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  • karlsx's picture
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  • Somedin (IGF1-lr3) vs Increlex (prescribed IGF1)

  • karlsx   •   Sun, Sep 4th, '16 10:09   •   9 replies, 1789 views

I would like to share some scientific info on the common and differences on the Somedin IGF1-lr3 which is widely marketed for athletes, and Increlex which is a IGF1 product prescribed to children who suffer from a condition called severe primary IGF-1 deficiency.
Increlex contains IGF1 that is identical to the human endogenous IGF1 , while the IGF1-lr3 is a configuration of the IGF1 molecule. The LR3 stands for an addition of a "tail" added in a certain formation to the IGF1 molecule, this makes the IGF1-lr3 much more potent.
For a brief explanation (refer to http://www.ncbi.nlm.nih.gov/pubmed/18567600) - The actions of IGF-1 in vivo are modulated by IGF-1 binding proteins (IGFBPs), which generally act to inhibit IGF-I signalling. the analogue of IGF-I (LR IGF-I) has a significantly reduced binding affinity for IGFBPs. In simple words most of the IGF1 in the body is bounded to binding proteins (same as u probably know is testosterone and other hormones) which makes it non active, The new configuration in the Somedin helps it travel in its active form in the serum and activates its receptors much much more effectively. As you may check in a simple google search on the Incralex it requires much higher dosages - a kid may require 12000mcg a day (like 150 times higher dosage then a 240lbs athlete may need)
Now anyone may ask himself - why then the prescribed IGF1 is not IGF1-lr3 then ? - I'm not an expert for this subject but I may speculate, a very based speculation, that making a drug to a prescribed drug simply requires the investment of great deal of resources and tedious 3 phases of clinical trials, while there are very few kids who are prescribed with IGF1 (the only ones to get this med are the ones who has a mutation in their GH receptor (rare) so GH conventional treatment doesn't work on them)

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  • karlsx's picture
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  • karlsx
  • 7 months ago

I've been asked many times by customers/members on the differences between Increlex (pharma marketed IGF1) and the Somedin (IGF1-lr3), and I find this thread to be an appropriate read so so would like to make few points here clearer

The issue with IGF1-lr3 is that there are no clinical trials in humans, having said that there are clear evidence for its superiority to IGF1 on mammals studies such as the one below. The IGF1 role and effect (both systemic and locally) is quite identical in all mammals so it'll e safe to conclude from these studies on the clear advantage of the IGF1-lr3 on the Increlex, not to mention that it's much much more price competitive as requires like 100 folds lower dosage

https://www.ncbi.nlm.nih.gov/pubmed/18567600 -

  • You may learn that the IGF-lr3 higher effect stems from much lower affinity to the IGFBP which enables much longer half life and much superior ability to interact with the IGF1 (and insulin) receptors

  • There is in vivo clear evidence for a superior effect of the IGF1-lr3 on regular IGF1 treatment - "In contrast to the mechanism of protection conferred by administration of IGF-I, the protection conferred by LR IGF-I was independent of changes in muscle fatigue and oxidative metabolism. This study further indicates that modulation of IGF-I signalling has therapeutic potential for muscular diseases."

  • peggy7's picture
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  • peggy7
  • 1 year ago

According to Jh.. Mead..s, he says that the pros only get their increlex by some guy in France. They call him Mr. Increlex!.. Anyways, I just ordered 2 hgh and 2 IGF-1 LR3 from Karl. I'm actually a college student and I have access to labs to test this products.. I could give a feed back later on. I'm sure Karl has some good products

  • AlexPatriot's picture
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  • AlexPatriot
  • 1 year ago

Thx for the info m8.

  • karlsx's picture
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Sure bro, if need any assistance you may alway PM me

  • GravesTop's picture
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  • GravesTop
  • 2 years ago

Good info...tnx

  • Theonslaught's picture
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  • Theonslaught
  • 2 years ago

So who has left igf LR3 lol

  • Zanda's picture
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  • Zanda
  • 2 years ago

Thx for the info. Always looking to learn more....

  • irongame427's picture
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  • irongame427
  • 2 years ago

Your right about why they arent developing LR3 for human use, not enough kids. Increlex failed, ipsen is hardly producing it anymore. Gh is the standard of treatment for gh/igf-1 deficiency but some kids livers won't produce enough igf-1 no matter what dose of gh is given so they developed increlex to bypass the liver all together. But still increlex was a bust. So there not gonna make rx LR3.

  • angie's picture
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This is my problem!
10-15iu of hgh (from hospital) my body is changing but my igf-1levels is almost the same that my endogen level.
I have no problems with liver, I dont take antitrogens etc...
What happen with my igf-1 level??