Molinin302's picture
Molinin302
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I'm man enough to admit mistakes

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Well here goes, ended my cycle a few weeks ago, some long acting compounds are obviously still in my body and I'm on TRT and the ancillaries. I'm college educated (nuclear medicine) which sounds more impressive than it is, I'm currently in property management because the money is better. I've taken classes on nutrition, and felt, well feel knowledgeable. I wanted more out of this last cycle, while on the orals in the beginning i pissed off the wife, she's not into muscles, I puffed up nice. Long story short, I'm getting compliments, even today, I'm having lean showing that I NEVER have. But I've been tired. Exhausted. For my bodyweight I should be consuming 4000 calories daily to maintain, 4500 for gains that will stay. I'm well below this. Even though I'm in the best shape of my life, I'm not happy. Has anyone ran into similiar issues? I post bloods, BP results, maybe I'm an asshole for feeling this way and need a dose of reality, but as hard as I'm working, it's a bit frustrating. Thanks for having this fourum for advice, it's greatly appreciated.

Ozninjaguy's picture

It's pretty well-known that you can feel depressed after a long cycle. You have upset your natural hormone balance with exogenous compounds, and now you have taken them away, so your body is struggling to re-establish homeostasis. Do a strict PCT and wait, it can take months to get back to normal levels, particularly after a long cycle. Some people can't stand how they feel after a cycle, so jump back on cycle after a few weeks PCT. Don't go there.

Eagles 2013's picture

Agreed. Not unless you want to be on TRT for the rest of your life. But even then, true TRT isn't a cycle dose.

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Ozninjaguy's picture

Yeah, I laugh my arse off with guys saying they are on up to 200mg pw TRT - that's a cycle - not TRT.

According to Harvard the average weekly production of Testosterone for a healthy male is 42mg per week.

I'm 64 and on 80mg Test E for TRT and you can see my blood work that I have posted - almost at the top of the range. I'm actually dropping my SQ PD shots down to every second day - I don't need to be at the top of the range - just in the middle is fine for me.

So many guys (especially young guys) are using 'TRT' as an excuse to blast and cruise and never actually get off gear. Don't really care - not my life - not my body - consequences don't affect me.

"On average, healthy young men produce about six milligrams of testosterone a day." - https://www.health.harvard.edu/newsletter_article/Testosterone_aging_and...

EagerToLearn's picture

Mental health is priority nr. 1 and always has to be. The mind is all we have after all.
Chronic dieting/restricting causes your leptin levels to drop and among other things this has 3 very important consequences for your wellbeing (as leptin is a master control hormones that regulates your whole hypothalamus and also interacts directly in addition with pituitary cells):
1) your CRH & cortisol rises (and this causes your anxiety -have no better word for it- to rise)
2) it downregulates TRH and TSH and also reduces conversion of T4 to T3 in the liver (so your thyroid axes is impaired at 3 levels)
3) it directly decreases 5HT (serotonin) from your raphe nuclei (which does evolutionarily make sense: stop feeling calm and go get something to eat and worry)

My advice: slowly increase calories (about 50kcal every day) until you reach at least maintenance and maintain that for a few weeks. The energy will come back. I had the exact same issue in the past and ended up at 500kcal more then I was eating and maintained there for 2 months. Guess what: I haven´t gained a single ounce. Perhaps even lost some fat and gained some muscle. Stop worrying about gaining fat, you won´t gain much fat, perhaps some water weight.
In addition, what is the point in looking great but feeling like shit?? That completely defies the purpose of fitness

johnmarshall12's picture

It's a long story, but it sounds a bit confusing. I'm not sure what your goals are?

Eagles 2013's picture

Sometimes taking a week off from the gym is the best thing you can do. Stay on diet and don't go crazy with the booze or other "good time inducing supplements" and just rest. I guarantee that you will come back feeling better and physically stronger than you were when you left.

Also, your daily caloric intake does look a little high and you might be adding too much fat with the additional weight. If you pur on too much weight too quickly it will put unnecessary strain on your connective tissue.

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Eagles 2013's picture

I was talking the 4k calorie "maintenance" calculation. At 220 15%-17% bodyfat 4k calories is closer to the bulking range than maintenence or cutting range.

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levelup's picture

Are you weighing a logging every meal? I mean 4K maintenance is pretty high.

