+ 13 IGF-1 Protocol (from Dave Palumbo)
IGF-1 PROTOCOL
UNOFFICIAL IGF-1 INSTRUCTIONS
(1) Storage of IGF-1 (prior to mixing)
Lyophilized (dry) IGF-1 is stable at room temperature for 3 weeks; however, it should be stored below -18 degrees Celsius (in the freezer section).
(2) Weight of IGF-1
1 milligram (mg) IGF-1 = 1000 micrograms (mcg) IGF-1
[Dry weight—before mixing]
(3) What to Mix the IGF-1 with
When reconstituting (adding water), It is important to remember that IGF-1 can get “stuck” in the grooves of the glass bottle it comes packaged in. While glass appears smooth to the naked eye, under a microscope, it is a convoluted landscape of grooves and hidden recesses.
By mixing the lyophilized IGF-1 with an “acid water” (e.g. 10mM HCL– very dilute hydrochloric acid), the IGF-1 molecules are efficiently detached from the glass and solubilized in the mixture. Any online “compounding” laboratory could mix up a 10mM HCL solution. Likewise, any intro chemistry student should be able to do the same.
If a reliable source of “acid water” cannot be located, mix your IGF-1 powder with bacteriostatic water—you’ll lose, at worst, 10% of the IGF-1 solution.
(4) Adding the Acid Water
For purposes of mathematical ease, I suggest mixing the dry 1mg (1000mcg) IGF-1 with 3mL (or 3cc) of the “acid water” mixture.
(5) Preservation of the IGF-1
Using a 1cc insulin syringe, draw 1cc out of the bottle that contains 3cc of the acid water/IGF-1 mixture. In a separate 1cc insulin syringe, draw up another 1cc of the solution. Freeze these two loaded insulin syringes. They will be utilized at a later date.
NOTE: Freezing can safely and effectively preserve IGF-1 (even after it’s been mixed).
(6) The Correct Dilution
To the remaining 1cc of IGF-1 that’s left in the glass bottle, add 2cc of bacteriostatic water. This will return the total volume back up to 3cc.
(7) The Mathematics
(a) The original concentration of the IGF-1 solution was 1mg (1000mcg) IGF-1 in 3cc of water.
(b) Each 1cc that we removed, then, contained approximately 333mcg per 1cc.
1000mcg / 3cc = 333mcg per 1cc
(c) The 1cc that was left in the bottle, then, also contains 333mcg of IGF-1.
(d) We added 2cc of bacteriostatic water to the bottle and brought the total volume back up to 3cc. The difference, now, is that we now have 333mcg in 3cc of liquid (instead of in 1cc)
(e) To determine how much IGF-1 is in 1cc, you must divide by 3
333mcg / 3cc = 111mcg per 1cc
(f) To determine how much IGF-1 is in .10cc (or 1/10th cc), we do the following:
111mcg / 10 = 11mcg per .10cc (or 10 unit marking on insulin syringe)
(8) Effective Dosages of IGF-1
Dosages in the range of 10-20mcg per day (taken 15-20 minutes after training) are quite effective for building and repairing muscle tissue. More importantly, these “moderate” dosages (by some people’s estimation) stimulate muscle growth yet escape rapid “downregulation” of the all important IGF-1 receptors. Without receptors to recognize the IGF-1, it doesn’t matter how much you inject.
As dosages climb to over 50mcg per day, receptor downgrade increases exponentially and, from what I’ve observed among bodybuilders, muscle gains come to a screeching halt.
Bodybuilders will have the most success with IGF-1 if they follow the protocol I outlined below. Remember, more isn’t always better!
IGF-1 PROTOCOL -- DOSAGE TOTALS
11mcg per day for 30 days (Cycle 1) -- 333mcg
2week off -- 0
11mcg per day for 30 days (Cycle 2)** -- 333mcg
2 weeks OFF -- 0
11mcg per day for 30 days (Cycle 3)** -- 333mcg
8 weeks OFF -- 0
Total # Weeks: 24 -- Total IGF-1: 1000mcg (1mg)
**The 2nd and 3rd cycles of IGF-1 treatment require that the two frozen 1cc insulin syringes be defrosted (only defrost one per cycle). Next, inject the defrosted solution into an empty bottle. Further dilute with 2cc bacteriostatic water. When adding the 2cc of water, use the syringe that originally held the frozen IGF-1. This acts to wash the syringe and ensure that nothing has stuck to the inside of it.
OTHER NOTES:
1. IGF-1 does not need to be injected into the muscle trained. 30 seconds after you inject the IGF-1, it’s in the blood stream and out of the muscle you injected it into.
