Molinin302's picture
Molinin302
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+ 1 Thoughts and advice

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This is where I fall short and regret not getting my master's, but the advice here is unparalleled. Ok, I'm getting ready for my next run, it's going to be the same compounds. Test and deca, I do add Dianabol in the beginning, it works for me, don't judge. My question for the more experienced members is about receptor uptake. Diabetes treatment can remain the same for many years, without increase in dosage. TRT dosage (which I'm on) seems to be the same. Where I'm going with this, is higher dosages weekly the best route or more frequent injections? Receptors can and will be flooded, and there's long and short esters... But going back to other medications, CENSORED as I mentioned, it seems to not change. Advice? I'm not convinced on the higher dosage long esters vs shorter ester more frequently. Everyone is different but there has to be a common area.

Ozninjaguy's picture

"Receptors being flooded" is a myth. Receptors are continually being renewed.

EagerToLearn's picture

Your receptors don´t really care whether there is a long fatty acid esterified onto their signalling molecule (i.e. androgens) or not. The only difference is that short esters diffuse much more quickly into the cell and lead to faster binding compared to long esters (e.g. maximum binding after a few hours vs. a few days for cyptionate. Esterification is done to extend plasma half life, but once it is bound to the AR (after it either diffused into the cell or is shutled into it via a transporter -science doesn´t really know yet) it doesn´t make an ounce of a difference regarding upregulation/downregulation/sensitivity. We don´t even know whether supraphysiological dosages lead to downregulation, but very likely they do not. What we do know, is that high androgens decrease SHBG, paradoxically, so the higher your androgen levels the DISproportionately higher your free androgens are, so higher dosages -given receptors and gene transcription sensitivity are unaffected- should actually lead to disproportionately increased effects as your free androgens are disproportionately higher. On the other hand you could argue, that at a certain treshold of androgens, most ARs are already saturated so higher androgens lead to diminishing returns.
Summary: we don´t fucking know... But sure is that esterification does not influence it- at least theoretically.

DfromPhilly's picture

I don’t believe in receptors getting clogged. Old bro science with no actual facts behind it. The drugs we take up-regulate receptors. So if anything it would be the opposite.

Like beard says below, don’t fix what ain’t broke.

Bearded_muscle's picture

Firstly, ask yourself why you need ancillaries if you’re just replacing your natural level of test.

Secondly to your main question, you’re overthinking things. If you find a pin schedule that works for you and accomplishes your goals then great. There are some minor differences but frankly tren ace and tren e did essentially the same thing for my physique. Same with bold cyp and EQ. IF you tolerate huge spikes in the drug well, maybe fewer pins are for you. Some guys like once a week. If that causes issue, maybe you’re a m/w/f pinner, or an EOD or ED guy. But if it ain’t broke don’t fix it. You might end up breaking it.

johnmarshall12's picture

Your question is a bit confusing and all over the place. But if it's TRT the long Esters are best! A lot of people arguing to Undeconate.

felony's picture

That's called dry snitching. If you are not sure if it's against the rules then look instead of asking john. Then if it bothers you that much call him out.

Greg's picture

It's snitching if you feel your loyalty is not on the side of eroids and the best interests of its members.

If a burglar is in your house are you going to snitch him out to the cops? Of course you would.
If you were part of a burglary would you snitch out your partner... we'd hope not. See the difference?

-3 for being a burglar in my house.

felony's picture

It just rubbed me the wrong way. Don't much care for the little weiner. I see your point however my opinion's the same. Done with it. Happy cyber Monday.

felony's picture

no pics erased fuck boy. So last week you were a bitch and now your better. I know what happened after your last pct you caught the homo. no homo. Take your beady little eyes off of me I don't swing your way punk. You want a medal for signing in with neg karma okay drama queen. your like a mangy dog in the streets.lower then whale shit. now fuck outta here BOY.

Bulkdaddy's picture

Yessssssss in my Jack Nicholson voice bahahahahah

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felony's picture

Calfdaddyyyyyyyy!

Bulkdaddy's picture

Dead men tell no tales!

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Bulkdaddy's picture

Are you drunk or is English your second language

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Bulkdaddy's picture

Damn wish I could speak 3 languages...

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felony's picture

Yours all start with This is my long overdue review. Then slurp slurp slurp. Then mastino love donkey meat protein. No Homo.
Hope santa brings you the small pox.

felony's picture

Track this cock watcher.

felony's picture

Ha. He got you too!!! Think Rusty's still on the naughty list.

felony's picture

As are his Roofies apparently. I woke up in a closet with a script for penicillin.