Im starting to realize that exercise and then having blood work done really has an effect. I nearly always would have Leg Day on Fridays and then on Saturday mornings bright an early before being hydrated I would have blood drawn most often just because it was always my "trough" and worked out best in my schedule. However I would notice issues with my ALT being high or creatinine being very high. Next blood work Im getting much larger panel and making sure I am well hydrated and nothing for atleast 2 days prior.

Brother, I’ve honestly never seen SLU cause issues in biomarkers … if anything, most guys report improvements across the board.

SLU-PP-332 itself isn’t known to be directly hepatotoxic from the limited data we have. It’s a PPAR-δ agonist, so in theory it influences lipid and glucose metabolism more than liver enzymes. That said, it’s still a research chem… purity and dosing are always a question.

Did you see an HPLC test for this SLU?

There are people blending AICAR and T3 into their “slup,” so you definitely gotta be careful…

They’re cheaper molecules and can give somewhat similar effects at first glance, but the long-term outcome is completely different … especially when it comes to biomarkers, recovery, and overall stress on the body.

AST at 80 before and now significantly higher? A few things I’d consider:

Heavy training can elevate AST (it’s found in muscle tissue too, not just the liver).

Test + very intense sessions + dehydration can bump it up.

If ALT isn’t elevated proportionally, it’s often more muscle-related than liver-related.

Now, if ALT is disproportionately high as well, then yeah … either the SLU is contaminated/mislabeled(or it’s not SLU), or something else in your stack is stressing the liver.

Did you run any orals recently?

First thing I’d check:
Was ALT elevated too? And did you train hard 24–48 hours before the labs?

If you really want clarity, pull the SLU for 3–4 weeks and retest. That’ll tell you a lot more than guessing. Honestly, that’s the smartest move you can make if you want solid, real answers about it.

Hey man, I went through an AST and ALT scare a few months back with accidently over doing GHK-Cu (incorrectly reconstituting the vial). This schooled me up real quick on how to get my levels back within range. Here's a breakdown with some insight. Best of luck getting back to optimal levels!

If your AST is elevated much more than ALT (like AST 137 with ALT 49 in that screenshot), the #1 “boring but common” explanation is muscle, not liver.

Most common reasons AST runs high

Muscle / training-related (very common)

Heavy lifting (especially legs/back), high volume, “new” exercises, hard conditioning

DOMS / muscle damage

Even things like long runs, BJJ, CrossFit

Rhabdo spectrum (rare but important): extreme soreness, dark urine, weakness

Alcohol can push AST up (often AST>ALT), especially if there was drinking in the prior 24–72h

Medication/supplement effects

Some supplements can irritate liver or be contaminated/mislabeled.

Testosterone itself usually isn’t as hepatotoxic as oral AAS, but it can still contribute indirectly (and if he recently used orals, that’s a bigger flag).

SLU-PP-332 is an experimental research compound marketed as an “exercise mimetic.”

5-Amino-1MQ is a research compound sold as an NNMT inhibitor; human safety data is limited and product purity is a real variable.
So: they could be involved, but the AST-dominant pattern still screams “check muscle” first.

Hemolysis (blood draw issue) can falsely raise AST.

Clues from his panel (in your screenshot)

GGT is normal (10) and bilirubin is normal, which makes a “blocked bile duct / cholestasis” pattern less likely.

Alk Phos mildly high can be liver or bone/training-related; GGT helps interpret that, and his is normal.

Practical next steps:

Repeat labs after 5–7 days with no hard training, no alcohol, good hydration.

Add CK (creatine kinase) ± LDH (these help confirm muscle source).

If still elevated, add hep panel (hepatitis A/B/C), iron studies, consider ultrasound, and review all compounds (including “research chems”).

Red flags = dark urine, severe muscle pain/weakness, jaundice, right-upper-quadrant pain → urgent evaluation.