"Replacement" Dose?
A few times in the forums I have seen people refer to low doses of GH, around 2iu/day, as being only a "replacement" dose and not of much use. Now, its my understanding that unlike when we administer exogenous testosterone, our natural GH production does not shut down. So lets say a normal person produces the equivalent of 4iu GH per day(no idea how much GH we produce, just using a number) and also administers 2iu/day of exogenous GH, would that not be a 50% increase as opposed to a "replacement" dose of 2iu? Whereas someone who is deficient in GH and only produces the equivalent of 2iu and also administers 2iu of exogenous GH would be using a replacement dose.
I hope that made a little bit of sense, curious as to why that term is used when referring to low doses.
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replacement would be 1iu-2iu pharma I'd go 3 or 4iu with generics
I read somewhere that the average teen is 1.5-2.5iu/day or higher and adults is about 0.5iu-1.5 on average decreasing with age increase.
So yea 2iu is upper end of replacement if using pharma, or 3-4iu others.
AnonMy step son is 11 and takes it for growth deficiency. He is no currently up to 1.8mg/5.4 ius of pharma
Yeah that's definitely a replacement dose. Sounds like an extremely conservative doctor.
Anonhe is expected to go higher, he started at 1mg/3iu and they have been working his way up
What time of the day is it administered? Curious about night/morning and its potential impact on our own GH production. thank you
Anonhe takes it at night, but thats because he is not producing any of his own,hence he is not growing. I ask the Dr. myself "Why not take it in the AM so he doesn't effect his natural production". His reply was"He needs it as a replacement, he is not trying to add more to his existing like baseball players do". THis came from someone who works in GH deficiencies. So this is why i dont take mine at night.
Thanks for your reply!
Anonanytime
Thanks for your input, I'll stick to my AM injections.
Anonno problem brotha, sent you A FR
accepted.
Dude, I can tell you have put in a lot of time and research into HGH here recently. I've seen you around on several SI's and you have been asking all the right questions. I was actually even bragging about you to another bro on here and told him to get in contact with you cause he had several questions on the subject and I told him you were the man. + 1 for the work you've put in and the help you've provided.
Thanks for those numbers J, but why is it "replacement" if we are merely adding to our own production? If we use your numbers and say we produce 1.5iu/day, then we administer another 1.5iu/day from an exogenous source are we not essentially doubling our total GH and not really "replacing" anything?
I would use the term "replacing" with someone who has a GH Deficiency. I think the term replacement doses get tossed around lightly because there treating it as if it were trt or comparing it to when really it isn't the same at all
Thats pretty well what I was trying to get at
Hgh will shut you down for around 12 hours so if you was to take it bright an early in the am an then right before bed being that it doesnt shut you down right after you inject if im correct you can still take advantage of your natural GH sput at night
would be interesting to know how long post injection before it actually shuts one down as the big GH pulse at night usually happens during the deep sleep if Im not mistaken and that is usually a couple hours after falling asleep I believe. Timing would be everything I guess.
I don't know for sure how long as I've heard different numbers around the 2-3 hour range before shut down but I'd say ya timing is everything, Id have it beside me while laying in bed when I started nodding off id pin it lol
Edit.
Because for the body to maintain homeostasis, our body responds to injected HGH. In other words, say you naturally produce 1iu per day and you add 2iu exogenous you have a total of 3iu? No because your body will just reduce the amount of naturally secreted growth hormone. So your body will reduce that 1iu to 0.5 giving you a total of 2.5iu GH in your system.
Of course those numbers aren't accurate or mean anything it was just an example.
Similar to say if you have a natural testosterone level of 600 you inject 100mg of test now your levels are 1000 because your natural production decreases due to the exogenous test in your system.
Injecting hormones causes suppression of your natural hormones
Interesting, so regardless of injection timing , whether it is administered in the am or in the pm near that big natural GH pulse during sleep , we are to some degree blunting our natural production of GH.
I honestly couldn't give you a straight answer bro. I've been doing lots of research and find conflicting theories.
Some believe GH suppresses for 24 hours
some believe you can inject early am and your PM sleep GH release will not be suppressed.
I personally believe if you inject very early in the day, you will still get some suppression of your natural GH pulses through the day, but your night time pulse will still be relatively strong. A little suppressed but still significant.
Of course this is dose dependent. 1-3iu in morning will not cause significant suppression (in my opinion). But 10 or more iu's on the other hand will cause more suppression.
My first post here... Been doing some research on HGH with an intention to start my very first HGH only cycle later this year. Also, would like to say that I very much appreciate everyone's feedback and active contribution on this forum...
Back to this topic... Exogenous HGH injections and its right timing has been on my mind lately too. There seem to be several threads here that refer to this topic but so far have not seen anything conclusive. It seems that many here prefer am injections and it has somehow become "the norm" among HGH users.
Just recently spoke with a friend of mine whose son is 9 years old and has received HGH for several years now (autism, lack of physical growth etc). He mentioned that their injections are always at night right before bedtime. It seemed interesting to me. His comment also was that his son's own HGH production is still "alive" but not simply producing enough to allow him to grow normally. With exogenous HGH, they simply keep his GH levels at the upper end of what's considered normal for his age.
My question is this: If evening injections completely shut down kids/adults own GH production, why would the doctors suggest that? Saw another link on this forum (http://jcem.endojournals.org/content/85/2/601.full) where 20k and 22k HGH levels where discussed and how exogenous HGH injections did not suppress endogenous hgh production before 4 hours after administration Again, this might not be apples to apples as pointed out in the thread but would explain why my friend's son gets his dose always in the evening. Any comments?
Sorry about the long post.
Dont be. Great 1st post and thanks for the link. +1.