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i20bpm
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+ 7 Glucophage/metformin? Everything & Anything

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Glucophage/metformin
Metformin is a widespread type II diabetes drug used by those who have diabetes or are at risk of suffering from this condition, such as obese patients. In addition, it helps reduce low density lipoprotein (LDL) cholesterol and suppresses glucose production in the liver. Currently, it is listed in the World Health Organization's (WHO) list of essential medicines.

It belongs to a group of drugs called biguanides, a group of antihyperglycemic drugs. It increases the transport of blood sugar across the cell membranes into muscle cells. The action works by positively effecting cellular insulin sensitivity.

Bc of this it's had a place in bodybuilding for sometime now. But new claims suggests it has a life expanding effect as well. The link is below. http://www.medicalnewstoday.com/articles/280725.php

Now let's get to the nitty gritty. I'd like to hear from other members who have ran this with success. Is it safe, worth it? Dosages etc. I'd like to hear it all, perspectives and everything.
I've seen some old posts on this but nothing too recent so it seems like it is fine to talk about this drug in forums.

i20bpm's picture

Nice thanks man, damn it reduces testosterone up to %60 after a few weeks. Good thing for exogenous test

i20bpm's picture

Yeah the article says that as well

Makwa's picture

I don't know why met doesn't get more love. You see all these whackos running T3/clen stacks to lose a little fat and all that combo does is burn up muscle tissue along with it and can do some serious long term damage to your pituitary. Some strategic use of met would be much safer and more effective and spare the lbm.

I have used met for both bulking and cutting. I would say it can be an effective compound but I would't call it earth shattering and attempt to sell my first born just to get some. Depending on whether you are cutting or bulking will dictate on how you dose it and the timing of it. First off, I would like to throw out that that those of you who are doing all of this long-term GH stuff should proabably be running short cycles of this stuff every once in a while. Why is that? Well, we all know that GH use, especially long term use, will cause insulin resistance. To combat this, it is pretty easy and safe to run say a 4-6 wk course of met to help reset your insulin sensitivity. IGF is another way to reset insulin sensitivity by the way also.

Now as for bulking with stuff, it can definitely provide some advantages. One of those prime advantages again is to reset your insulin sensitivity. One of the problems with eating a cal surplus is that eventually your insulin sensitivity will take a dive and then basically all those cals start turning into love handles instead of muscle. When that happens, it is time for an insulin reset. Run a four wk course of met or do a mini cut and insulin problem solved. As far as doses of this stuff, about a 1000mg/d is all I used when bulking. You want to take it with your largest carb containing meals. The rule of thumb that I have seen is about 100g of carbs for every 500mg of met. This is pretty much what I followed. I would take my 500mg dose (or split an 850mg pill) and take with my stack of pancakes and syrup for breakfast. Your muscles will blow up after this also, since it shuttles all those carbs into your muscles. Then I would take my other dose with another high carb meal, usually my post-WO meal. I never ran it for more than 4wks at a time and basically took just as much time off before running another course of it. One thing to note is that it can kill your appetite and be sure to have a bathroom nearby until your gut gets used to it.

Now when cutting, I pretty much use it for the same purpose, to reset insulin sensitivity, to keep the fat burning process accelerated while cutting. This time I dose it different than when bulking. I pretty much dose it evenly throughout the day. 3 doses of 450mg seemed to do the trick. Usually something like breakfast, lunch and post-workout. Goal is to keep a steady supply in your system. Also, if you are one of these ketogenic fools, this compound can get you over that hump and into ketosis alot faster.

Bottom line is it is a pretty versatile compound that can keep the fat off during a bulk and partition more nutrients into lbm and it can accelerate the fat loss during a cut. Not sure why more people don't use it though.

Emperort's picture

It can cause metabolic acidosis, that inhibit protein synthesis, it also causes nausea (and if you're predisposed to it like me it's very annoying). Then diarrhea for the first weeks. Maybe I'll put in some metformin on my next cut cycle (without aas) but I'm not sure because of sides...

i20bpm's picture

I believe That's why you run b12 with it and that is the effect that drops your b12 so running b12 would mitigate the lack of protein synthesis

Emperort's picture

Do you mean b12 inj or oral?

i20bpm's picture

What does the method of ingesting matter it's the side effects of it. Yeah one maybe better than the other but that's not my point. You got me a little confused by that response

i20bpm's picture

Yeah I imagine that you'd be right, dude just got me confused talking about diff things post to post but that's what happens when you are trying to do 9 things at once and trying to appease your 3yr old son lol side note he works out with me with little 2lb weights and his shoulders are capped already at 3 lol I took a pic of them wish I could post it blurred but I think that's too off pudding

i20bpm's picture

Oh I do bro, there's not enough time in a day

i20bpm's picture

Another thing is did you monitor you blood sugar levels when running it

Makwa's picture

No

i20bpm's picture

I'm assuming it's just not necessary

MedDx's picture

Probably not necessary, but then you're leaving yourself open for unanswered questions in the event you want to know what your blood sugar is running based off potential signs and symptoms of administration and dosing. I would want to know what my blood sugar was running, especially if i was a first time user. Therefore, I could get an idea how my body responded to the drug. Dosage of drug and CHO intake, probably on a cut, would make better to sense to monitor blood sugar in comparison to a bulk. And, if I was utilizing high carbs on a bulk, the concern for high dose met would be relative to body response with CHO intake, and I'd be more concerned about how low the hypoglycemic agent was controlling me, especially if met dose was 1000mg. However, I'd monitor either way, just to know, but I wouldn't spend tons of money on strips to do everyday monitoring, either. Just be safe... Smile it seems like a relatively safe drug...I've administered to a lot of old people on low calorie diets and never saw a blood sugar too low, or too high out of a range of 60-120.

