All depends on what your goals are. If it's muscle gain the only way I've found it to be a muscle builder by itself ( without using a unecessay potential dangerous drug) is a large dose post workout and a large dose before bed. Remember you grow when you sleep. If your goal is just anti aging and some fat loss and you have real pham grade gh 1 shot a day will do the trick. 2 would be better. 3ius total would be great for anti aging and fat loss.

I use 5 Iu Ed upon waking I use 2.5 Iu I'm for instant growth releas and in the evening I use 2.5 sub q for long release whe sleeping

Rocco,
My experience with HGH, and it's been quite extensive.. is to take it in the following manner.
Start with 4iu per day..

Take 2iu pre workout in the muscle you're going to train (bi-laterally) so if you're training legs take 2iu in your right leg before the workout.
Then 2iu post workout in the muscle you have finished training (bi-laterally) so if you've trained legs take 2iu in your left leg post workout..

The more advanced Guru's in the game are using this method with incredible results. Not only does it help increase blood flow and create some kind of site response in the muscle you're training that day but it also seems to optimize recovery.

The only area you will not be able to hit is back, unless somebody pins for you.. So on back day just hit that bodypart which is your weakest.. If it's arms then hit arms again.. This is in my humble opinion the best route for growth when using HGH.

Dr. Roids

If your doing 4ius your best bet would be 2ius morning and 2ius before bed.