+ 3 Rapidly metabolizing test.
If anyone has been following my labs over the last 2 years with different sources then you know my theory- that I’ve been, for whatever reason, rapidly metabolizing test. This confirms it for me.
Two sources were new for me when I started using them. Both labs were done using Sustanon. Numbers just kept dropping even though I was keep dose approx same range.
Never had a bad lab with Armani so I went back to the basics. Test E 300 which someone just posted awesome numbers on. I’ve been doing 0.5ml q5 days for my TRT. I used to pull 1000ng/dL off Test Cyp 200, 1ml q7 days. This was a trough number the day I was due for my next injection. Clearly not what I was hoping for but again confirms I’m apparently just not responding to testosterone like I was and imo must be rapidly metabolizing it.
I already spoke with Armani. Told him I’d try a more frequent injection protocol 0.4ml MWF and redraw in another 3-4 weeks but I was able to get with my colleague who’s a provider and going to send in a script for Test Cyp 200. Im going to start that first and redraw in 4 weeks. Just have to try it. I’ve never been prescribed Test before so I need to cover all my bases. Not that I can imagine it will be any different as I’ve sent mass specs of armanis gear in the past and it was all legit via Jano. I’ve sent many friends to Armani over the years and all have had fantastic numbers and results.
Been using Grey Tops from Iron Lion 3.5iu once daily. Happy with those numbers of course.
Open to any of your theories as well. I’m pretty mind blown at this point. If pharma test doesn’t do it for me I may just have to come off for a while and clean out my receptors.
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I had the same issue untill I started doing subq injections. I used to do them daily but settled on 75mg eod test-e subq in the abdominal area while cruising.
When blasting I do the same, but inject some extra test and whatever other compound I'm using IM on the days im not doing subq injections (so also eod).
thanks for your testing our gh and post the test results honestly ,
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welcome, anybody to test our gh and other items and post the test results honestly, we will offer you 100$ as credit store , you can use it at any time,
thanks again
Here's my conspiracy theories:
I have to inject CYP/ENTH 3X a week minimum or else my levels tank 2-3 days in. I also have autoimmune hyperthyroidism, TPO antibodies, and NCGS (Non celiac gluten sensitivity) as well as other food allergies. I clear all drugs out of my system very quickly, including my thyroid inhibitors.
You have sleep apnea right? You may have NCGS and abnormal levels of cytokines as well. You can also cross-react to different foods like corn, dairy and other high FODMAPS (nightshades, legumes) and not even realize it. To rule this out you can get cytokine testing done, maybe your ENT can order it and have your insurance cover it, because it's expensive. Food allergy testing is useless, it doesn't show up.
You could also be having an antibody response to either the carrier oil or even the synthetic hormone. It happens to people injecting hgh, it's possible it can happen with testosterone too. I know the most allergenic oil is cottonseed, the least is peach oil. This could have been slowly aggravated over time, maybe even contributing to adrogen resistance, which is why you used to respond to test perfectly fine.
Last, there's a bunch of threads on t-nation with people posting labs work and claiming that the lower your SHGB, the faster the clearance and the more frequently you have to inject.
I have recently switched over to Test Undecanoate weekly.
Yeah folks want to lower shbg but we must understand the importance of shbg. And I agree with low shbg causing faster clearance. Not sure what ghost's issue is though. First time I've seen this to this extent.
Very interesting thoughts bro. I do have mild OSA. Hate the cpap. Autoimmune runs in my family but I’ve always been the exception with great physical health save for my injuries acquired over the years. Still don’t have any sx even of ngcs. But I have read on the shbg levels recently. I may have to include that in my next lab draw in a few weeks.
How has Nebido been for you so far? Are you doing 300mg once weekly or?
Well for me I didn't have any signs until my thyroid wigged out. Then it effected my breathing and joints and I started developing OSA. It all went away once I cleaned up my diet.
The Test U I'm using is in mct and I'm dosing it 75mg a week = 540 ng/dl midweek after 8 weeks. Going back in at wk 12 to get bloods. Will post them up.
Thanks for the info brother. Shoot me a pm and lmk your source if you don’t mind. I haven’t found nebido in jct all I see is castor oil and is rather avoid the harpoons. I’m due for labs again right after the 4th so I will post up my results on the pharma test and speculate further from there.
Damn 540 ng at 75mg. Maybe I need to try. No pip?
Great post, and it's hard to tell because you never know exactly what compounds a person is running unless you're working one-on-one with them. Winny, var, etc.. can definitely have an effect, I think, on how we metabolize testosterone.
Test flu ain't got nothing on HGH flu lol that shit crippled me for days. I found out the hard way and didn't listen to my research and started at 4 IU. If you recently ran HGH then I don't think that's a big deal but if you've taken a good deal of time off of the GH and then start high, well. OUCH. So there's definitely a reason they say to ramp it up slowly.
