This is actually a very good question, I've wondered myself about this.... I recalled someone preferring to shoot your GH in the morning and Early evening because the body would pulse the most while you sleep so shooting it bedtime was not efficient... I want to say Dave Palumbo if I remember. I know you will get shut down temporarily but how long i do not know. @Bearded_muscle has a very good explanation and has opinions I believe are valuable. One of us that knows there baseline should do this expirement, run igf-1+ serum GH levels find out baseline, hope on GH for a week test again and then test 24-36 hrs again off GH

I'm not sure either but good topic. Some info to share since your header says natural production.

According to research these are great supplements to enhance your own natural production

Arginine is good
Arginine + lysine. Best. According to an older study
Gaba is very good
Creatine, decent
Ornithine, decent
Glutamine 2 grams, +78% increase very good

Obviously less sugar intake, less body fat, aerobic exercise, fasting, more sleep, melatonin

Although my reply doesn't have much to do with your topic or what you're asking I just wanted to share and I figured this was a good opportunity

You can Google any of these and they are just different ways that you can get your own natural production enhanced

+1

I've always read your natural production is shut down for at least 24 hours post injection, this is why guys like to take it before bed time as it mimics your bodies own natural HGH secretion or as close to it as you can get. But its not like steroids where its shut down for weeks or months afterwards as such.

i was always under the bro science assumption if you’re splitting doses to hit your first dose in the morning and your second dose in the afternoon so by bedtime your natural production kicks back in while you sleep. that’s what i’ve been doing the past several months.

Natural production is shut down for at least 24 hours, probably closer to 36.

We have studies showing shots taken 4-6 hours prior to bed and your natural nighttime pulse basically goes to zero.

If you’re running 2 iu take it before bed, we see better utilization and igf1 conversion pre bed which makes sense because that’s when we’d be producing the most naturally so the body is really primed to use it.

If taking more than 2 iu split doses half first thing in the morning and half before bed, or half pre/post workout and half before bed.

We know that after cessation of gh therapy patients regain their natural levels generally within the first week. So your natty production bounces back pretty quick, but don’t think that if you take an AM shot you’ll still get a natural PM pulse.

Now you have me curious. I would think that once GH or another hormone is introduced into the body then the body would shut down natural production of that hormone eventually. I've never heard that natural GH pulses stop for 4-6 hours then recover. Lol alot of it has to do with bro science too.