+ 7 GH's effects, and what is the optimal length of usage
I've been asked many times by customers how really GH effects the body ? Many also are interested to know for how long it's effective to use GH ? if one has a limited budget is good to use for several weeks ?
The GH-IGF1 is possible the most complex hormonal axis in the human body. I'll try to offer some science based yet simple answers in a nutshell.
GH has a direct and immediate metabolic effects - it releases glucose and fatty acids to the circulation, meaning it takes stored energy and make it available for the different organs and tissues, this is how it increases metabolism and burns fat both directly (taking fat stored fat and turning it to free fatty acids) and indirectly by expending calories and energy consumption. Note that releasing glucose to the circulation requires the body to secrete insulin immediately in order to balance the glucose levels and lower them back to normal, this mechanism leads with time to decreased insulin sensitivity, as when taking superpharmacological levels of GH the body needs to secrete constantly relatively high amounts of insulin. So GH increases insulin levels and decreases insulin sensitivity (which may bring to insulin resistance in extreme cases - diabetes)
GH has a direct and immediate anabolic effect in the body - it causes different tissues (above all muscle) to retain nitrogen which leads to a positive nitrogen balance = anabolism. It also causes the body to retain minerals (sodium, potassium, calcium, phosphorus) as part of its anabolic effect as well, which explains the quite noticeable and fast water retention many users experience with GH.
Having said and explained that many of the muscle building properties of GH are mediates by IGF1 which is considered the most anabolic hormone in the body. Even if we block somehow the IGF1 secretion which is induced by GH it'll still retain some of its anabolic and metabolic effects directly through GH receptors in different tissues, but big portion of the effect will be abolished, this is why in rare condition when short statue children don't respond well to GH treatment they're treated with IGF1 (prescribed Increlex- you my refer for some info for instance to https://www.eroids.com/forum/hgh-peptides/rhgh/somedin-igf1-lr3-vs-incre...). The GH causes IGF1 secretion from target organs such as the liver and kidneys, and the IGF1 travels in the serum to different tissues (endocrine effect). The GH also causes a local section of IGF1 (and other growth factors) on different tissues, mainly on muscle tissue, it's called autocrine effect, and it's responsible on the stimulation of cell division, and this explains some of the unique so desired effect of GH (and IGF1).
While the direct anabolic effects of GH are quite immediate (though not as prominent as the effects of anabolic steroids), the autocrine effect takes time and requires constant exposure to effective dosages.
GH has another important effect - it directly triggers fibroblast activity, which means recuperation and creation of connective tissue, this of course enables optimal recuperation from injury, this trait enables better strength=muscle gains with time. Like the phenomena of new muscle fiber creation it the fibroblasts activity takes longer time to become pronounced, connective tissue is the slowest to be built and/or recuperate.
The GH is used in the medical field as a short term anabolic aid for post trauma/surgery/severe-burns so yes short term of a couple of month certainly has its benefits, and will create some new muscle fibers to some extent, but as athletes knows GH really shines in a long term usage
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HGH usually takes 4-5 weeks to kick in for muscle again and fat loss on cycle. This assumes more than 2IU/day Pharma grade. Anything less is a waste. Generics very so greatly in quality its a guessing game. Most common sides are carpel tunnel and joint swelling.
Another important subject in regards to GH usage is which protocol to follow.
I would generally advocate to bi-daily injections pre-meals, this is the proven pharmaceutical approach with Dwarfism.
However many find the protocol of injection IM EOD as a better solution (example for this - https://www.eroids.com/pics/igf-score-from-14ius-somastim). One of the main advantages here is lowered side effects, and better durability of the body.
Bottom line the optimal protocol is a matter of trial and error, and I would love to hear from your experience on this subject
Once get above 6iu I am thinking of giving the EOD bi-daily pins a try or do you think I need to be above 6iu for that protocol to be worthwhile. Usually I just pin my dose (around 4iu) preworkout ED.
I basically and generally believe the higher the dosage the more justification there should be to split it, but it certainly worth a trial and error. There many parameters here to consider as well, for instance your daily schedule and other products you may be using
I've been asked by customers on a daily basis on the comparison between GH and IGF1, here is an older link which is quite relevant to this one and may shed some light on this subject- https://www.eroids.com/forum/hgh-peptides/rhgh/gh-igf1-and-should-i-comb...
Which sides has HGH, beyond Acromegaly?
I mean, has it any impact on the natural GH secretion or on HTPA?
Acromegaly is not a concern to the average user, this phenomena requires superphysiological levels of 5-50 times the normal levels along years
When you inject exogenous GH it shuts down the natural GH production (both directly and indirectly by somatostatin secretion)
Thank's for reply.
So if someone wants to keep back on natural GH after long period of exogenus, is there any PCT for "stimulating" Endogenous GH as it happens for steroid cycles?
The answer is generally yes, and there are some practices how to do it with peptides, if you asked me there are all doomed to failure as any exogenous with unnaturally elevate GH levels will cause the same negative impact on the baody's natural HGHRH (Growth hormone releasing hormone) secretion from tye HPTA. I would let the body do itself and encourage natural GH release with GABA, Alpha-GPC and Dopamine precausers
GlycogenGuyKarl at what level would you see the growth of your head or jaw? My head is already big lol
Lol, u don't have enough budget to reach acromegaly brother, no worries, it takes years of relatively high dosage, u may see it on some pros
GlycogenGuyAwesome! I will be in touch soon Karl
I plan on getting an igf test from 9iu serostim.
When should I do this (how many months)
Anyone who is interested in making some blood test may contact me, will add gifts for such
Nice read Karl. I typically run GH (along with IGF now) only around my cycles. I like to start a month or so before cycle so when cycle hits I am at my highest IU dose. Don't want to be ramping up dose and miss out on gains while in high anabolic state from cycle. Then I run for a few weeks after cycle until hormones are stabilized and thats it. Seems to working out pretty well that way.
Yes I agree - have seen this scheme working well, and it mets logically the science behind these products
basskiller89Great read brother
I'm starting a HGH run in a few months
4-6ius 6 months to a year, what a transformation. Assuming diet and training are on point of corse.
Good info! Thanks. Thougts on hgh's effect on
thyroid function?
Use t4
Recommend dosage of t4? If using 6iu of hgh
Go with bloodwork. I’ve never seen my T4 or any thyroid hormones impacted my GH. I know it happens but I believe it’s very individually specific.
Dr. Rand:
https://m.youtube.com/watch?v=uESDM-qSssg
Cheers brother. Good watch!
basskiller89A diet with medium to higher amounts of sodium should also provide enough iodine to keep up with a higher demand for T4 as a possible natural alternative, please correct me if I'm wrong
saffirei did have higher amounts of sodium with enough iodine but it didn't help i still would use t4, ( used 4iu/Day)
basskiller89HGH would speed up the conversion process but limit metabolic effects from T4 to intake. I could see the desire the add in T4 if sodium isn't working. What dose did you do for T4?
Great info!