AOD 9604: Advanced Obesity Drug (modified Peptide Fragment of HGH) Molecular Formula : CC78H123N23O23S2 Molecular Weight: 1815.1 CAS No.:N/A Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

AOD 9604 is a modified form of amino acids 176-191 of the GH polypeptide.

This peptide Is supposed to be able to increase your ability to burn fat,in particular abdominal fat.There are also some suggestion of increased energy and stamina.

I have NO personal experience with this peptide.I have 1 associate that has used it,outside that I personally don't know anyone else that has used it.I am looking for people that have used it to share their experience.My associate did report increased fat loss and energy.

There are conflicting reports as to the effectiveness of this peptide and if it is even effective at all.It is very similar to hgh fragment.1 of the difference being that it has no anabolic effect.No effect on IGF1.

The only thing 1 feel 100% confident in is that this peptide presents NO consequential negative health implications.The worst scenario is that I waste my money giving it a try.

There were 2 uncommon but notable side effects. Head ache and slight euphoria

My research has had a difficult time coming up with a dosage amount.I have decided to start with 250mcg twice daily .Once preworkout and once right before bed for a course of at least 2 months.

Here are a couple brief studies and explanation I found helpful to site:

Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity following long-term treatment in mice. One mechanism by which this may occur is through an interaction with the beta-adrenergic pathway, particularly with the beta(3)-adrenergic receptors (beta(3)-AR). Here we describe how hGH and AOD9604 can reduce body weight and body fat in obese mice following 14 d of chronic ip administration. These results correlate with increases in the level of expression of beta(3)-AR RNA, the major lipolytic receptor found in fat cells. Importantly, both hGH and AOD9604 are capable of increasing the repressed levels of beta(3)-AR RNA in obese mice to levels comparable with those in lean mice. The importance of beta(3)-AR was verified when long-term treatment with hGH and AOD9604 in beta(3)-AR knock-out mice failed to produce the change in body weight and increase in lipolysis that was observed in wild-type control mice. However, in an acute experiment, AOD9604 was capable of increasing energy expenditure and fat oxidation in the beta(3)-AR knock-out mice. In conclusion, this study demonstrates that the lipolytic actions of both hGH and AOD9604 are not mediated directly through the beta(3)-AR although both compounds increase beta(3)-AR expression, which may subsequently contribute to enhanced lipolytic sensitivity.
PMID:

11713213

[PubMed - indexed for MEDLINE]

Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, AOD 9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals and humans. Recent findings have shown, in addition to its fat loss properties, AOD 9604 processes many other regenerative properties associated with growth hormone. Currently trials are underway to show the application of AOD 9604 in osteoarthritis, hypercholesterolemia, bone and cartilage repair. AOD 9604 has an excellent safety profile, recently obtaining Human GRAS status in the USA

The difference between AOD9604 and HGH fragment 176-191 is not the sequence but the status of the sulfhydryl group in cysteine.

The sulfhydryl group in AOD9604 is oxidized form disulfide bridge (MW: 1815 CAS:221231-10-3)
AOD 9604.jpg
The sulfhydryl group in HGH fragment 176-191 is reduced form(MW:1817 CAS: 855516-60-8)

HGH FRAGMENT.png

In Organic chemistry Lab, you need 1 or 2 more steps to synthesize AOD 9604 from HGH fragment 176-191:
synthesis of AOD9604.png

All the structures data is from reaxys.com or science finder, please refer to them for their contribution.

ONCE AGAIN GENLEMEN,I AM HOPING SOME ONE CAN SHARE THERE PERSONAL EXPERIENCE OR RESEARCH.?????????

I will be conducting my own experiments beginning this week.I will report my progress. Thank You