exrix39's picture
exrix39
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+ 1 PSSD/PFS/PAS Possible Cruise?

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Hey everyone,
I'm gonna need a long preamble here to fully explain my situation and make an earnest, last-ditch request for help. TLDR at the bottom.
I've taken SSRIs (literally every one that exists at months-long minimum for the one I took least--I'm talking Paxil, zoloft, prozac, celexa, lexapro, viibryd, etc.--cumulatively for too many years and almost never any time off in over a decade and through formative years), other psych meds (all for resistant anxiety/depression), done TMS (transcranial magnetic stimulation), ketamine infustions, taken finasteride in oral and topical forms for a cumulative year (topical definitely still goes systemic to a degree), used topical retinoids, and gotten COVID. COVID, accutane (I did not use accutane, but topical retinoic acid--can it cause issues like post-accutane syndrome in susceptible individuals since it's a retinoid? I don't know, but who does?), finasteride, and SSRIs are known to contribute to a similar network of symptoms in rare cases--low libido, cognitive issues, anhedonia, sexual dysfunctions of varying type and severity, sleep disturbances, and more. I have severe ED that doesn't respond to PDE5 inhibitors at a relatively young age with no other determinable causes, diminished orgasm quality, likely reduced sensitivity but it's been so long with these symptoms I don't know what normalcy in that department is (I can do as I like with my dick, it's not that thrilling and I can take it or leave it at any point during an attempt at masturbation--there is no mystical point of no return until orgasm as it's...lackluster), sometimes can't orgasm at all, complete and utter anhedonia, immense trouble sleeping, basically zero emotion except for fear and aggravation, etc.

I can't say what caused what, but SSRIs are the most likely culprit the way I've been through them, and things dipped a bit after getting and recovering from covid. They also dipped sharply after SSRI discontinuation, but the symptoms were already there on SSRIs. Doctors are dismissive and inattentive in any specialty (i've been to many at this point) once basic first-line interventions are tried, and I've self-experimented with relatively safe options and supplements besides more severe AAS. I'm healthy on paper to any medical professional. Healthy dieting, fitness, and the passing of time with a can-do attitude while living on zero RXs of any kind has offered positively nothing.

The only improvement I saw, and it was fleeting and insufficient overall, was TRT + HCG. But it gave me a glimmer of hope nothing else has. I've let E2 ride high and lowered it drastically, and everything in-between with arimidex: no dice. I've dabbled in proviron from various sources and it's offered nothing positive, unfortunately. I've played with dosages until reaching low e2 symptoms. I did notice a surge of libido from dianabol after a few days, which quickly died out after likely the methyl-E2 from it flew too high, and blood pressure + RHR felt unstable + anxiety. I know it isn't entirely safe, but I do know people can live relatively long lives blasting and cruising with numerous compounds while enjoying heightened sex drive and function, mentality, etc. I don't want to blast grams of compounds or develop an incredible physique. Like that'd be nice, who doesn't want that, but it's not my priority. But I do know I'm gonna need something besides testosterone and hcg to find my way, if it exists at all. Does anyone have any recommendations for an unconventional cruise? My thoughts trend towards trestolone with test and maybe masteron?

TLDR--I've got sexual and mental dysfunctions induced by medications that lower my quality of life to an extent I don't and can't approve of tolerating without trying every last avenue of possible improvement. I'm gonna need a cruise stronger than TRT + or - HCG.

Thank you so much in advance for any guidance at all. And I'm no longer on any of the causative medications.

Crispymylk's picture

Ok I'm probably the only one who knows EXACTLY what you are going through, I took Prozac at 40mg Ed for months it was miserable, dropped me down to 20mg and that was my standard dose for probably a year, had absolutely no feeling in my dick none

Finishing didn't feel like anything, absolutely no penile sensitivity whatsoever, switched to 10mg of Lexapro and for a short while it was like 2% better

Went through serm therapy because my numbers were low and that yielded boring results so I hopped on TRT on my own then got it prescribed and it didn't do anything for my sex drive, sure I got erections and really good ones 8 times a day but nope still no feeling

That was until I touched the love of my life NANDROLONE, no idea why no clue

140mg of test a week split into 2 subq( throws me over 1500 so it's enough for an easy cycle I thought), started at 200mg deca and when it kicked in I kid you not all I could think about was milfs it would make me literally drool it felt like I was 14 again lmao 3 sometimes 4 times a day

Bumped my dosage to 260 which I shouldn't have done but oh well, acne started to emerge on my back only and enough to be like oh, sex drive started to plateau a bit, end of the cycle coming up 25mg of winstrol was added and my sex drive came to a hard stop with winstrols addition

Problem is my bacne never went away and it's been 3 months, it just keeps coming so I hopped on finasteride which helps a little because I make an F ton of DHT but really my prolactin is elevated and in turn that's increasing my 5-ar but whatever I'll handle that later

My theory is since both ssri and 5ari lower dopamine you are in a state of dopamine suppression like me

AAS have shown to significantly increase dopamine in rats, pick your poison if this is the rout you want to go

Personally I'd say 50-100mg nandrolone a week but keeping your e2 in check will keep your prolactin in check unlike me being dumb with no ai because I never needed one with test

I bet if you got a prolactin and catecholamine test it would absolutely be skewed

Jockstrap's picture

Roids are not a good choice for everything you listed

Rosschestzip's picture

Test and mast. Idk how effective it will be for you but it’s definitely where I’d start. Also I’d go with test prop and mast prop so your not waiting weeks.

