+ 7 aromasin dosing (study in males)
a study of aromasin dosing and findings in young males. the study was published in the Journal of clinical endocrinology & metabolism.
I am going to attempt to give a general synopsis of this study.
the study was conducted on healthy males 14-26 yrs of age, they were given between 25 and 50mg exmestane. blood was drawn 24 hours before and after dose. estrogen plasma suppression was comparable between both doses 25mg @ 38% and 50mg @ 32% with a variable of less than 1% it did not effect lipids or IGF-1 levels although there was an increase in testosterone concentration levels by approximately 60%.
During the study it was noted that there was rapid absorption which led to the finding that in males the terminal half life of 8.9 hours, terminal half life is the time in which plasma levels are devided in half and also determine the time at which the compound accumulates and it is stable in the blood. so 8,9 hours is a very short terminal half life by comparison. maximum suppression based on dosing regimine was at 12 hours with a variable of 14% in rate of suppresion.
exmestane is an irreversible aromatase inhibitor often refered to as a suicide inhibitor. when exmestane is absorbed it become an intermediate (broken down) and binds to the estrogen (enzyme) and inactivates it.
so the basis of this study does several things.
The study demonstrates the suppression level to be between 32% and 38%.
an ideal dose of emestane based on this study is between 25mg and 50mg (i think its a little high for most AAS users) and also shows that the actual half life is very short (8.9hrs) and maximum time of effectiveness.
those using AAS may want to dose more frequently (every 12hrs) to maintain stable blood serum levels of exmestane. those who also have felt the exmestane was not effective for them may reconsider based on these findings as they may have been dosing incorrectly.
source link
http://jcem.endojournals.org/content/88/12/5951.full
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How many Aromasin users have switched up to taking it 2 times a day because of the short half life. Do you think that the daily spikes and dips in estro levels for people dosing just once a day would be a problem?
I'm working on finding my sweet spot of Aromasin, and so far it looks like 5mg ED is it.
I just started taking proviron n upped my test by 100mg a week and been having issues with gyno/high estrogen I'm taking .50mg arimidex a day and 12.5mg am/pm (25mg a day) aromasin and after 2 days I'm finally not puffy and emotional. I'm pretty sure the proviron is what is causing the estrogen spike with the additional free test since I'm a super high aromatizer. Initially I was taking 25mg aro and the 1/2mg adex in the AM but by bed time I was puffy again. Now with the aro split its not.it Could also just be that its had time to build some blood serum levels and clear me out some either way ill continue till I start feeling some low E sides than back off dose amounts
Well I'm still confused I can't tell if I'm sweet spot up or not lol cause I feel tired at times then dose off n daytime could that be just fatigue cause I can't tell but chest feels a little puffy
i cant speak for everyone here, but i often see and also experience this issue with aromasin. i often see others who deal with low estrogen issues with aromasin before the gyno symptoms are under control. this is why i combine more than AI when i start having aromatization issues. my goal is to kill the free estrogen in my blood and tissue but also control or negate the gyno and future rebound. so i dont go out of my way to control estrogen simply with aromasin because if i did my body would be hurting and id be exhausted and still dealing with gyno, so i add the adex which controls the gyno and the aromasin controls any further conversion.
DISCLAIMER:
this is what i do because i am a super converter i dont recommend anyone try this. i am aware of my body and how to address these issues for myself only. the information is for educational and informative purposes.
trying this with out awareness could result in serious estrogen crash and can be extremely physically and emotionally taxing, with low estrogen you are more susceptible to gym injuries because the body is unable to maintain water properly therefore cant keep muscles hydrated or joints and ligaments lubricated and with out proper estrogen levels, muscle and size gains are and can be seriously impeded.
Yo my fucking knee is like sharp pain is that like a side effect elbow to pain also plus back tight muscles cause also read as a sign if I get some fish oil would that help
yes it can be a result of low estrogen, when mine is low the first thing i notice is sore wrists. than my mood gets miserable, than after that my knees get tight, creeky and sore, can hurt to go up and down steps, also my lower back (lumbar region) and between my shoulder blades gets stiff, tight and lower back cramps easily, and my elbows will get sore. i will get headaches very easily too. my blood pressure is high and im dehydrated.
Can fish oil help or do I need to go cold turkey on aromasin again cause I can't get the hang of this should also go get some electrolytes drink lol shit killing me bro HELP lol
Thank you for more information again but still kinda confused I guess I have still play around with it
To see cause oh shit
Sic, what dose of aromasin are you taking? How long until you get your mid cycle blood work done?
+1 thank u for posting this cause I was researcing myself about aromasin an kept getting different half life's different times to take it I guess it based on person to person
nice +1
Bump.
Good write up!
Thanks for sharing. I agree that 50mg of aromasin or anything close to that would crash my estro so hard I'd probably be in bed for a week. When it comes to AIs, I say forget what the studies say in terms of recommended dose and certainly don't follow someone else's protocol. Find your own sweet spot by trial and error and of course blood work and stick to that. More is not better when it comes to AIs.
Where I think this study can help is in the timing of the dosing. Meaning once you know the dose that works for you, you can administer it more frequently.
Thanks again for sharing.
yes, that is exactly where i was going with this post. it really can be a game changer in how exmestane is approached especially for those who believe they are non responders to it. dosing protocl is something to definitely rethink now.
maybe we can getthis as a sticky in the PCT section ????
Thanks brother. I was just talking about this the other day but didn't have time to find the study. This is a real game changer compared to how we've been approaching aromasin use. +1