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+ 18 Clearing Your Receptors 101

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Clearing Receptors 101

A lot has been said in regards to clearing the receptors and I thought now would be a good time to delve into this subject and simplify things.

Basically, one must view the receptor sites as parking spaces.

Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger, fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the cook, who would in-turn make the food and the waitress would then bring the food to you and you would then begin eating which is the whole reason you came to the hamburger stand in the first place.

I think everyone can easily understand that. Which means everyone can easily understand all they need to know about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and explain what happens when you inject steroids

Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can place them they must first find a parking space.

Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the system because they previously only dealt with what your body naturally produced. However, there are lots of extra parking spaces that can be utilized and so the steroids park themselves into these spaces.

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of "DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the receptor spaces, if they are already taken up by old "dead cars" you are shit out of luck.....

This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors parking space.

This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in new muscle mass!

O.K. Trevor, I am with you so far, but what the f*** can I do about it?

The answer is ...PLENTY!

First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is "too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars" you will have sitting in the receptor parking spaces which means NO MORE GROWING!

Now with this in mind, how can we help get the cars out of there?

Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time in this situation which is why it is important to utilize short courses that will cause less disturbance in the system, less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up the spaces.

That being said, it should be noted that even short course will pile up "dead cars" after a while and you should give yourself an extended clean out of 2 months at least once a year.

But Trevor, isn't there anything I can do to help speed the process?

Once again the answer is yes!

You can help speed the process up dramatically by increasing your metabolic rate...Speeding up the metabolic rate is akin to hiring extra tow trucks to clear out all those "dead cars" that are occupying the receptor sites!

Have you ever know a person who was much, much fatter than you and yet ate half as much?

These poor bastards think they were given the genetic shaft and try every diet fad imaginable only to stay fat. Their problem no longer lies in their eating habits--which is ironic--; it lies in their metabolism, which basically was shut down due to the excess eating and lack of exercise that got them fat in the first place. Once you understand this, you can easily control your weight for the rest of your life. But what the f*** does this have to due with steroid receptor sites?

EVERYTHING!

The same thing I would prescribe someone whose metabolism has shut down due to obesity, is the same thing I would prescribe someone who's receptor sites are all clogged and is no longer making progress....INCREASE THE METABOLIC RATE!!

Below I will outline a few ways this can be achieved in the constraints of a 4 week Receptor Clearing Cycle follwing the completion of a Muscle Building Course using anabolics:

Diet: I suggest cutting back 300 calories below maintenance per day during a 4 week off time from your anabolic regime...I also suggest eating 6-8 small meals spread out from early morning to late at night. The higher the number of meals you eat, the more your body has to go to work and break down the food which causes the metabolic rate to increase.

Aerobics: Yet another tool in the battle to increase the metabolism, I would suggest low level aerobics 5 times per week 30 minutes per session.

Pharmacology: It is important that one does not have ANY anabolics that are active in the system during this time period.....make sure that you have had a good 4 weeks since your last shot of long acting compound before you embark on this 4 week receptor clearing cycle....otherwise you are wasting your fucking time! That being said, I would suggest the use of the following compounds to help accelerate the Receptor Clearing Process:

  1. D.N.P.-- Understand that this is a fucking vicious poison and a component in T.N.T., and I do not suggest it's use at all, but to be fair I must admit that NOTHING can raise the metabolic rate like D.N.P. can. Because this is well known, there are many people that will want to try it...This being the case, D.N.P. should only be used in the following manner during this course: 3 days on, 4 days off at a dose of 4mg per kilogram of bodyweight taken before bed----have plenty of towels around and a fan to keep you cool!

  2. Cytomel--T3 is another booster of metabolic rate which is why the fitness models live on this stuff...it keeps you engines running high and burns the fat right off....In this case, we are more concerned with the fact that it increases the metabolic rate. Suggested use is 75mcg -100mcg 5 days on 2 days off for the 4 week course

  • If you do not wish to use D.N.P.---which I think is the smarter approach as it is very dangerous.

There you have it...a brief simple lesson on your receptors and how you might go about keeping them free and clear so you can continue to Grow, Grow, Grow and they begin to go to work.

SOURCE:

Smith, T. (2010, February 04). Steroid Receptor Clearing. Retrieved January 17, 2012, from isteroids: http://www.isteroids.com/steroids/Steroid%20Receptor%20Clearing.html

michiganpokerguy's picture

this was very interesting while reading this on my lunch break sitting on the pot. gotta love it!

hos1981's picture

I was thinking about using a small dose of S4 during PCT and as a bridge to help keep gains. After reading this post I'm having second thoughts. Is clearing your receptors a must? Does S4 have a strong binding property to receptors? I've also herd mixed thoughts on how suppressive S4 is.

ErieToPitt's picture

I'm a big fan of SARMs, but I would recommend using Ostarine if you're going to during PCT and not S4. Save the S4 for after your PCT because it will suppress and during PCT you're trying to get your levels back up.

