posted Sat, 04/18/2026 - 07:47
1401
+ 1 5iu+ in a single injection
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I remember hearing not to go above 4iu in a single injection.
Anyone else heard this before?
If you split it up, how much time do you need in between injections?
What’s the thought process behind this?
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There's really so much shit on the internet. One person thinks this, one person feels this way, one person reacted this way to this amount. Really the only way to know what is too much for YOU is to try different dosages and see. Everyone is different. While I think most(not all) but most people would recommend not going above 10ius a day that's not everyone. But for me personally that's too much. 6-8iu is my sweet spot and I usually do 4 in the AM and 2 at night or 4 and 4 or 6 and 2 but if I have other plans that will Interfere I take all 6 when I get up I just like the split and the night time bump helps me sleep and helps a ton with recovery. But like I said everyone is different brotha. Just run whatever works best for you, because you'll have 9000 different answers from 9000 different people for the most part when it comes to dosages. It's very much varied by person to person because our bodies all process things so differently. I'd start lower and go up until you either feel sides or don't think you're seeing any more improvement or even when your wallet or wife starts to tell you that you're taking too much growth cause it's expensive lol and then find your sweet spot going down from that.
Bro there’s a lot of half-truths mixed with bro science when it comes to GH… still a lot of gray areas to be honest. Some of these “rules” get repeated so much people start taking them as facts lol
There isn’t a real “hard cap” like people say with 5 IU max the liver can absorb … that’s not how physiology works. What actually happens is more like diminishing returns on IGF-1. GH pulses ->> liver converts part of it to IGF-1, but that response doesn’t keep going up linearly forever. At some point it just flattens.
That said, it doesn’t mean the extra GH is wasted. Like you our bro mentioned (and that great study that SeeOhShow shared with us points to), lipolysis keeps increasing with higher peaks, so bigger bolus doses means more fat mobilization. That’s why some guys prefer single larger shots when cutting.
From experience and what I’ve seen in real world + guys I trust:
1–2 IU HRT
* 2–5 IU … recovery, sleep, mild fat loss
* 5–8 IU … solid recomposition, better synergy with gear (you can use WAY less gear with GH)
* 8–12+ IU … now you’re pushing it, more noticeable changes but more sides too
Those big doses (8–12+ in one shot) … yeah, people do it. But usually they’re also:
Because the real limiter isn’t “liver max,” it’s insulin resistance over time.
As for splitting vs single shot:
People split not because they have to, but because:
Single big shot = bigger peak … better lipolysis
Split doses = more stable … easier on the body
So truth is in the middle IMHO:
No, your body doesn’t stop at 5 IU… but also more GH doesn’t keep giving you proportional IGF gains forever.
At the end of the day it’s not “what’s the max per shot,” it’s what dose actually gives you results without wrecking your glucose and daily function.
And yeah … we’re talking performance here, not medical GH use (different game entirely). Longevity might not be the best word… more like vitality and enhancement depending on how you run it.
Awesome… I just learned something
This ^^^ 100%. Great response brotha, I am with you on this.
Rock on. Thank you again Panda. I need to get stable at that 5iu level. I check glucose every morning. I’m hitting 108 consistently on 4-4.5iu. With that said, I was hitting about the same at 3iu. Vitality and enhancement Id say is a great way to phrase it.
I’m not sure if I’m toeing the line here or not. Someone help me here, please don’t shoot me if this is too taboo. Once we are moving from, say HRT, into the vitality/enhancement category, how much attention are you paying to Igf levels? Or even the performance enhancing category? And, if you can share, how are you using them?
'Steroidipedia' has spoken .....
Haha nah bro, far from that.
Just a meathead panda learning as I go… gotta work extra hard to make up for the natural stupidity
Unless you’re running like 15 units I think you’re good on one pin slut
God dammit I love being called a slut.
Nothing wrong with injecting 5iu
Had to ask. I know you like GH too! If you can point me to a good resource I’ll dive in and stop bugging yall
Do you get better or worse results with split dosing? What’s your preferred method? GH has significantly improved my quality of life. I want to see what other benefits it has.
Can one of you guys tell me what the difference between generic GH and say one of the pre loaded Pens? I would assume just quality but asking bc Ill be starting it at the beginning of next month. Suggestions?
Pretty sure the Pens are generally Pharmagrade HGH mate
I’d tell ya if I knew bro. Hopefully one of the cool guys will chime in for you.
Brother, I asked YOU because YOU are the coolest
kisses computer screen
I love you. Now where do we go from here?
10 iu before blood work
I can’t even make it past 3 iu without my right arm being incredibly numb 24/7. I wanna know how you guys are doing that. My entire ulnar nerve is just shot.
My hands go numb at 3iu.
I get the hand numbness but that’s nothing compared to how irritating the arm thing is and it kinda effects my grip.
The arm thing? Are you talking about when you put your arm down in just the right way and get the shocking vibration feeling? Sorry. Don’t know how else to explain it. Haha.