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Take it right after training and right before drinking your shake. IGF-1 acts like insulin and will push nutrients and supplements (creatine, etc) into the cells.
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To recap above, take 11 mcg every day = 0.1 cc
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Easiest is delt or lat, but it does not matter.
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On off days, take it in the morning with breakfast.
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Keep the vial so you can re-fill it from the frozen syringes.
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connoristinyIs this the best peptide for hyperplasia?
TricepatopsBro you do realize this post is 11 years old.
connoristinywhy is it still here then lol. the design of this forum is mad confusing
Good read mate. It works systematically, it needs to flow through the blood. Subq in the stomach has been shown to be most effective, however, subq delt or glut works as well. Also research showed that 30-50 mcg was most effective for bodybuilding, 10-20 was for simple therapeutic purposes. And it should be 30 days minimum off to allow the new receptor to desensitize, what I read in a recent study. On a side note, LR3 can be taken pre or pwo and lasts 72 hours so EOD or e3d protocol for that. Oh, and the molecular structure of "synthetic" IGF-1 is the same as your own body's production. Normally they make it by recombinant synthesis which is essentially cloning the DNA. But everyone can come to their own conclusions and what works best for them. Just some side Info, which I may be wrong or right just what I've commonly seen and read
thanks bro,
yes right...everyone can do their own conclusions...
I wouldn't touch IGF-1 unless it was for injury rehab personally.
It's not the same as the IGF you body produces or converts hGH into, complete waste of money IMO.
On another note I couldn't find 10mM HCL anywhere just gonna make my own I guess...
So there seems to be some confusion here... Does the dosing protocol above hold true for igf lr3 as well? Also IM or Sq injection?
this is igf-1 protocol.you can do the same with igf-1lr3...
Dave Palumbo said IGF-1 does not need to be injected into the muscle trained because 30 seconds after injection of IGF-1, it’s in the blood stream and out of the muscle you injected it into.
so you could do IM and SQ,but in my opinion IM is better because it's faster
Im goign to be running IGF LR3 at 50mcg every other day for 40 days total, injecting around 6 hours after workout so I allow my natural MGF to do its work before incorporating IGF. This is also 3 hours before and after GHRP/GHRH shots, so there is a 6 hour gap between my last 2 PEP pins.
Heard good things about EOD injectinos and stopping the receptors from being over saturated. We will se ehow it goes.
BigBmajI used to love IGF - 1. I make very quick gains with it, like 10 lbs in two weeks and the pumps are amazing. But when I discontinue I loose everything and some. I've never kept one pound from cycle of IGF. My immune system takes a nose dive at the end of each run as well, I almost always get sick. Maybe this is a coincidence.
I've read some great things about IGF and I've read some not such great things. Some people say that its only good for promoting cancer. And that all this stuff about hyperplasia is false.
I've run it alone, with insulin, with MGF, with CJC and GHRP, with insulin and (bad) growth and nothing made it any better. I think my pituitary must down regulate quickly with this stuff or something. I also tried IGF - des and I didn't like that any better.
I don't know what I'm doing wrong? Perhaps I should give it one more try with this very low dose protocol. I've been meaning to ask this. Thanks for the bump.
bro,it's very strange that you gain 10lbs in 2weeks...it's very short time..and i think that is impossible to grow 10lbs of real muscle..maybe an increase like this is due to water retention.
there are different variables that can determine this...
i've also tried igf-1, but i didn't have a gain in weight and no water retention...
BigBmajOh yeah most certainly water. But it looks nice actually. A very full look that I like. Not a real ugly watery bloat.
and once you stop it,do you lose everything?
BigBmajYup. And some.
bump
Hey guys I ran IGF-1 LR3 a month ago. I did it during the whole duration of my PCT. I must say, I did not lose ANYTHING from my almost 20 pound gain cycle.
IGF-1 LR3 has made my pct exciting and I normally hate clomid and pct but this time around I did great.
I Honestly continued to make gains even after my PCT!!! I look bigger now then I did on cycle. Has anyone noticed this? By the way I am also using GHRP-2 + Mod GRF 1-29 2x a day. I am always hungry and my appetite is very strong for not being on cycle.
IGF-1 LR3 is good shit I wish I could stay on it forever!!!!
