+ 3 Steroid Studies In Sedentary Men Are Not Relative To Bodybuilders
Recently someone posted a study of Anadrol use in sedentary men with anemia. Anadrol has been used for years for Hemodialysis patients to boost red blood cell count.
However, as with the original studies on steroids done on sedentary men the results are predicable and totally irrelevant to active bodybuilders.
Infusing sedentary people with toxic AAS will bring about very predictable changes for the worse in this study group. Simply put, the drugs remain in the persons system for long periods of time as they are not metabolized and bring about drastic blood marker changes such as Liver, kidney, cholesterol etc.
However, these same substances in higher doses used by active athletes will bring about changes, not nearly to the same degree, and are usually manageable. As athletes we metabolize the drugs much more rapidly and they leave our bodies much quicker.
So, this is not a FREE pass on AAS use without warning! Use them cautiously and monitor your blood panels religiously and make sure you are keeping things under control. The good news is with careful use and monitoring you can achieve great results while guarding your health!
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Let's see some research to backup your statements.
I thought the same we are all humans after all
I think no matter what studies we read common sense should prevail every time!
Use not abuse
And everything in moderation.......this goes for every thing in life
Oscar Wilde: “Everything in moderation, including anadrol”
Lol!!!!
Yes be sure to limit you anadrol to 100mg a day ;)
Last time I ran it I had a fucking nose bleed and felt like an elephant was stood on my head
The absolute worst has to be Eddie halls eyeball bursting out of its socket during his deadlifts due to blood pressure - He then pushed it back in with his fingers. If that isn't cringe worthy I don't know what is, bloody animal.
Link?
He talks about it all in the film about his life - Eddie Hall Strongman....
This is simply untrue. Anything that shows what happens at a Xna level where protein is an output is relevant to bodybuilders. Simply put any substance that increases protein balance in the body, is relevant and any study of it is informational and certainly not totally irrelevant.
Incorrect. The drug was delivered orally and not infused. Title: Effect of Oral Anabolic Steroid on Muscle Strength and Muscle Growth in Hemodialysis Patients
Too simplistic a view of it and in reality, wrong. You think active athletes cannot develop health issues and suffer from organ failure? What about all the other supplements they take too... you think perhaps a combo of compounds might make any study citing organ issues as highly relevant?
Bodybuilder with organ failure... shall we load her with anadrol???: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076034
But what about you personally John? You're no spring chicken (sure neither am I). What about the aging AAS user? Are they at an increased risk, if there is a naturally occuring decline in function of the aging person's organs? Add a somewhat toxic compound such as anadrol and then other supplements and ancilliaries that will tax the liver.... is that smart or is the study again totally irrelevant for you and I?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693148
I think not.
Science is science, data is evidence, relevance is subjective to a degree to each individual and their situation, but studies like this are always a tool in the belt.
+1 Well said - I just went for the bullshit button - I'm getting lazy.
+2
The AAS user is at increased risk especially the aging ones I agree which is why i say motor blood panels frequently. Yes the Drol was oral.
I gave you a +1 for advising religious observation of blood panels. That's some of the best advice any of us could follow.
It still passes through your liver
passes through much more rapidly!
I'm the guy who posted the study on oxymetholone. You truly believe studies on non-athletes using AAS are totally irrelevant to active bodybuilders? I don't mind a disagreement, mind you, I am just trying to pick your brain a little more. You stated that it is easier for a bodybuilder to recover from usage of an AAS like oxymetholone; however, I never implied that returning to baseline post-experiment was difficult for the men who participated in the study I cited -- because it wasn't. Their liver values returned to normal, their cholesterol was being brought back on the right track, etc. The only thing that varied was the drastic hit their HPTA must have taken, as Makwa pointed out, as a result of consuming the drug for a total of 6 months. Their total testosterone levels were all but obliterated... I think 95% below baseline.
I cited the experiment, which is fairly new, because I wanted to show people AAS use is fairly safe if being monitored by a doctor. That is not to say sides will not be present, but they will be much more manageable and will not linger long after cessation of use. Apart from that, simply considering how new the study is, I thought it would be interesting just to post it. Maybe others can get something out of the study that I personally did not. I'd hardly call that irrelevant.
