posted Mon, 08/24/2020 - 15:16
2668
+ 1 FDA changes to HCG
just got a message from my TRT clinic regarding a regulatory change to the protocols of treatment or delivery of HCG but I can't find anything online about it. They will be switching to Gonadorelin. As far as I can tell by reading, I shouldn't notice any differences. I'm on cycle now, and the only benefit I was looking for with the HCG is general testicular health. Is anyone here familiar with Gonadorelin? Thanks
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yea, its one of those things where if you are happy with your clinic it may not be enough of a deal breaker. I have a love/hate relationship with HCG because it tends to increase my E2 but I haven't seen a lot of anecdotal evidence on gonadorelin (your being one of the few i've read) to make me believe its a 1-to-1 replacement.
Molinin302Id have to get a sperm count test. As the HCG increased the volume, tremendously actually, the gonadorelin seems to be increasing the quality. I mean, its absolutely retarted to make that statement as I'm going by appearance only. But although there's less, its 100% the appearance of when I was younger.
Please correct me if I am wrong, but the HCG issue doesn't affect all TRT clinics it only affects the compounding pharmacies that make the HCG and there will be some compounding pharmacies that have the required license. I know of a few TRT clinics that still ship/prescribe HCG and a few compounding pharmacies that still make HCG.
Molinin302Correct my bro, my clinic uses a compounding pharmacy, hence the issue. And for the record, the gonadorelin seemed ok at first, may still be ok, may be better. But ejactulatory volume has decreased, but texture and appearance looks like my youth. I may be virile again which is NOT a good thing. I prefer exogenous therapy as opposed to treatments that stimulate glands. Thats just me though. Sometimes mother nature shuts things down for reasons we don't understand.
Edit- you get a +1, thanks for the input
I heard in some countries gonadorelin is used for chemical castration))
it seems to me better to use hcg, especially since it is very easy to check it with a regular pregnancy test, I mean to check even UG hcg it is g2g or not
Molinin302Thank you for your input, its much appreciated
I think the FDA made a move on this action because of all the walk-in clinics in almost every strip mall doing HCG diets! HCG is not FDA approved for diet use. Control of the situation I suppose... I could be wrong; just an assumption! I still prefer HCG over Gonadorelin. I’ll continue to get mine from overseas channels.
Yeah I agree. They tend to get a little harder when it comes to current trends and people peddling potentially harmful substances with no real knowledge. FDA's site has a lot of current news and updates if you search by drug name or ingredient.
Molinin302Makes sense to me, thanks for the input champ.
I’m gonna run an experiment in the future & run both together! That way I’m going for the desired effect using two different pathways! Seems like a win win; not sure if anyone on here has tried that before.
Molinin302Worst case scenario you grow another set of teeth, just deal with that when it happens.
GnRH-agonists will suppress you in the long term. You shouldn´t be switched to gonadorelin!!! That would act on your pituitary and not your leydig cells. Also, as you have been likely using HcG for quite some time your gonadotropes in your pituitary likely did atrophy somewhat, so gonadorelin will be much less effective. In addition HcG is great because it slightly crossactivates your TSHR (elevates thyroid somewhat) and also LHR are abundant in your adrenals, so HcG also increases adrenal hormone synthesis (progesterone, DHEA-S, androstenedione ect.). So tell them no!
Molinin302Thanks guy, this is what I thought after the other advice. I'd much rather go the exogenous route as opposed to glandular stimulation. Especially as the latter will be wreaking havoc on my pitituatary. We only get one. I'll have to call my clinic and see whats up. I can definitely tell the difference with the HCG. Before the TRT regimen I was lucky if I could produce a few drops of seminal fluid, now its pretty decent. Not that I want to have more children, but I want everything to work properly. Its gotta be better for the long term right?
also there is no way the FDA will change the regulatory status for HcG as that is widely used in gynecology and clinical endocrinology
Think of hcg as being like a replacement LH and a (weak) fsh.
Whereas gnrh's are a step before this, in the cascade and stimulate the release of natural Lh and Fsh.
Better for fertility, arguably.