Clomid, Danazol and Arimidex Tri-therapy as TRT/SHBG treatment
Doc has suggested (in lieu of traditional TRT, reasons below) Clomid at 50 mg EOD, Danazol at 100 mg ED (troche not pills) and adex at 0.25 mg 2 x / week max or as needed based on subjective analysis and labs.
By way of background total test levels are "ok" - low of 400 high of 800 at intermittent testing over 5 years. Most recently 565 with E at 29. However SHBG high at 78, making free test about 6 (and thus associated symptoms).
Issue is that while TRT in the past was doable, want to have kids making that problematic.
Thoughts on this for the short, medium and long term?
Concerns include long term HPTA suppression via the Danazol, hepatic issues there too (though doc pronounces that being the rationale for the troche vs traditional oral), long-term Clomid therapy (and its reduction in efficacy over time) and transition back to TRT (whether continuing under the care of doc or self-directed with clinical intervals).
The goal is here to manage the high SHBG symptoms which are numerous, stay fertile and able to continue T therapy in the future.
- Bookmark
- 0
- 0
Good luck man, I hope you can get it all figured out. I wish I could take some of your SHBG off your hands. Looks like we have the exact opposite problems, yours is too high and mine is too low... and neither of our endos or pcps can figure out what causes it.
I cycled in a former life and my endo thinks it may be related. Combined with my years of Keto and IF, I don't doubt it. I have basically done everything I can (unwittingly) to raise SHBG. So if you want more...
Id be inclined to first figure out why shbg is high, rather than treat it. Not only is it an essential hormone, it is a predictor of other things like cancers.
Try tongkat ali for free test improvements, rather than medicating. Should be noticeable fast enough if it is going to help (which it can).
Tongkat ali is new to me. Will research. Thanks!
My other health indicators are pretty spot on so we don't have any suspicion of underlying disease (i.e. liver). I was keto and IF for years and I am only now learning (shame on me) that those are SHBG triggers - and the copious amounts of almonds I ate, lol.
These are personal decisions only you can make. You seem to be well informed on the variables, positives and negatives; so do what you feel is right for you!