i20bpm's picture

Yeah that makes sense more so in a calorie deficit and of course it's always better be safe

MedDx's picture

You're awesome bro...thanks Smile

i20bpm's picture

Awesome you pretty much just answered all my questions that I can think of in that one post thanks for commenting bro

Pale's picture

I ran it all of last summer. I did lean up a little more than maybe I otherwise would have, but I also seemed to be much more heat sensitive as well. Lots of heat-stroke headaches last summer. Then when it came time to come off is when the fun really starts.

I normally have had an iron gut, well after metformin for several months I suffered frequent acid reflux and all that crap. Nothing like waking up just as you get a mouthful of stomach acid to choke on. It did get better again but I still occasionally get reflux where I never had had it before the metformin.

MedDx's picture

Was your dose and frequency high and how long did you admin it...

i20bpm's picture

Hmmmm, the heat aspect concerns me a little bc I work outside and well it's summer and hot as hell lately and the acid problem sounds shitty. But all in all you would say it just made you leaner?

MedDx's picture

I agree...I've seen some old posts on it too! Makwa has some awesome info on it, somewhere.

Some of the info in your post, makes me want to incorporate it into my next cycle of test only, especially if it helps with lipids and insulin sensitivity.

500mg is the dose, but I wonder if 250mg, or less, could be therapeutic?

i20bpm's picture

I was just reading about l cartinine and it has some of the same effects in terms of glycogen and all the way down bottom in this link it talks about how it can reduce lactic acid. Wonder if they can be taken together.

www.bodybuilding.com/fun/your-expert-guide-to-l-carnitine.html

MedDx's picture

I take COQ10 with that in it...

i20bpm's picture

My coq10 is just that

i20bpm's picture

Yeah chloresterol and all that ik it is interesting which is why I want to get more info on it before I give it a go bc knowledge is power. But I wonder the same about dosages, need to get makwa in here to say his piece

MedDx's picture

I remember seeing something about 80g carb days during a cut and incorporating Metformin with it, then maybe having to titrate back up to 100g. I'd definitely use a glucometer, while administering met. I've had patients use this drug 500mg in a.m. and 500mg in p.m. keeping steady blood sugar levels of around 100-120. Now their diet was like nursing home food and not very much at that, plus they were considered to be sedentary and or minimal activity.

i20bpm's picture

Yeah it's good for cutting purposes mostly it seems

MedDx's picture

I'm betting we can get some good results from using it too...I'm digging in my books...here's wiki

https://www.google.co.uk/url?sa=t&source=web&rct=j&url=https://en.m.wiki...

i20bpm's picture

Yeah Darth I mean sauron lol posted his experience up top

MedDx's picture

I recapped on it and I'm not done...I believe you need to be well hydrated, while using it, plus have a specific time frame for admin. Def makes sense with what Sauron said.

MedDx's picture

https://www.google.co.uk/url?sa=t&source=web&rct=j&url=http://www.medsca...

Another link for info regarding met...

Get pre cycle BW and make sure your eGFR on the CMP meets the parameters prior to taking...

i20bpm's picture

Interesting

i20bpm's picture

Yeah what I read said it can cause some gastrointestinal de-stress but if taken with food it negates a lot of that.

Makwa's picture

Explosive diarrhea. lol

MedDx's picture

Lower doses are better to start out with as long as eGFR meets the parameters... >60...

MedDx's picture

You can be dang sure if I use it, it's gonna be a low dose...any flatulence and the frequency is getting spread out and the dose decreased... Smile

MedDx's picture

Right..lol.. Smile

i20bpm's picture

Lol really? Ahh man is it like an hour after you take it is when it happens?

Makwa's picture

Your gut gets used to it after a few days. I usually noticed my gut gurgling an hour or two after taking it.

i20bpm's picture

That tells me I should start on a weekend lol

MedDx's picture

Lol

Pale's picture

Definitely make sure it is with food. I made the mistake of taking on an empty stomach one night after I missed my usual time. Violent puking was the end result.

i20bpm's picture

Damnnnn yeah I'd rather avoid all that bs, lol all good pointers in this thread I'm glad I asked

MedDx's picture

Yea that lactic acidosis producing lactate seems like it could present a challenge...food and water may offset...it said it was more of a base, than a acid on the pK scale...

i20bpm's picture

Yeah but doesn't taurine help with that?