+ 9 Tamoxifen in general lowers prolactin eliminating the use of dopamine antagonists
What do you guys think about this -
One study implanted prolactin-secreting tumors into rats and found that tamoxifen actually decreased tumor size and lowered prolactin levels. [2] In fact, it did it better than the frontline drug bromocriptine.
What research we do have all seems to indicate the same thing: tamoxifen, in general, lowers prolactin
Both cabergoline and bromocriptine are notorious for rather harsh side effects. Tamoxifen would also have the nice advantage of often raising testosterone levels a little as well
Nevertheless, tamoxifen's effect on prolactin and related tumors is interesting, because in many men it would have a much better side effect profile.
https://www.ncbi.nlm.nih.gov/pubmed/6697292
http://www.peaktestosterone.com/Tamoxifen_Prolactin.aspx
https://www.ncbi.nlm.nih.gov/pubmed?cmd=Link&dbFrom=PubMed&from_uid=7158226
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Good stuff right therrrr, up thumb
backonroidsThanks for this mate.
Np bro I've got some nandro nolt here I'll probably play around with it and see what the bloods say
This is good stuff +
Haven't read the whole full text yet but it's dose dependent...tamoxin was dosed at 900micrograms per kilogram...so .9miligrams per kilogram of body weight. That means a 200lb male(90.9kg) would be dosed at a little over 80mg a day. If you are looking st safer prolactin control I don't think anything gets better than b6 doses at 200mg 2x day
In one study yes but that doesn't mean the doses would HAVE to be dosed so high or weight dependant plus we are talking prolactin secreting adenomas (These pituitary tumors (also called adenomas) secrete excessive amounts of prolactin) compared to slightly elevated prolactin levels from deca or tren so in all actuality the doses likely wouldn't need to be very high at all
In this study it says :
"In the present study the combination of tamoxifen and bromocriptine was tried for the suppression of prolactin in prolactin secreting adenomas which were resistant to suppression with bromoergocriptine alone
10 women under treatment with 2.5-10 mg of parlodel (bromocriptine) for pituitary tumours of various sizes were additionally treated with tamoxifen 10-20 mg"
The results lead to the conclusion that tamoxifen is capable of improving the suppression of prolactin or render the adenomas suppressible in a large number of cases.
There's multiple studies on it..
https://www.ncbi.nlm.nih.gov/pubmed/6924910
Comparative study bt that and bromo meaning to be as effective it is dose dependent
There is evidence to support reduction but the more plausible explanation is that e2 stimulates prolactin
100% correct
E management is where it is at
Can't argue with that I've always heard if you control estro you control prolactin and it makes sense
I like where you are headed in just saying I'm not sure if it's safe at the prolonged doses st that level
I know Nolva can do damage to the liver but everything I read said it was prolonged use (1-2 years ) that causes that and that dopamine antagonists are much worse in terms of sides and effects on health... pick your poison I suppose LoL
Thats what I was saying, best option aside from caber.
I've been researching using b6 just dose info has varied quite a bit, I run caber but would like to give this a shot I think it's the better option for longevity n all.
Good info thanks
hmm interesting... agree with a few of the things already said... definitely would have to experiment & see what bloods show.... could possibly save quite a few dollars here and there if it did show good results. have heard of this a few times for sure!.. interesting though may need to experiment a bit
X2 and I can't remember where I seen it on here but one member had shared some information on just how bad dopamine antagonists can be for you I'll see if I can dig it up or if They read this hopefully they will share ..
What you're probably referring to is the discontinuance of caber for the treatment of parkinsons disease because of the link between high dosages, like they would take > 3mg a day, and valvular heart disease. I don't know of anyone that takes dosages that high to control their prolactin unless their caber is bunk; which in that case there wouldn't be any concern lol
here are some links to a couple studies about it
this one is about the connection of valvular heart disease and caber
this study looked at long term use of caber and valvular heart disease and didn't find a connection
×2
Yeh about really bad heart problems ECT..... I remember that one
unreal89I love cabser though
LoL
Interesting topic, I don't know I'd drop my caber for Nolva though.
I've heard of people dosing b6 vitamins to help control/lower prolactin which is what I'm literally researching more on now lol but I do agree caber can be harsh, so if YOU feel you've found something safer and more effective go for it, run bloods, and please keep us posted! +1 good read!
Yea I was going to say I'd base it entirely off bloods I mean it's worth a shot the sides plus the cost difference between caber and Nolva would justify giving it a go imo ... the only thing is I've read never run Nolva with a 19 nor but again i dont know how much of that is true or just bro science...
Interesting read either way.
I've had caber on hand but never actually had to use it running deca but my doses weren't very high either.
Yeah I've heard the same, but hey wasn't too long ago they didn't even have a post cycle n ai was extremely optional lol ALOT of info here n everywhere else on the web is bro science.
But I could care less if someone on here thought my way of running a cycle wasn't right as long as my blood work showed a healthy body n high test levels Ima keep it mother fucking moving!
I'd use the "standard bro science cycles, doses, etc" as a guideline until experience shows you another way of doing things, a safer more as you said cost effective way as well!
100%agree, I see a lot of advice on here that says u cant use this for a kick starter, or u need to use this for min 20 weeks, or this wont work unless u use 600mg/week yada, yada,yada. Broscience as u say--good guidelines but these are not hard and fast scientific rules. Do what works best for you first and foremost and bloodwork doesn't lie
1000% agree man
Very true bro always bloods to back it up bloods don't lie
Hahaha true that bro well said keep it mother fuckin movin
New info is always coming out and things are evolving all the time but old school exp trumps any study there is