pg/ml is the measurment im firmiliar with and 186 pmol/l equals about 51pg/ml. If I was on cycle and my goal was pure muscle gain (bulk) I wouldnt touch that adex. Id maybe add some proviron. Estrogen is very anabolic, many tend to forget that and try to keep it low like in the 20s etc, thats fine for a cut, thats what I would do when im cutting and trying to lean out and stay nice and dry. But when im bulking and pushing heavy weights that extra water from the e2 is going to cushion your joints, so you can push more in the gym, leading to more muscle, its going to make you stronger so you can lift heavier equaling more muscle, and like I said, estrogen in its form is anabolic, without it you wont grow, with to little youll hinder your gains. If youre suffering from any problems due to higher e2 like libido problems, high bp etc, then id lower it, but if not then I wouldnt mess with it. If you insist, add .25mgs twice a week, that will be enough to bring you down in range. But personally if im bulking i let mine get up there, yours is 50 i let mine get up to 70 at times when bulking. But when cutting and trying to keep a dry lean physique i go heavier on the ais, But thats the only times.