+ 12 IGF1 Vs GH Serum
Examples of IGF1 Elevation from one SubQ Injection (Same Day)
CLINICAL STUDY (HGH Products)
Two randomized, double-blind, single-dose, three-way crossover studies were carried out in 36 young healthy volunteers each. Endogenous GH secretion was suppressed with a 25-h continuous i.v. infusion of octreotide (40 μg/h) starting 1 h before rhGH administration.
IGF1, IGFBP3, NEFA were used in determining Bioequivalence between two rHGH products known to be identical to ones own Growth Hormone. (Same Amino Acid Sequence)
(If two products are said to be bioequivalent it means that they would be expected to be, for all intents and purposes, the same.)
Injecting 10ius IM and waiting 3.5 hrs for the known "peak" was not used in this study nor was the GH Serum results used in determining Bioequivalence.
GH Serum levels depend on many factors and are inconsistent from test to test. These factors include injection timing, dosage, diet, current body levels of amino acid degrading enzyme responsible for HGH degradation, potential immune response, etc. For this reason you are unlikely to get the same growth hormone test result twice. GH Serum results cannot determine the quality or potency of HGH. This is a common misconception often mentioned on bodybuilding forums. HGH serum levels will not tell you "how strong" the growth hormone is.
GROWTH HORMONE, SERUM Test Examples from one "Kit" using the "GH Serum Protocol"
8.0 ng/mL
7.2 ng/mL
30.5 ng/mL
13.3 ng/mL
Example of Diminishing IGF1 from a GH Product(s)
GH Serum would not be able to determine
The therapeutic effects of GH are mediated by IGF1. IGF1-binding proteins (IGFBPs) play important regulatory roles in controlling the bioavailability and action of IGF1, and are regulated by various factors including GH. About 90% of IGF1 is bound to IGFBP3. Because rhGH preparations induce significant increases in IGF1, IGFBP3, and non-esterified fatty acid (NEFA) related to GH mechanism of action, these molecules are accepted as pharmacodynamic (PD) parameters for GH activity; however, the spurious relationship between serum IGF1 levels and growth response precludes the use of IGF1 as a surrogate marker for efficacy.
IGF1 as a surrogate marker is in reference for approved GH.
IGF1 test is not designed to test for the "purity" of the product being used.
Can anyone explain the significance of GH Serum Testing?
Should we be injecting an entire vial before an IGF1 test?
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Thank you for info razor
great bro thanks!!
I've always felt serum was pointless and tested for IGF1. Very good info
Thanks so much for sharing this much valued information brother! Great posts like these benifit the entire community! I am so challenged when it comes to science whereas you are gifted! Your consistent posts edify, enlighten and inform! Thanks for all you do HailRazor! +2
+1 this is a very good post! This goes to show also my belief that igf should be pulled only as the person normally runs it! Seems the 10 iu spike is kinda pointless if u want to c where our real igf numbers land.
Super detailed and interesting post my bro. Thank you.
This backs up a lot of the points I have made recently, and over the years about testing. G protocols.
For my opinion testing of bloods is a wild west crappie shoot, yet can yield basic results and details with testing.
I never see any reason to take more gh for a test... than u would use daily...
Anyone thinking about contacting a major pharmaceutical company using an alias?
I have dealt with Pfizer in the past while verifying cabaser2mg (upjohn)
And have received materials and legitimate answers from them, even while using a pseudonym
Treadintren (MOD) was in contact with Norditropin (I think). He shed some light on IGF1 elevation (plateau/saturation).
I've posted info about this before. It's hard to go "against the grain" of information posted on every BBing Forum. But, there is lots of misinformation unfortunately.
I like it brother. Should be linked all over the place for the guys pounding their chests over numbers......
Lots of 22gauge needles to da veins for this one TonyT.
Steveb.
Very interesting bro and I believe this post stands to change the way we view GH testing around here.
Whoa, I was told there would be no math.
Hail, I liked it better when you just told me what was good and what was crap.
AnonThat is epic.
It's like the great carsberg adverts would say we don't do GH tests but if we did they would probably be the best GH tests in the world.
bigwillyMan there's like 25 guys i can't wait to see come on this post and run there mouths. Lol
Serum is pretty pointless. I pulled a 66 on premixed omnitropes on 5ius shot Im 3.5hrs before. That's an insane number. So does thay mean I would get a 122 on 10ius lol? Doubt it. Even igf-1 is somewhat pointless I've had generics over 500 that did nothing for me. There's so much more to it then just elevated igf-1 and serum numbers.
Ok I'm new to this then how do you know other than running it for a few months?
bigwillyyou don't brother !!
that was protocol back in the day, run it for 6/8 weeks to know for sure. you see, it is not medically possible to know if gh is any good by running it for 8 days.
Apparently "with bloods" it is now..
bigwillyhahahahaha yea it seems that way
ZandaThanks for testing HR! Much appreciated. This is a great benefit to the community...
IMO GH Serum is like the horsepower on your new car. Guys out there posting these 20-30 ng/ml tests saying its the best hgh on the market etc etc. I look at IGF as the REAL WORLD results. What good is a high GH SERUM when your IGF is in the mid 200's after using the product for 8 weeks? It's like your bragging that your new ride is 575 HP, but your 0-60 time is 12.1 seconds and your top speed is 79 mph. GH Serum doenst mean Jack shit as far as I'm concerned. It might tell you that your gh isn't FAKE but it does NOT tell you the quality. This is JUSY MY OPINION feel free to disagree
Great analogy comparisions!! My 470hp 455tq (locked converter on the dyno) TA runs 11.3@109mph.
I'm blowing these 2010-15 550+hp stangs/vets/lsx every opportunity.
I believe it!! IGF gives you the benefits GH Serum gets people warm and fuzzy but means Jack.
rocketballzThanks for tesring man!
I'm not sure if I'm allowed to post here, but with HailRazor kind permission -
It's a common knowledge that any serum test (GH, IGF1) may give an indication for the clinical effect of the GH, but it's not an absolute barometer.
So far it's the best tool to be used for the regular consumer.
Of course a comprehensive chemical and biological assays are the accurate standard, like defined on USP.
Such tests me be arranged in the USA, though of course more expensive than a regular serum tests
Here is an example - https://www.eroids.com/pics/maldi-tof-mshplc-uv-vis-rhgh-results
I know this member has been researching and tested many other brands by these standards, you may ask him.
You may PM me after weekend and I think I'll have a list of labs in the USA that may offer such tests, if I fail I'll get in Europe
No permission needed Karl. The more info the better. This is more for the guys doing GH Serum tests alone and over analyzing the number.
Mands posted:
LabCorp GH Serum Testing for a "range" of GH Proteins (20K+/22K+)
A list of U.S. testing Labs for GH would be great. TY
Wow thanx for taking the time for this huge study thank you for your support, help ,effort, and contribution about HgH knowledge
+999999