely passes through the phospholipid bilayer of the cell. Once inside the cell it binds to the Androgen Receptor. Once bound to the AR, it is transported to the nucleus of the cell where it is transcribed within the DNA molecule and then translated as a protein within the muscle cell. This is its anabolic properties.

Now, where the confusion to me is; what evidence do we have that these Androgen Receptors all of the sudden become saturated and don’t do their job anymore? That would then become a whole new issue. If anyone has ever done any research on the effects of decreased androgen receptor sensitivity, you would understand the serious effects of this.
Decreased androgen receptor sensitivity is only caused by genetic mutation of the gene or other kinds of mutations within that process. This is NOT what steroids do. All they do is USE the AR as a pathway to the nucleus of the cell. This is where my skepticism occurred in this whole “clearing receptor theory”. If we were in fact destroying the use of our receptors; I would seriously consider stopping the use of steroids all together. However, I don’t think this is what we are doing at all.

Androgen Receptor Agonists…
1.) Testosterone
2.) DHT

Androgen Receptor Antagonists…
1.) Bicalutamide
2.) Flutamide
3.) Nilutamide
All of these are drugs made by pharmaceutical companies and not produced in our body

But why do I have to take more compounds to get bigger?

Well let’s say you’re 180 lbs and your first cycle of Test C for 12 weeks got you to 200 lbs. You cycled properly and took proper time off and eventually here you are at 190 lbs. If you take the same exact cycle for the same amount of time, why would your body go past 200 lbs. You did NOTHING to go farther then you took it the first place. It really comes down to strict dieting and training. Some people train harder than others and get better results. It’s just a fact. Others, if you want to get bigger, faster, stronger, you have to take your body to the extreme. Why not take more compounds in order to get better results?

Listen, let me say that I do not know for a fact about the clearing receptor theory, but all I can do is raise the question. It is ultimately up to you to decide for yourself.
But I am curious of one concept of this theory. Where do we have any evidence that increasing Metabolic Rate/Activity will release the Androgen Receptor affinity specifically and ready it for binding again? And I say Androgen Receptor specifically! Not other ligands/hormone regulations.

Looking forward to feedback. Thanks.