posted Sun, 03/17/2013 - 07:01
2289
trying to use Thyroid 3
ad
trying to use T3. Im currently on cycle Test prop/tren a/masteron. I was wondering if using T3 for two weeks @ 25mcg ED is a good idea. The point is I'm trying to supplement it due to the tren and lose some fat. my diet and workouts are on point , its just time factor. i have not use it yet, thats why im asking 
- Bookmark
- 0
- 0
Trenbolone decreases like other steroids the SHBG values. But it also lowers the TBG which bind the thyroid Hormone. It is the same here as with the sexual hormones, only the free, unbound thyroid hormones are active. If you look at the study from 1981 trenbolone supressed the total thyroid hormones around 40%. That leads careful People to supplementing t3.
Why is that not correct?
If you look at These studies you'll see that the total Plasma values of the thyroid Hormone were measured and not the values of the free unbound thyroid hormones. Trenbolone decreases the TBG which increases the amount of free thyroid Hormone concentration in the blood stream and there is more instead of less of the free thyroid Hormone available. Even if the total Plasma values are lowered.
The Body recognizes the higher free thyroid Hormone and regulates it by decreasing the TRH and TSH releasing and with that the t4 and indirectly the t3. This effect will lead to a plateu despite the low TBG value.
Sorry for bad english :)))
AnonThat is really interesting stuff right there. Do u have any links or reference studies that confirm that? I'd really love to read some more on this brother. I've always known about the first part of what u wrote but the second part I have not. It makes sense as Tren burns so much water and fat off.
Sure
Donaldson IA, Hart IC, Heitzman RJ.
Growth hormone, insulin, prolactin and total thyroxine in the plasma of sheep implanted with the anabolic steroid trenbolone acetate alone or with oestradiol.
Res Vet Sci. 1981 Jan;30(1):7-13.
http://www.ncbi.nlm.nih.gov/pubmed/7017853
Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH.
Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor.
APMIS. 2000 Dec;108(12):838-46.
http://www.ncbi.nlm.nih.gov/pubmed/11252818
These are the most relevant
plus one!
thank u +2
AnonOnly use it after bloods show supplementation is required. Tren is known to suppress thyroid levels. Honestly you'd have to be on a lot of tren to get to that point.
Have u gotten bloods done?
no blood works will be done in a week
I personally think it would be a very bad choice do to the fact alone of the anxiety factor that can easily accompany T3 usage
u think at low doses it would have that effect?
I have no idea Beast, I know with me tren & masteron build up my aggression which can easily enough convert to anxiety. Putting the T3 into I am not sure. Also if you have any other meds in your system with contradictions that could come into play. You were wise enough to shut down your cycle when it was to much I am sure you will notice where you are at regardless of whether you use it or not. For me though I always like to have my mental clarity nice and stable and would sacrifice any substance that hinders that.
well i am controlling this cycle alot better, lowered the doses and sides are nil
Very good to hear! I no that T3 for many it had the sides of increased anxiety but I don't know the doses they were running.
If you need dosage patterns i can help
I appreciate that brother. I don't run T3 myself but I think that information would be very valuable for all here that do. Also if you have any insight into the sides per dosage scale, that would be great!
The pharmaceutical manufactured name for the thyroid hormone trijodthyronine (T3) is liothyronine. The thyroid Hormone is not directly produced from the thyorid. The thyroid produces only levothyroxin (T4) which can not get directly effective in the Body. It must first be enzymatically converted to T3. T3 regulates the oxidative metabollism. The oxidative metabolism can be defined as the burning of nurtients for the purpose of energy extraction. This metabolisation happens in the mitochondria ("the powerhouse of the cells") whereby ATP is built. ATP acts as a chemical girder for the produced energy and is the muscles primary energy supplier for their contraction. T3 is the clearly more effective thyroid Hormone of the thyroid hormones. It is four times superior to the Thyroxin (T4). Athletes use the liothyronine usually in the last 4-8 weeks before competition to show the lowest bodyfatpercantage possible.
It increases the metabolic rate by boosting the metabolizing of carbs, protein and fat faster and build more ATP. So the athlete benefits from evident increased fat burning. The higher energy consumption is partially based on enhanced cardiovascular effort which means that the heart beats faster and stronger. Alone through this effect a third of the ATP is depleted. A further effect of a raised thyroid Hormone Level is based on the enhanced production of so-called decoupleing protein in the mitochondria. These proteins decouple the ATP synthesis from the breathing and causes the energy production in the mitochondria to be more inefficent. Inefficient means in this case that more energy is released in the form of heat and is "lost" because it is not used to produce more ATP. That causes that, even while sitting around idle, a distinct higher amount of calories is burnt. Another interesting Point is that the intake of T3 raises the production of HGH. Since somatropin also induces fat burning this effetc could be another way of T3 to enhance fatburning.
