Let me start out by saying I have been on TRT for around 5 years. I have been cycling or "blasting" for around two. I have been forced to take anti-estrogens constantly throughout the last five years and have had extensive blood work done on what I would say are the three major anti-estrogen's. Although this may not help everyone I hope to help a few beginners but who knows, everyones body is different.

My doctor is pretty flexible and lets me guinea pig a lot of things. I have probably helped him out and taught him a lot bases of my results and labs but hey not everyone wants to donate their body to science.

Three major anti-e's according to my doctor and Arimidex, Aromasin, and Letrozole. He has prescribed me each of them so all of my experience is using pharma grade or pharma compounded anti-e's.

I have ran through each of these about 2 different occasions. I'll review my experiences and knowledge with each.

ARIMIDEX - is my favorite and most used. It is very easy to dose control for me AS LONG as my test dosage per week did not exceed 1g. I have found that when I went above 1g test p/w my estro was essentially uncontrol-able with arimidex. I have taken up to 2mg, which is a huge dose on a couple of occasions and and my estrogen still came back above normal levels. Also, If using pharma grade Arimidex, the name brand is WAY more powerful and effective than the generic. I know this is the case with a lot of medicines but i could literally half the dose and the labs were similar. This also had the quickest "kick in" time in my experience. Longest half life, dosing was only need eod or e3d. On trt doses you could probably even get away with 2/weekly.

Letrozole - Incredibly hard to dose control and in my experience DID NOT kill all estrogen as many may think. It was more powerful than both of the others but in no way inhibited estrogen completely at doses up to 1mg. My doctor claimed that in his studies it was only 20% more effective at reducing estrogen in males than the other two options. In females, it obliterates estrogen. I would not suggest this to new or inexperienced users.

Aromasin - Harder to dose control than arimidex. E2 seemed to jump around quite a bit more in my tests. Also was more effective when running higher doses, 1g+. The kick-in time also seemed to be longer as I didn't experience the same quick "dry" feeling that arimidex produced. More or less similar to adex.

I would suggest arimidex to all new users as it is easiest to control and normally cheapest to buy.
Anti-e's are ABSOLUTELY necessary in every cycle. Some may not be so prone to gyno but it isn't worth the risk.

I realize this post may not apply to all as their are quite a few aromasin fans out there. Rep what works for you!