WithdrawlAfter my first run of IGF-1 LR3 I looked "different". I gained maybe 2 or 3 lbs but all my muscles look fuller and more round. It's hard to explain but yeah, I know what you mean about looking bigger after using it.
any recommendation of legit lr3 source? thanks
NO SOURCE DISCUSSIONS ON FORUM
skalpaive seen this protocol by palumbo before. my question is, do you guys find you get good results using only 11mcg per day? most of the threads on igf ive seen say to inject up to 100mcg per day. whos right?
WithdrawlI do believe 100mcg is WAY too much. I tried that dose at first and my gut got bigger. I think it's way overkill going that high. 50mcg is tops for me.
well Bro...he believes that the receptors may stop responding with a dose over 11mcg/day;obviously here we are considering real and good igf-1, not underdosed
that's because you are not using igf-1, you're using igf-1 lr3 which is a cheap shit peptide. go find real igf-1 from the pharmacy and run 10mcg of that and you will sure as hell see a difference.
skalpaso plain igf (not lr3 or des) is best? interesting, is the plain igf from the reputable peptide sources here sell Real igf?
No. They sell modifications of igf. Real igf is prescription only, similar to real gh.
skalpafuck, is it in the same price range as pharma GH?
You're a lucky fuck if you can even get it nowadays. Look up increlex. And if you somehow find it, hit me the fuck up. I coudnt even get you a ballpark price on it. And typically I can get a price on ANYTHING
skalpaill look more into it. my doc said he wouldnt think prescribing me gh would help with my height (even though i obviously had other plans for it hehe) but its too expensive anywayz and i rather try the cjc/ghrp combo instead. but ill have to ask if he could prescribe me igf.
Getting scripted igf is even harder than getting a script for gh.
skalpafuck, cant catch a break haha well out of the igf varients that are available what do you think is better, des or lr3? i was leaning more towards des because it will have more site specific growth. what do u think?
I think that I have the absolute best private peptide source and he doesn't sell igf for a reason. Because its not real. Get mod grf and ghrp2 run 100mcg each 3x a day and you'll be much better off.
skalpaive seen alot of happy people that get results with the lr3 and des. especially for keeping gains during pct. if they arent igf varients then what are they cus its not just bac water these guys r shooting
Hey, I'll let them take what they want while I stick to what I know works. And Dave wasn't talking about lr3 in his original post this is old.
I tell ya bro...that was awesome that whole take 2 ccs out and fill 2cc of Bac back in confused me untill i read this and it spelled it out step by step with math which was awesome thanks bro it helped alot
Thanks for sharing this
Great info bro, im also looking to IFG-1 use
+1
IFG-1
What does all this tell us?
It tells us that we should use IGF-1 to make more muscle cells. It's the only thing that can give it to us and more cells is more growth, which is our goal.
What does this tell us?
The localized effects are the best. Long R3 IGF-1 can float around your body and attach to anything that has IGF-1 receptors. The intestines is the place that has the MOST IGF-1 receptors and it also happens to have lots of blood flow. Injecting large amounts of Long R3 ENSURES that you are growing your intestines. Remember, more cells doesn't equal more size right away. Wait a bit, and see them grow.
What does this mean?
It means that if you are injecting upwards of 50mcg of IGF-1 you are growing your intestines. Yes you are also growing muscle and you may be getting leaner in the process. Your waistline looks trimmer. Nice. A few months down the line, your new intestinal cells will be of their full adult size and you will have acquired the perma-bloat look. Guaranteed. Maybe not Coleman-size perma-gut, but SOME perma-gut and it will keep growing. Guaranteed. Just as your new muscle cells can keep growing and growing IF you pin IGF-1 in a way to maximize new muscle cell creation.
HOW?
Heavy resistance exercise strongly upregulates the IGF-1 receptors on the stressed muscle. That means that after your workout, the muscles you trained are at their BEST STATE for receiving IGF-1 and growing many new cells. That's when you pin. This upregulation of IGF-1 receptor during exercise is short-lived. The science is not readily available so I am unable to quote a paper, but within 60 minutes of the last set, the receptors are back at baseline. This means, PIN IMMEDIATELY POSTWORKOUT and you will get your new muscle cells. PIN A LESSER AMOUNT and you will get only new MUSCLE cells out of your IGF-1. Pin more and you will grow other things, including stuff you wish you didn't grow.
What else?
All the talk about IGF-1's half-life is UTTER BULLSHIT. It is technicality without any real-world applicability. Yes rhIGF-1 has a "short half-life". But what does it mean? It means that it is either taken up by a cell receptor or bound up by a binding protein in short order. Does it mean that 20 minutes after the IGF-1 is pinned you should pin more because "blood levels are low"? Not by any means. Once it's activated a cell receptor, that's where it initiates a cellular response that will take about 72 hours to be complete and which will consume lots of energy. So the half-life of 20 minutes means NOTHING BECAUSE THE EFFECTS STILL LAST 72 HOURS ALL THE SAME.