Some people's body chemistry can do weird things. E and C are basically the same and for most people they can Interchange the 2. For me I have to shoot cyp every other day it feels like to stay stable where as with Enanthate I can hit every 4 days and be fine. Just the way our individual body chemistry are.
I'm opposite..E is out of my system in no time. C lasts longer and gives me better appetite for whatever reason.
That's pretty rare I remember my doctor once talking about that. He said it was like three or only 8% of trt users will rapidly metabolize testosterone. I do remember him saying something about dht also but I can't remember right now. But damn that must burn a hole in your pocket when trying to blast. Bummer
I can’t find anything in the literature on it. It’s just started coming up for me over the last 2 years. I may add DHT to my next lab draw because maybe I do have increased 5a reductase activity idfk
Good thinking, let us know how you make out
The shitty reality of things is our bodies change as we age. What is it like every 7 years or so our molecules are different that what it previously was? Something along those lines. Hopefully you'll get it sorted out soon man.
Yeah absolutely. Appreciate the support bro
I see some other markers but my focus is on this situation. So I've witnessed all that you've stated up top and I'll say this, I would also do the exact same thing by using prescription test to really cover all bases and make it official. This is absolutely no knock on those srcs that you've used when you had a lower score. They all have put out good respected numbers on bloods. And yeah 289 is crazy man! Crazy situation though. Like you said you might have to do an old clean out of receptors.
Yeah man not looking forward to that if it’s the case as I’m still recovering lower body after the injury and wanted to push the upper at least having my test and IGF-1 optimized.
I understand. Hope lower body is at least getting better.
It’s been slow brother 15 weeks out now and I’m starting some movements but leg extensions still hurt. Not sure if because it’s an open chain movement or what. PT has me going back to isometric loading on single joint movements for now
Has your estro always been that low? Is free test declining also?
Estrogen has gotten lower over the years as well oddly enough. I used to be a rapid aromatizer and had to have gyno removal back in 2018. Free test is usually elevated. But I also usually run a low dose proviron (12.5mg-25mg). I stopped that to see if it would improve my lipids and it did.
One thing missing here I wish I had in the panel is LH and FSH.
Crazy situation. Yea I looked for FSH and LH but they really aren't into play right now in regards to that score. I Wonder what's happening
One thing we can pretty much assume is that your FSH/LH are essentially zero since you are injecting exogenous test. I don't think those numbers are going to provide much info. It kind of makes sense if you test is getting lower your estro would follow.
I am really clueless at this point though as to why your numbers are so low pinning that much exogenous test. Doesn't make sense. I would get an endocrinologist or urologist involved here because something is clearly odd here.
True. I agree.
I do have insurance this year I can get with a specialist depending on how this next route of care goes.
Something is seriously fucked up for this to be happening. They need to check for tumors and other shit like that, which I am sure they will. Personally, I would be freaking out if this was happening to me and want to get to the bottom of it ASAP.
Well I work in the field and have a general consensus of the main things to be wary of. Everything else is essentially normal minus my LFTs but they’re always slightly elevated due to training. At least these basic labs don’t really point to anything specific for me. I have no knowledge of any cancer that would increase rate of metabolizing exogenous testosterone. There are types of adrenal tumors that can increase natural synthesis of hormones and lead to hyperandrogenism but that’s the opposite of what I’m seeing here. There are common medications that can decrease natural testosterone synthesis (corticosteroids, anti fungals, etc) but again not relevant for exogenous hormone applications.
I would think it’s somewhere in the cytochrome P450 pathway which has hundreds of different enzymes responsible for drug metabolism.
Yeah there is no other drug metabolism pathway besides P450 in liver so you may be on to something there. Whatever it is I hope that shit is figured out. And yea tumors would totally do opposite from what I've seen. I also don't know of any cancer that would increase the rate for metabolizing testosterone.
RustyhookerAlso strange in that folks rapidly using up test are on something oral that lowers SBGH. Hes not on it currently and free test at lower end which should slow the uptake
RustyhookerObscure...celiac sprue
https://www.sciencedirect.com/topics/medicine-and-dentistry/testosterone...
Interesting. I don’t eat much gluten but I can tell you from what I know I’m not gluten sensitive. Could consider it but. I also have no real clinical
Symptoms of Celiac though. Diarrhea, weight loss, anemia, etc.
RustyhookerI hear ya. Just looking outside the box since youve got everything covered and covered again. Suggests its something obscure. We know receptors constantly refresh, binding hormone, estro etc etc. Theres findings that hcg helps on a gram or better but youre simply looking for that needle in the haystack.
RustyhookerCeliac doesnt respond to testosterone
https://www.urophoenix.com/2018/07/20/the-link-between-celiac-disease-an...'t%20respond%20to%20testosterone.