According to the strength of the liothyronine it is important to be very careful with this compound. If the user does not provide enough muscle protection with highly androgene steroids or the HGH muscle loss is predetermined.Many athletes use t3 together with Clenbuterol as muscle protection which is not useful because Clenbuterol does not have anticatabolic effects in the human body in the usual dosage (if you want to know why i can text you). But it has another fat burning effect. Studies have shown that T3 increases the amount of beta-2-receptors by what the effectiveness of clenbuterol and other beta-receptor-antagonists like ephedrine is enhanced.
Suitable Steroids for this purpose would be: Stanozolol, Trenbolone, Testosterone Propionat. These compunds are highly muscle protective and complement each other.
The intake amount and the lenght of the cycle should not be exaggerated in any case. Against the widespread opinion in fact there is no threat of permanent damage or hypothyroidism but the cardiovascular burden and the interaction in combination with other substances like Clenbuterol or ephedrin must not be ignored.
For a long time it was common for Bodybuilder to use 25-50mcg t3 daily to be able to eat a higher amount of calories. Thereby a faster muscle growth is reported. The idea behind this practice is that the thyroid hormone speed up and improve the metabolizing of protein [..]. So t3 appeal slightly anabolic. But considering to the before mentioned side effects this is not adviseable.
Another group of people who use t3 are bodybuilder who take HGH. In this case the daily dose is 25-50mcg to provide the higher t3 needs while on a hgh cycle. This is not recommendable because T3 has shown to reduce the nitrogen storage caused by somatropin.
As you can surely see now, liothyronine is nothing for a beginner. Beginner should always take safer medicaments as ephedrine (ECA-Stack)...
Dosage and intake:
Usually Bodybuilder start with one 25mcg tablet in the morning and increase the dose by another 25 mcg tablet every 3-4 days until the maximum dosage (100-150mcg) is reached.
Due to the halflife of 19 hours one single intake in the morning is possible but it is more adviseable to split in 2 or three doses for a better compatibility of the stomach and a more constant drug Level. It si important not to eat or drink things which are high in calcium 2 hours before and after the intake because calcium binds thyroidhormones in the alimentary canal and inactivates them.
if you want to take T3 to cover your higher Needs while on HGH you usually take 10-25mcg a day which is enough.
To discontinue t3 it's the same as above. you decrease the dosage every 3-4 days by 25 mcg, at the and you can take a half tablet before you are at zero. This will be enough time for the thyroid to reuptake its production. Some experts recommend not to discontinue and just stop the intake after the desired result is reached becaus the thyroid will reuptake it's production shortly, even after a longer-range intake. Although this is fact is true, it is advisable to discontinue after the pattern above because it allows a fluent Transition.
Sideeffects:
Disturbance, tension, sweating, insomnia, weightloss (...), diarrhea, cardio-vascular Problems, cardiac insufficiency, Exhaustion, bone loss, myasthenia, Libido loss, erectyl disfunction, gyno.
Females additional: oligoarthritis, amenorrhoe.
The permanent damage or hypothyoridism can be counted as another Bodybuilding legend. A healthy thyroid will reuptake it's normal production even after intake for years.
Sorry for bad english
if you couldn't understand something just tell me and i'll try to rewrite it better.
Sources:
G. Löffler and P. E. Petrides, Biochemie und Pathobiochemie, Berlin: Springer, 2006.
http://onlinelibrary.wiley.com/doi/10.1002/food.19810250432/abstract
T3 negates hgh anabolism
1: J Hepatol. 1996 Mar;24(3):313-9. Related Articles, Links
Effects of long-term growth hormone (GH) and triiodothyronine (T3) administration on functional hepatic nitrogen clearance in normal man.
Wolthers T, Grofte T, Moller N, Vilstrup H, Jorgensen JO.
Department of Medicine M (Endocrinology and Diabetes), Aarhus University Hospital, Denmark
http://www.ncbi.nlm.nih.gov/pubmed/8778198
"triijodthyronin" by chemiDplus
http://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=DBMaint...
Hypothyreose: Substitution mit T4 und T3, german medicinal journal
http://www.aerzteblatt.de/archiv/17270
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPAR{alpha} dependent manner.Andrew C Adams, Inna Astapova, Ffolliott M Fisher, Michael K Badman, Katherine E Kurgansky, Jeffrey S Flier, Anthony N Hollenberg, Eleftheria Maratos-Flier
http://www.sigmaaldrich.com/catalog/papers/20236931
datasheet 3,3′,5-Triiodo-L-thyronine Sigma-aldrich
http://www.sigmaaldrich.com/catalog/product/sigma/t2877?lang=de®ion=AT
BMS Anabole Steroide - Das Schwarze Buch 2010
http://www.amazon.de/Anabolde-Steroide-Neue-schwarz-Neuauflage/dp/B0018P...
i thought you dropped your cycle?
been back on it for a week now