What about Long R3 IGF-1?
Yes technically it has a longer half-life. Why? Because it either gets rapidly taken up by a cell receptor or... Just floats around. Until it can find a receptor or is destroyed by the immune system or some other metabolizing mechanism. BUT THIS MEANS NOTHING!!! Why does it mean nothing? BECAUSE once it attaches to a cell receptor, it initiates a cellular response that will take about 72 hours to be complete. THIS CELLULAR RESPONSE IS ALL THAT INTERESTS US. Not "blood levels", that's utter bullshit. As a matter of fact, the one thing YOU DO NOT WANT IS FOR BLOOD LEVELS OF IGF-1 TO BE ELEVATED. Because that means you are growing everywhere and this means first and foremost your guts. Sure it feels like it's working while you're on. Just you wait 9 months and see that you look like Craig Kovacs. Bravo, you now have the biggest intestines in the world.
Half-life means nothing. Localized vs systemic = bad argument. You want localized effects. Period. You get them by pinning immediately postworkout. Period. End of argument.
Extract source (http://forums.rxmuscle.com/showthread.php?59675-Very-good-I-found-on-IGF...!)
Also take a look at my forum post (http://www.eroids.com/forum/hgh-peptides/peptides/igtropin-igf-1-log-r3-...)
hey p great post you just cleared up all i was worried about,and if i may ask,do you have to worry about going hypo on the 11mcg dose vs.say 40 to 50mcgs.
Hi bro, i recommend you talk to mark86 (he's currently running slin and keeping me updated) - he's your best source for upto date knowledge
great bro =). +1. We can combine our information to create an excellent guide on IGF-1 protocol
Also have a look at (http://www.eroids.com/forum/hgh-peptides/peptides/beginners-guide-to-igf...)
There is lots of information out there and i'm very interested in its hyperplasia effects, but there is very little evidence resulting from tests on humans.
Here's some information I have came across
IGF-1 May Help Insulin Resistance
Human growth hormone exerts most of its effects through the powerful growth factor called IGF-1 (insulin-like growth factor #1).
As the name indicates IGF-1 (insulin-like growth factor-1) has properties similar to insulin and it has been shown to improve blood sugar profiles in type 2 diabetics. High doses of HGH have been shown to increase insulin resistance, but IGF-1 administration has actually normalized the insulin resistance in a group of volunteers.
Nelly Mauras and Bernard Beaufrere of the Nemours Children's Clinic in Jacksonville, Florida conducted a study where they looked at several areas. They studied the effect of IGF-1 on protein metabolism, IGF-1's ability to stop the protein-wasting caused by glucocorticosteroid drugs like prednisone, and the effect IGF-1 has on insulin and glucose metabolism. They divided the volunteers into three groups, one group received IGF-1 alone, one group received IGF-1 and prednisone, and one group received prednisone alone.
The study found that IGF-1 at 100 mcg per kilogram of body weight given twice daily enhanced the body's protein metabolism in the same way as human growth hormone did.
Like human growth hormone IGF-1 markedly decreased the protein breakdown in the volunteers who were taking prednisone but IGF-1 did not cause the diabetes-like effects of carbohydrate intolerance and insulin resistance as human growth hormone had done when given in combination with prednisone in an earlier study.
Instead, the test subjects who received IGF-1 and prednisone had normal glucose metabolism. The researchers saw this as remarkable because glucocorticoids are known to decrease insulin sensitivity and suppress the circulating insulin in the body. These researchers believe IGF-1 offers much promise in the treatment of protein catabolic states.
The Effects IGF-1 Has on Diabetes
Two 1997 double-blind clinical studies showed that recombinant IGF-1 injections can reduce the need for insulin in patients with insulin-dependent diabetes by up to 45%. One study involved 8 adults aged 24 - 49 and 43 children and teenagers aged 8 - 17.
While these trials lasted 19 days and 4 weeks and were short term trials, the fact that these test subjects saw such a drop in their insulin requirement and they had no serious side effects make IGF-1 a promising treatment of diabetes.
While in these short term studies IGF-1 therapy did not completely do away with the need for insulin, it did improve the control of blood sugar and so may help prevent the complications of diabetes.
very well, thanks Play for other informations. Now we have the ideas more clear, but remain many doubts and conflicting ideas bro