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exrix39's picture

Thanks so much for the reply. I've heard mast works really well for people in the libido and mental department, and I've seen people discuss using it as part of a cruise while keeping in decent health long-term. This is probably gonna be the first non-testosterone steroid I'm going to give a try. The next thing I'm going to try, period, as I've been on the highest dose you can still call TRT for a while now. I'm just hesitant to get too excited about any DHT derivative seeing how Proviron totally failed to induce any positive changes in me, and people seem to praise it as much as I've seen anyone recommend masteron. Then again, they're not DHT itself and may very well have varying effects as far as I know.

Rosschestzip's picture

I think proviron is also misunderstood and only had benefits in some people. But yes masteron is also one of the only steriods I’d recommend using longer term. And proviron is so much weaker then the masteron would be even though masteron is also considered “weak” so I wouldn’t lump them together. How much test have you been using? You may need to do more than what people would consider trt. Even if it’s just to try it out

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Steeltoad777's picture

The test /mast combo is great. Have you tried test no ester? Since you're trying any/everything... Maybe trt with or with out mast, then before sex pin 25-50mg of test no ester, stacked with some Viagra?

Just throwing out ideas.

Maybe it's mental block? The fact that you've helped the problem briefly when using dbol and testosterone tells me it's more of a biological vs neurologic problem.

How did ketamine work for your mental state out of curiosity. for me better than anything else.

Psychedelics are amazing. There was an entire year where I couldn't cry. I was depressed stressed out etc, id get emotional to the point where I felt like I was about to cry but I just couldn't. I'd try but tears wouldn't come out. I used some psilocybin and the flood gates opened after I came down. Relieved a shitload of stress I had pent up. That shit is real. But your situation sounds more like you've got some hormonal thing going on.

I hope you find something that work!

exrix39's picture

Thank you so much for the reply. I haven't tried no ester, no. I've just been doing TRT with testosterone cypionate at 200 mg/week split into two shots every 3.5 days with varying amounts of HCG, from 500 IUs a week to my current 1500 IUs. With no ester, I'm guessing the sharp peak in test levels might provide a libido boost? As far as viagra, it does make things easier, but no PDE5 inhibitor on its own is enough to get me back to normal, and that's with daily 20 mg cialis on top of occasional viagra or levitra.

It's definitely biological for the most part. I'm undoubtedly going to have somewhat of a mental block after all this for the rest of my life as a result, but I can be utterly comfortable and alone, watching porn I know I would normally be excited by, taking cialis and...I can get it up with enough attention and focus, but it'll go back down instantaneously if I so much as move my hand away for a second.

When I took ketamine, it was while on SSRIs to help anhedonia that was already settling in. Hobbies of any kind were just lackluster for me. I did an infusion and I noticed an improvement after a couple sessions. And I felt more positive. But as they dragged on, anxiety began to build as, for whatever reason, it'd send my blood pressure soaring while under the effects of it. I'm thinking about giving it another go and trying out psylocybin, for sure though.

Chad P's picture

Have you looked into pt141 peptide for the ED low sex drive?

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exrix39's picture

I've tried it, actually. It's been hit or miss. My first source was iffy, second came a little better recommended. On the first injection, I noticed a boost in sensitivity for a few days, but it was nothing mind-blowing in terms of any erectile improvement. The second injection boosted erections suprisingly well. I got an involuntary erection that lasted 3 minutes while walking around. Which is a big deal as standing usually wipes out an erection from laying down or sitting rapidly. Sensitivity improved and so did libido slightly. But the second injection's benefits wore off rather quickly. Both injections were at 2 mg, subQ.

I'm also afraid of regularly using it. I'm prone to anhedonia, apparently, and there are anecdotal reports of people getting long-lasting anhedonia after PT-141 on occasion that I've seen. And more often that long-lasting, people get anhedonia or a general low mood for a few days. It plays on MC4Rs and this paper: https://pubmed.ncbi.nlm.nih.gov/22785313/ concerns me. I'm iffy on it overall.

Rosschestzip's picture

I was gunna say that too. Like I had said to you before, I heard it’s kinda extreme but that sounds like what this guy needs

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