mh001's picture
mh001
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+ 3 Suicide inhibition and regeneration of aromatase enzyme

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I had a question... People will say that aromasin is the better ai because it is a suicide inihibitor, but then others will respond and say that it is essentially the same because you body produces more aromatase enzymes... My question is if you using adex, does your body still produce more aromatase enzymes, and if so, then wouldnt you end up with a substantially higher amount of enzyme when compared to an aromasin user? If not, then wouldnt adex be better because it holds your body from producing more enzymes and limits the amount of estrogen that your body will produce given an amount of test?

j223's picture

Aromasin is not better. Aromatase enzymes get synthesized anyways. There's no such thing as permanent blocking of estrogen

less enzymes are synthesized on arimidex because it doesn't permanently bind therefore your body doesnt need to synthesize as much

mwagner630's picture

AI dont create more aromatization, the hormones we put in our body do the conversion.

WhyNot's picture

"From what I've learned the body's rate of aromatization is dependent on the state of the HPTA not the AI use."

Aromatization Primarily is dependent on the amount of raw material available i.e. testosterone and the way a person's body personally aromatizes that compound. There are a lot of things affecting that process, such as high body fat, genetic predisposition, etc.

The HPTA does come into play But not as much as the amount of Testosterone. That is why regardless of who you are if you are taking supraphysiological levels of testosterone you must incorporate an AI. The dosages and protocols will vary from individual to individual but the fact remains that you will need some sort of AI to balance out the equation.

WhyNot's picture

I know what you are saying but I was trying to clarify it. Because testosterone will disrupt your HPTA but there are other compounds medically that can disrupt your HPTA That will not cause a spike in E2 due to conversion. So there is a distinct difference between the two. So even though the HPTA Is in the mix it is not the culprit.

Here is another example of a disrupted HPTA that will not lead to elevated E2. Primary hypogonadism, No testosterone, no elevated E2 from conversion (it could come from a different area like a hormone producing tumor but that's another subject matter).

iFit's picture

Now that is some awesome, well written info right there. I also want to stress, as you did, that just because one ai seems better on paper doesn't mean that's the best one for you. Perhaps your body won't respond well to it or perhaps you will get ever side possible. Try both and as always I recommend to find the minimum effective dose that works for you and not a drop more.

markymark's picture

x2 great posts

mwagner630's picture

well said!!

MB's picture

As far as I know in its medical use for breast cancer it has the same mission, reduce strogen levels nd usually dose doesnt have to be increased. If u R asking for the reason the body doesnt produce more, that I dont know

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