S4 combined with Ostarine, and Clen make for a great cutting cycle.

Jayboogie's picture

Cheers bro! Interesting read.

NuclearMess's picture

Good shit bro

Dangerdave88's picture

Great stuff man. Thank you for sharing.

Axecution's picture

rHGH also as the same effect of increases metabolic rate (however through a different biologic pathway). As a mitogen it promotes cell division (mitosis). This in turn elevates metabolic rate. Using it on cycle can clear up receptor sites. Another method is high affinity antagonists like 3a-Androstane (a metabolite of DHT)

Warmachine's picture

Honestly will someone please "check " this site. Says its domestic but a ton of spelling is wrong and it looks really new...

VinnyWinny's picture

Interesting read..

counerstrike1's picture

Quick question. Would it benefit to run cytomel-T3 towards the end of a test-E only bulking cycle when gains are starting to slow to a hault? Or is the metabolism already cranked up to its max?

BeastFromTheEast666's picture

This information was very useful , I love coming here and learning new things. Thank you !

SL's picture

But Trevor lol

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Xrated's picture

Good post thx for the info!

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ballymena23's picture

im not an expert by any means but i thought thats what gh was for, cell division which would technically mean more new cells with clean receptors?
please correct me if my theory is wrong

enigmatic707's picture

When it comes to gh- I'm no exper either but if I am correct it's not actually cell division that occurred but satellite cell activation... Which in of itself is highly complicated.

enigmatic707's picture

This write up is a good introduction to the concept of the AR and binding of hormones to the AR-

BUT.. there is a huge amount of complexity that was glossed over or simply not stated. Hormones don't stay "parked" in the AR. In fact they cycle out back into the bloodstream quite quickly in forms of metabolites or intact still.

The main reason that hormones start to yield diminishing results is due to the down regulation of the AR- this is not directly influenced by the AR agonist, nor the amount of transcription of the target genes. The true mechanism is some what still lost on us. But the signaling pathways have been reveled.

There are two primary signaling components in the mediation of the AR- t Akt and nuclear factor nB
(NF-nB) regulate the AR signaling pathway by phosphorylation of AR or transcriptional regulation of AR

basically, we still dont fully understand the methods by the cellular activity corresponds to the regulation of the transcription through both of these pathways- if we did prostate cancer would be almost completely gone.

**Down-regulation of Androgen Receptor by 3,3¶-Diindolylmethane
Contributes to Inhibition of Cell Proliferation and Induction of
Apoptosis in Both Hormone-Sensitive LNCaP and
Insensitive C4-2B Prostate Cancer Cells

eastcoastmuscle's picture

what about guys on TRT, i gues there recepters are never cleaned out they are always flooded?

Makwa's picture

When on TRT you are taking just the amount needed to bring your test back into the normal range. The goal is to not have more test than you would naturally have. So in essence, you are just filling up the "parking spaces" with the test that would have been there naturally and not using up any additional parking spaces.

jpal's picture

was wondering the same thing

highgear's picture

thanks so much, very helpful!!! Great post!!!

Bigniz77's picture

Awesome thread!! I've always thought short cycles and esters were better to keep receptors open and keep more constant results but never had proof from something credible to go back on. I'm definitely going to try this cleansing cycle.ya I've stayed on for months on end before and saw great results but you gotta switch things up to keep making your body go "what the hell is going on" and to keep growing!!

highgear's picture

thx buddy great post very helpful

Mars's picture

good write up, right in line with my own schooling. imo nothing can replace a good diet that's rich in variety of foods.

burpee55's picture

I was aware of the problem but wasn't aware that there was anything you could do about it.. very helpful and thanks.

nikko85's picture

Very well written and informative post! Thank you for taking the time to write this up.

DmCastro's picture

This was extremely helpful I have to let my receptors rest then to grow more i always thought the more u pin up the bigger u got obviously with training and nutrition aswell, good thing I've been of for almost two months can't wait to pin up again I swear I have like dreams about it lol

Red20s's picture

I've tested this theory my self before "increasing metabolic rate" to clean your self of anything previously taken and I couldn't agree more that this actually does work. Just like with recreational drugs once you take to much or to often you do not feel them anymore. With HIIT sessions of cardio and protein meals after wards you always manage to clean up your system. Going back to basics like grandma used to say if you got a fever wait and sweat it out, same for anabolics; sweat them out thus increasing metabolic rate. I also believe user #Knives423 is a little ignorant for disagreeing with a statement without scientific backup.

knives423's picture

This is straight up bullshit bro science. Isteroids is not a valid scientific source. Testosterone does not turn into "dead cars". There is so much bullshit in this post it is not even funny. The parking space metaphor is valid to an extent in which if you inject way too much testosterone at a certain point every receptor will be occupied and you wont get any additional effects, That is it. Testosterone is used up during workouts by the muscle building process, it is also metabolized by your liver in a time frame depending on the ester injected (longest is 2 weeks for test cyp). You do not need to "clear out your receptor" for fucks sake just typing that phrase makes me feel stupid.

