I started using tirzepatide in May 2025 weighing 103kg and using 3.5mg per week in two doses (mon,thur), within 8 weeks I'm down to 93kg with a significant amount of fat loss and slight muscle loss.
After finding a much cheaper option I have now been using semaglutide for 2 weeks at the started dose of 0.25mg per week but weight has maintained and appetite suppression isn't as good as the tirzepatide on that dose so will be at 0.5mg this week.

it seems to be that Tirzepatide has the strongest appetite suppression, whereas for retrutide being a triple agonist is extremely effective at enhancing the body's metabolism, as well as sugar and fat utilization. Only limited retrutide studies are present right now, so it should be exciting to see.

I can only speak from experience on sema and reta, but I think it depends on your goals and what you are going for because for me they have had a much different effect.

I started with sema and I think that was perfect for me, sema has a much stronger appetite suppression factor but the margin for play before hitting side effects is much smaller. I physically could not eat at times on sema, this was good to force a big deficit in the start of my journey.

I got to a point where I needed to slow down the weight loss to prevent Ozempic face and too much muscle loss. I switched to reta. I know the max dose on reta is shown pretty high but it seems that a lot of people have had positive results with lower doses. I'm on 3.2-4.5mg a week, I've had very few side effects on reta. What I like about reta is that I can eat without ever really feeling physically unable to but I have an edge of control. So, it really seems to allow me to hit my macros.

Low dosed Reta is amazing 0.5-1mg e3d.

There’s a source on here does sema stupid cheap mate

I made a comment in another thread where I disagree with alot of Big Pharmas recommended dosing. Start low. If you have progress keep it there. Why titrate up if you are still having progress. Sure Big Pharma says 4 weeks bump it up. But why? More isn't always better. In fact a few articles are now coming out saying low is the way to go.

So many diffrent variables to look at. Reta is the newest on the market. SEMA is the original one and does what it needs to.
Quick points.
Reta targets the diffrent fats the best on the body better then tirz or SEMA.
Reta doesnt control hunger cravings as much as Tirz or sema. Meaning you will be still be hungry.
Tirz does kill cravings and has less side effects as SEMA
Tirz and sema target the same fats.
Sema is original, works likes tirz but has more side effects.
This is all based on so many diffrent studies and researching.
As far as dosage. Throw that out the window. Start small and only increase when needed, not when they suggest. If your loosing weight at the smallest dose, there is no need to increase.
Once you understand how they work, and how long they last in the body. You can actually stagger 2 diffrent ones
Shots are supposed to last a week but 5 days in they start to wear off. You can split the dose and do half Monday and half Thursday for the same one.
Example
Monday 1.25 tirz - Thursday 1.25 tirz =2.5 min dosage
Overlaps and hunger in control
Staggared
Monday 1-2 Tirz - Thursday 1-2 Reta = 3 small dose
Helps control hunger while other glp 1 helps to better target fat.
(More advanced method)

If you want more reading, online there are many other sources and even on reddit a page for woman explaining more in detail.

I help female friends get dialed in on these glps. Been doing this for 2 years now.

Semaglutide is actually very effective if used correctly. My wife have been using it for the past year with great results. After giving birth there was about 40 pounds she couldn't get rid off. I practically tried everything with her and even though she was giving 100% of an effort, she could barely loose a pound or two. After a long research we decided to go with Semaglutide and it was the best decision for her. In one year she lost a little more than 40 pounds and she feels like herself once again. There's a few tricks to keep Semaglutide working and a few things to avoid.
First, people want to get results right away and jump the gun at 1mg right away. Big mistake. You will get sick and nauseous from such a dose and shorten the life of the compound in your body. You need to start at .25mg weekly for about 1 month, then go up to to .5mg for another month and so on. It will take a while for you to get to 2mg. Once you get to the 2mg if you see that after one month results are diminishing, go back to 1mg for a week, then to .5 for another week and stop completely for a month. Then you can start again with the process once again.
One thing, my wife just want to be thin. She doesn't care about muscle. I say this because if you're looking to build muscle while on Semaglutide it will be almost impossible. Just looking at food will make you wanna puke. It makes your brain think that you have a full stomach even if it's empty and building or keeping muscle without food is impossible. Also, I have noticed that the willingness and motivation for doing exercises also gets affected because your body is in a weak state. I would never use it because of the fact that I prefer to be in an anabolic state instead of a catabolic one, but for someone who just want to loose weight, like my wife, it was indeed a powerful tool.
I can see a use for it in a competition setting when you are 4-6 weeks out. But the amount of protein sparing compounds would need to be huge in order not to loose muscle tissue.

I personally would recommend Free&Gentle Tide. It’s powerful, hypoallergenic and free of dyes and perfumes

With all the promos here and UGL, budget shouldnt be an issue anymore. Thats the benefit of UGL. I thought Sema was pretty cheap here working in a nursing home knowing what residents are paying for just the pens. And Jax i think is the best warrior out of them all

It’s so much more than a weight lose tool.
https://uk.news.yahoo.com/ozempic-hailed-fountain-youth-191057534.html