Its not irrelevant. The main thing oner needs to understand is the difference at the rate these compounds are processed by someone laying in a bed versus someone in a gym doing cardio, heavy lifting while sweating and drinking tons of fluids.
To the contrary, hepatic elimination is not accelerated by exercise and, in some cases, might even induce diminished elimination. Moreover, rigorous exercise is known to promote stable plasma levels, and so in addition to oral AAS, exercise could potentially maximize absorption of IM injections of AAS.
Exercise induced inflammation? +'s for thoughts
According to a different article I linked on this post, exercise increases plasma protein and plasma volume. The best I can figure is that that explanation points, perhaps, to some sort of diffusion into the body's cells as a result. It's almost as if increasing plasma volume simultaneously increases the absorption of the drug within the body, or at the very least its bio-availability. That's my generic answer.
I think there must be some other mechanism to explain for it... Something I'll likely only be able to speculate when it does hit me.
Edit: My response still doesn't account for the potential of diminished elimination of AAS in athletes. There must be some sort of increase in binding affinity of some molecule, on some level, but I am hesitant to say with any degree of certainty. Moreover, this would be confounding because of our knowledge of active half-lives of AAS. I don't have the answer, and I wish I could articulate this through the point of more insight. Unfortunately, I just don't know.
Re-edit: Then again, if increased plasma volume attributed to exercise does somehow create an environment more conducive to diffusion, perhaps that would also explain the potential for increased sides. If my body is able to optimally absorb a substance, and hold onto it, wouldn't the positives of that optimal (increased) absorption come also with an increase in negatives?
Rustyhooker+2
Exercise will maximize absorption because when the body is pushed to its limits in natural terms, it learned to use every lil natural nutrition, hormone, oxygen etc to its fullest.
Its been proven time after time that the hardcore trained body will react greater to even the smallest steroidal/hormonal signals. Hormones are amplifiers to the whole given the above is in action and if proper fuels are applied (foods).
The crappy part and part that you and the OP are debating is the sedentary vs trained. Steroids are signals and therefore work on both instances. The degrees of sucess are greatly skewed but nonetheless, measurable. Its not fully appreciated by the atheletes because we spend decades perfecting out gyms and diets. But for proof in steroids and sedentary life, one has to look only as far as TRT patients.
Patients that greatly need TRT as a normal everyday human suffer from lethargy, foggy brain, fat gain, lack of drive for life and sexual intercourse. Most of the guys hitting trt as needed moved from sedentary life and towards a more active life simply because natures fires were lit. There more daily trt folks out there than juicers.
Health wise i can agree that the sedentary person would be less healthy in approach. Trt folks are documented as having heart attacks in the old, sedentary ages. But the comparison has to address the abuse of steroids as well. Both ends of the spectrum.
On intake, use, and expulsion of steroids id side with the healthy athlete. A body thats more in tune with processing all the foods, wastes, etc. But these medications were intended for clinical doses so we cant shut our eyes to the compared doses we take. Thus, expanding our debates, literature and uses.
Im just glad to see these debates. So much can be learned here.
You wordy old ba$tard, you!! ;-) Great thoughts on TRT here +'s
RustyhookerPandoras box opening
Excellent observation! I didn't consider TRT patients when comparing the absorption rates of IM injections -- only that of sedentary people to bodybuilders. But could TRT patients fall into either of the respective categories -- sedentary or athletic -- supraphysiological dosages of AAS aside? Furthermore, the results gathered in the literature I cited may be dose dependent, something the researchers did not measure. This topic is truly all encompassing and, like you, I believe debates like these are conducive to a more comprehensive understanding of pharmacokinetics. I'd like to see more studies about this topic released in the future.
RustyhookerTrt in either group....certainly. But peek in from both angles and which one really stands out. You got average joe trt that simply wants to feel human. Not atheletic. Other side is us older guys who been lifting long before roids were mainstream.
This is fun! Could hit into so many angles.
We need to see a couple of well done studies to prove that one way or the other.
I may have jumped the gun a little bit. I remember reading scientific literature that supported my previous claim, but researchers (in the link provided below) are a little more cautious about making any definitive claims pertaining to exercise and its relationship to absorption and elimination rates of exogenous substances.
https://www.ncbi.nlm.nih.gov/pubmed/14620948
Incorrect, it passes through the liver the same if you lay on your ass all day or exercise. Side effects are always the same.