posted Thu, 04/09/2026 - 03:54
489
Mast and Prov always give low e2 symptoms!?
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Trying to figure out why everytime i try to run mast or proviron (separate times not stacked!) I get low e2 symptoms within a few days. I’ve tried 1:1/2:1/3:1/4:1 ratios and nothing seems to work.
25mg prov makes me feel like shit.
20mg mast prop makes me feel like shit.
Symptoms include pissing non stop, moody, achy joints, super dry muscles , low energy and little to no libido.
Shbg is usually 10-20
Running US Roids - cyp 250
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Update
switched test sources and now I have no problems!
Glad you figured it out. Sad it happened to you :( I ended up tossing my 4 vials of test from that source.
Brother, not necessarily that Mast/Proviron always crash E2, but in your case it definitely looks like you’re functionally lowering estrogen too much.
Both Mast and Proviron are DHT derivatives, and they don’t aromatize … plus they can bind to SHBG and displace testosterone, which increases free androgens… but at the same time can reduce effective estrogen signaling. On top of that, they can have a mild anti-estrogenic effect at the receptor level.
Now add your SHBG at 10–20 that’s already on the low side.
Low SHBG means more free hormones floating around = more fluctuation and easier to crash E2 symptoms fast.
Your symptoms are textbook low E2:
Dry joints, frequent urination, flat mood w/ low energy, libido issues (people forget low E2 kills libido too, not just high)
So yeah, it’s probably not the compounds themselves being “bad” … it’s the context (low SHBG + dose + ratio).
Also…how much test are you running with it? That matters a lot
If test isn’t high enough to support aromatization, adding Mast/Proviron on top can just push you into low E2 territory real quick.
If I were you, I’d look at…
Slightly higher test base
Lower dose of Mast/Proviron (or even drop one)
Stop chasing ratios and focus on how your body responds, cause everyone reacts differently…
Some guys with low SHBG just don’t tolerate DHTs well at all … or need very small doses.
Just my opinion based on what you’re describing.
Appreciate the info!
When I wrote mast/proviron I meant mast or prov. I’m not running both at the same time but when I try either I get the same low e2 effects.
I’ve tried them both with trt dosing, 350 test and even 500 test weekly. Same result
So either I don’t tolerate them due to my low shbg, I need to up my test base or the test I was running was underdosed.
How much test are you running with it? Proviron should increase e2 by dropping shbg if total test remains the same. Mast doesn’t function as an ai but likely more like a serm. If test is getting suppressed then that could be the issue but if you’re running a test base that shouldn’t be a problem.
Maybe the mast serm effects are blocking ERs in the brain but I haven’t seen this effect before to a significant extent. Try pulling bloods while you have these low e2 symptoms to confirm it’s actually low e2.
That's a bummer that stack would have me feeling amazing calm confident and ready to blow out all the backs. I would think your free test would be higher as well
That’s weird. Mast and Proviron crank libido up for most including me. Also give me a nice “feel good” feeling. But everyone is different.
For me, my mental well being is all about DHT versus estrogen balance. Mast and proviron are extremely androgenic, so more e2 may be needed to balance it out. My lover @Aggieguy gave a good recommendation to adding HCG in, or just upping the test
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I'm guessing you don't handle short esters very well yet. I bet if you pin 20mg Mast Enan you will be gtg. Some new users just don't tolerate short esters very well, takes time. They hit hard at first and give the sides you've mentioned. Sides do go away though, just ride it out.
Why is your testosterone so low if you are taking mast and proviron? Are you trying to take those on TRT dose? That is your issue up that damn testosterone.
Being on TRT dose is basically normal testosterone levels so therefore normal estrogen levels then you add in mast and proviron and wonder why that estrogen is crashing? Your bloodwork is telling me it's not crashed. Raloxifene can help raise sbhg and it probably would not hurt to take some. It will not affect your overall E2 levels.
The real issue is you need more testosterone when taking other compounds or dont use them and just stay on Testosterone only.
For your Libido, get some HCG, take 500 iu twice a week.
I probably shouldn’t have included those bloods. They are just my most current draw but I’m not using mast or proviron currently.
Just saying that at any time even on my last blast with 700 test weekly I couldn’t handle mast prop dosed at 20mg ed. At that time I was using cyp250 from us roids - batch cp1101 so maybe it was underdosed….
You know what date you purchased that cyp250? There’s a couple guys reporting the white top ones from August and October ‘25 had them below their normal levels. I’m sitting on 4 vials from September I am scared to run because of it.
8/25/25 so roughly the same time
Underdosed test could be a real possibility then. Both users I mentioned had subpar bloodwork off of it. I’m just going to stash my 4 vials and use another sources I have. Will probably end up tossing them.
I was looking at his test levels he sent me and yes I believe his Test was bunk or way under dosed
More evidence for me to toss my vials, sigh :( not worth the risk when I’ve got plenty others waiting to be used. Just gonna chalk it up as a loss.
Its all good man I lost a shit ton as well test and dhb
That's probably your culprit (shbg)
Alright, so how would I actually raise SHBG? Run a proper trt and let things normalize? And since mast and proviron crush SHBG, what level should I aim for before trying again?
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