Nah it’s my entire ulnar nerve. And it’s like constant. I can feel it from my elbow all the way into my pinky and ring finger. This is a whole separate thing from my hands going numb. Ive had that and dealt with it, that seemed to only be like when I would up the dose too much my hands would go numb for like an hour or so here and there.
Damn that sounds rough. It’s wild how differently these compounds and peptides affect us individually.
I tried twice with it. First time I worked my way up 2 to 4iu over 7 months no problem. Cranked it to 4.2 the arm thing started and i put up with it for over a month then discontinued for 4/5 months. Tried again and that time i worked my way up 2-3iu over a 3 month period and it started happening before i even made it to 3 and i tried to tough it out but I was feeling like in my case, the cons were out weighing the pros. I would so much like to be able to utilize gh, but this shit is crazy.
I don’t want to suggest anything at all. I’m a novice with GH. Just speaking on my ignorant experience. When I first started, I struggled with shoulder pressure at 3iu. I backed it down until the pressure went away, then bumped it up again. No pressure that time. But the same pressure came again at 4. Same method got me to 4 with no pressure in the shoulders.
I’m gonna give it a go again down the road. But not until i can figure that out. I think it’s water retention related. But why just that specific nerve idk.
Mine was water retention related as well.
Hydration, good amount of potassium, high dose taurine, and GH with zero dimer
This is that "big boy" guy right?
Come on in. Jump on the bandwagon.
Oh don't get in your feels. It's 2026. Your free to love all the big boys your heart desires.
Nothin against it brotha.
Nah, a bolus dose before bed is fine. Instructions on serostim recommends one dose 18iu before bed. I typically use btwn 5-8iu before bed. Sleep like a champ
Old troll account. Basskiller.com research. Hgh is crap compared to food intake and need. Need meaning your blood test and how you use it.
Odd take.
So you ran bloods? Tested before and during?
Yes I’ll share with you in pm if you’d like to see.
5 i.u. is ghe max ghe liver can absorb
I had not heard this before today. Thank you for sharing
"Anyone else heard this before?"
Yes, multiple times from multiple people, both users and "PED gurus". Do I believe it? Not really.
"What’s the thought process behind this?"
I think there are two main schools of thought driving this:
1. IGF production may reach some sort of a cap based on a single bolus dose.
2. The half-life of hgh is less than 24 hours (somewhere around 7 - 19 hours depending on the source of your information) which could warrant more frequent injections.
Luckily, hgh is one of the few common PEDs with extensive ongoing research and medical use, providing us with a significant amount of literature. If we look at the medical application of hgh, it is prescribed to be utilized in a bolus manner.
Now, I could see the argument that the bolus dosing of prescribed hgh is in the interest of patient compliance not optimized results. Much like I personally feel better dosing Tirzepatide twice per week vs. Eli Lilly's once a week guideline. The counter argument to that would be that the pharmaceutical pen injectors used for hgh administration are extremely similar to those used for rapid acting insul*ns (which are obviously used by diabetics multiple times throughout the day), so are we really drawing the line for patient compliance at injecting multiple times per day or is the reason they don't split the dose because it does not provide tangible benefits?
Additionally, people tend to report more issues with FBG when administering hgh multiple times per day (I'll spare the reasoning surrounding this, but the evidence is out there). After a lot of research myself, I've come to the conclusion that bolus nightly doses are more practical for the average user and yield approximately the same results. For me, the possible minute benefits of splitting doses outweighs the potential side effects and logistical issues that may arise.
TLDR:
There is no right or wrong per se. I think you'll find the consensus generally is unless you're the next Mr. O, the most important thing is that you are taking your dose, whatever it may be. Timing and splitting doses is so far in the weeds that you probably have several other variables to optimize in training, nutrition, recovery, and PED use before if you split your doses or not becomes the limiting factor in your growth. The good news is there are tons of papers and studies on the medical use of hgh, as well as hours of videos free on YouTube to provide you with much more information than anyone on this forum ever could. If reading isn't your thing, I'd start with Paul Barnett or Think Big Bodybuilding on YouTube to get some more info on this.
Brother, first off, I can’t thank you enough for taking the time to share this information. You don’t have to look through this thread for long to find that there aren’t many people that actually seem interested in helping others. So I just want to let you know, I really appreciate you taking the time to share the knowledge. I wish I could give you more votes. Thank you, brother.
Lilly hgh was never doses 1x a week
I think you may have misread, I never said it was. I was talking about their instructions for the administration of Zepbound.
Take 5 IU before bed no issues
The igf response from the liver can only do so much, which is where you get that top out effect. The other benefits of HGH, such as the increased lipolysis, does not see such a cap. There’s studies showing that a large bolus dose has stronger lipolysis effects.
I've been doing 7.5 before bed lol
10IU here
We should just start doing 15 i.u. + and mutate here
Yall should really research dosing. Your b I dy can't use large doses like that....