posted Thu, 01/09/2014 - 03:07
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+ 3 Suicide inhibition and regeneration of aromatase enzyme
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I had a question... People will say that aromasin is the better ai because it is a suicide inihibitor, but then others will respond and say that it is essentially the same because you body produces more aromatase enzymes... My question is if you using adex, does your body still produce more aromatase enzymes, and if so, then wouldnt you end up with a substantially higher amount of enzyme when compared to an aromasin user? If not, then wouldnt adex be better because it holds your body from producing more enzymes and limits the amount of estrogen that your body will produce given an amount of test?
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https://thinksteroids.com/articles/antiestrogens-anti-aromatases-estroge...
Aromasin is not better. Aromatase enzymes get synthesized anyways. There's no such thing as permanent blocking of estrogen
less enzymes are synthesized on arimidex because it doesn't permanently bind therefore your body doesnt need to synthesize as much
AI dont create more aromatization, the hormones we put in our body do the conversion.
AnonFrom what I've learned the body's rate of aromatization is dependent on the state of the HPTA not the AI use. So for instance, you have patient A who is a non steroid user with a perfect balance in his HPTA. He has no disorders to his endocrine system no disorders to his HPTA. Therefore his rate of aromatization would be relatively low.
Then you have patient B who is a heavy steroid user. In particular he is using large doses of anabolic steroids which have high estrogen conversion rates.
Aromatase Inhibitors merely block this enzyme or permanently binds itself to it through hydroxylization. Neither mean that the steroid use stops aromatizing because it will continue to happen as long as there is active exogenous hormone in the body. Hence the need for homeostasis brother. The HPTA is under attack the entire time you're on cycle. It needs and wants homeostasis. The only way to counteract this attack is to fortify the defenses. Aromatase Inhibitors. They don't create more enzymes, in our particular case the steroids do that. The way you describe this would indicate that my dose of Aromasin would likely need to increase over time. If more enzyme were created from its use then eventually I would need a higher dose to counter sides. That has never ever been the case for me. My rate of aromatization is established. I've run some pretty crazy cycles and I know my dose of Aromasin works.
I would say neither Adex not Aromasin is particularly better than the other. I'd say until you've run both you won't know which works better for u. That's the key here. Which is metabolized by the body more efficiently and has less side effects. Since I haven't read anything that AIs are responsible for the creation of Aromatase enzymes I can only assume you might have this confused with an E2 rebound. That normally happens when someone discontinues Adex or Letro while there is still a lot of exogenous hormone available. Also when Adex and letro are discontinued the enzymes that they had been blocking are now free to attack the receptors. Aromasin because of its suicidal properties has much less instances of a rebound. But that doesn't make it better ultimately. It may not work with your body's chemistry. For some it crushes all E2 and hurts their gains. It's a personal choice brother.
"From what I've learned the body's rate of aromatization is dependent on the state of the HPTA not the AI use."
Aromatization Primarily is dependent on the amount of raw material available i.e. testosterone and the way a person's body personally aromatizes that compound. There are a lot of things affecting that process, such as high body fat, genetic predisposition, etc.
The HPTA does come into play But not as much as the amount of Testosterone. That is why regardless of who you are if you are taking supraphysiological levels of testosterone you must incorporate an AI. The dosages and protocols will vary from individual to individual but the fact remains that you will need some sort of AI to balance out the equation.
AnonAnd what my friend is the Testosterone doing to the HPTA while in our system???? It's basically fucking with the entire thing in cases of classic steroid cycles. Maybe not so much in the case of TRT guys who are dependent on exogenous test to have homeostasis of their axis. That's what I was trying to articulate. I was generalizing and after reading it I guess it is a bit too vague. But yes obviously the main culprit is exogenous hormones. Which in turn throws the homeostasis of our HPTA way out of whack.
I know what you are saying but I was trying to clarify it. Because testosterone will disrupt your HPTA but there are other compounds medically that can disrupt your HPTA That will not cause a spike in E2 due to conversion. So there is a distinct difference between the two. So even though the HPTA Is in the mix it is not the culprit.
Here is another example of a disrupted HPTA that will not lead to elevated E2. Primary hypogonadism, No testosterone, no elevated E2 from conversion (it could come from a different area like a hormone producing tumor but that's another subject matter).
Now that is some awesome, well written info right there. I also want to stress, as you did, that just because one ai seems better on paper doesn't mean that's the best one for you. Perhaps your body won't respond well to it or perhaps you will get ever side possible. Try both and as always I recommend to find the minimum effective dose that works for you and not a drop more.
x2 great posts
mh001Awesome. Thanks for clearing that up for me.
well said!!
As far as I know in its medical use for breast cancer it has the same mission, reduce strogen levels nd usually dose doesnt have to be increased. If u R asking for the reason the body doesnt produce more, that I dont know
Sirk1981I would like to know what the vets think also. Great question.