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levelup's picture

Regardless of anything you need rest, you are taxed. Cortisol levels are extremely high too based on the exhaustion and other symptoms. Try taking 2000mg of vitamin c twice a day for the next 7-10 days and just relax as much as possible

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EagerToLearn's picture

Actually I think its the other way around. he was taxed for a long time (cortisol levels being high).
After some time CRH and the pituitary corticotrophs adapt to a new setpoint which causes downregulation of the HPA and the free cortisol levels are actually LOW and not high (this is what is commonly known as adrenal fatigue but has nothing to do with your adrenals but everything with your hypothalamus).
This is the biological correlate of a burnout.
VitC or any other stuff won´t help much, as they target the adrenals, which aren´t the issue though.

there are some things that help:
1) remove the stressor (in your case the hypocaloricity and perhaps life stress). Then all you got to do is to be patient (and it usually takes a few months for the HPA-setpoint to normalize again...)
2) in the meantime to speed things up you can try some adaptogens (rhodiola or ashwagandha -I would advice to alternate monthly) which slightly raise your cortisol levels to much more normal levels if they are low (as both of them are serotonergic).

levelup's picture

Adrenal fatigue isn’t accepted in the modern medicine field
Blood test - guaranteed it’s high

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EagerToLearn's picture

and a cortisol test doesn't tell you shit due to transcortin. you need a super expensive free serum cortisol or a 24h free urine cortisol. and there is no way to "guarantee" whether it is high or low just by diagnosing over the internet, however my educated guess is free cortisol is at the bottom or rather low. chronic fatigue syndrome and burnout are both associated with low free cortisol, basically the only common biochemical abnormality in both

EagerToLearn's picture

The same way your HTPA can downregulate after some time of high androgens or your thyroid partially shuts down after exogenous replacement or even endogenous overproduction so can your HPA after chronically high cortisol levels -and all these adaptations are of central (i.e. hypothalamic-pituitary) origin. Doesn't matter whether endogenous or exogenous. and as said, ADRENAL fatigue doesnt exit, but hypothalamic does

levelup's picture

Maybe I’m wrong but if acth is released during periods of stress and cortisol is released to lower acth then it seems to me if he continues to stress his body more and more cortisol will be released...I just don’t understand down or up regulation is the feedback loop. But I studied ecology of biochem so it could be that my understanding is limited

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EagerToLearn's picture

Yes CRH is released in times of stress, which then releases ACTH. But after chronic CRH-release the system is "set" to a now lower setpoint and your baseline cortisol is much lower, causing you to be depleted of energy. Cortisol is actually a hormone that feels you good and energetic and having low cortisol levels causes you to feel like shit and crap, much more so compared to all the other hormones (e.g. hypothyroidism, hypogonadism). Cortisol is only a problem if it is elevated for a long time...and this in some people causes downregulation of the whole HPA, adapting to lower baseline values. This usually happens after months and years of chronic stress associated with high AUC cortisol (which is equally bad). And when the system has set to a very low baseline activity this is the equivalence of a burnout. Many burnout patients are treated with low dose hydrocortisone (their cortisol is replaced the same way thyroid or testosterone is replaced) and without it they feel like shit and have no energy and dark circles under the eyes ect.

fusebox's picture

+2. Great explanation

levelup's picture

Might be time for some more in depth testing for my levels...thanks for the clarification

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EagerToLearn's picture

I am well versed in endocrinology and also in how to test for specific syndromes and their etiologies. If you have any questions shoot me a FR and PM me

levelup's picture

Is your background in biochem?

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EagerToLearn's picture

Yes, but any guy on the internet could say that Smile Actually molecular biology

levelup's picture

Lol I figured bc of your explanation I guess I just don’t fully understand the mechanism

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EagerToLearn's picture

Nobody does. Either it happens within a single cell due to epigenetic modifications or at the neuronal circuit level involving LTP/LTD of the synapses involved... or both.

press1's picture

I get that Lol ...

levelup's picture

There are some decent cortisol products out of the vit c isn’t handling it - guerilla chemist makes one

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Forehead's picture

100% with those other posts take a break when you can.

levelup's picture

You need a week off the gym...relax. Let your cortisol levels come down, give your mind a break. Have a few cheat meals...it’s time to reset

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Bill1976's picture

He’s right. When I feel like shit and tired and stop making gains I take ten days off and come back wanting it again. Matter of fact this is my 11 day off and I’m going to the gum around 8 tonight.