The reason that people cycle and take time off in between cycles is so that they don't do permanent damage to their testicles and other glands used in regulating the amount of natural testosterone your body produces. If you stay on cycle for months to years on end like pro body builders do your body will lose the ability to produce natural testosterone and you will be on TRT for life. No amount of DNP or cytomel will ever be able to fix this.

Again i can not stress how utterly stupid this post and the article it links to is so i will write it in capital letters- THIS POST AND SOURCE ARTICLE IS COMPLETE AND UTTER BULLSHIT.

btwha123's picture

i agree in no way do androgen receptors work that way. they actually up regulate in the presence of androgens. i never come off and experiment with it throughout the years and i only get bigger as time goes on. i do believe the liver metabolizes the ester more quickly as the body gets use to it, so switching it up once in awile works.

Sumatra_Triangle's picture

Very interesting stuff. I really appreciate your time!

hugetom's picture

Good post! Must be read by everyone who likes doing many cycles per year.

shedph's picture

wouldnt you lose some mass/muscle by dropping cals below mantenance for the 4 weeks off,i know you drop cals a bit but thought it was always maintenance or above to keep gains?

deathdodger's picture

This is very useful thank you.

spartacus91's picture

great info iv read this twice to make sure i got everything i can from the posts.as kevdawg said you should write a book lol

Zscd9's picture

Great read! Well done

Tiltedview's picture

Well written.....great post

ANIMALHOUSE's picture

Thanks for the info!

xroids's picture

nice post i love it.

kevdawg's picture

damn you should write a book... good info bro

mrgut28's picture

I don't know if I buy into receptor saturation or not all I know is as of now I am not responding the way I know I can.

I have been on probably better than 15 weeks with 3 weeks off in the middle. I have been on 500mg test and 700mg Eq weekly and before I Took a short break due to a minor surgery I was gaining as normal but now holy shit I have seriously plateaued. I lost my appetite, got weaker and noticed I have even gotten fatter :-( WTF! . I've decided to take 3 months off now and try again in august...

This is the first time in 10+ years I've ever experienced a decrease while on gear... sad. Btw I been using the same stuff my whole cycle so I know it isn't the product. ???

msus504's picture

If you train hard, give yourself the right nutrients, and the right amount of gear its going to put on muscle and use what your putting into it and adapt to what your doing to your body (human bodies are amazing adaptive machines!), common sense! otherwise aas would never work in the first place because our receptors would of been filled years back with our own natural stuff imo, i dont buy into the receptor stuff either and would like to see med data, it is interesting topic i would like to see though...

subs33's picture

You mentioned that to me in a PM a while ago. You would have more experiance then I do with blast and cruise and could contribite a little more facts against the clearing receptors theory.

The post is a very informative post, but in my opinion its just Broscience. I agree, I would also like to read into this theory and base my decision on some more creditable resources.

Here is my Bro science theory..Any type of medication we take our body is goin to build a tolerance to and more medication is goin to be needed to reach that point, as when we first took the specific medication. If we were to drop the dosage of that same medication and suffer withdrawal/crash or any other reaction to dropping the dosage. Our body will adapt to the drop, once the body adapts to the reduced dosage and we increase the dosage. I feel our body will have the same reaction to the increased dosage as it did the first time. Maybe, not to the full extect but really close. I have experianced this with several different medications(non-aas) and Im currently cruising for the first time using only 300-200mg of test a week. I plan on uping to 700-800mg in June. If I dont get any gains with the inceased test and proper diet. Then I will Believe in this Receptor Theory.

Sorry about the long Reply msus504. Most of it was for a read to the general.

Also to the OP..I did see you gave credit to the source. I have read that post on several different forums and each forum puts thier own twist on the bro science..I see now the post has added taking all kinds of compounds to help clear receptors...LMAO..Common now, what happened to the basics EAT, EAT, EAT and grow.

msus504's picture

yes absolutley, that is exactly how i feel on this, i actually read somewhere i beleive it was a dave P post with him discussing how any more than 2 grams a week of gear is a complete waste, i beleive the pros would know more on this with hands on, but no matter what your fighting against your genetic coding that knows exactly how much muscle it wants on you for homeostasis, anymore and it gets harder and harder and harder......also have to rem they eat like fucking robots, and have all the top of the line drugs also. Kai Greene "the reality is is I eat pounds and pounds of meat everyday....das da fact!"

subs33's picture

Ya, I dont eat as well as that , but ima put that diet plan you gave me in effect starting soon.With my genetic code and that diet plan, I will be growin and das da fact, brotha..lol

You definatly know you shit. You should be higher with karma, with your knowledge. But maybe you just wanna share it with a selected few.. ;)

msus504's picture

thanks alot my dude i appreciate it! anytime!, LOL i hear ya on that brotha!! but i def dont know it all but i do what i can

betheman's picture

Ditto here as well. I've been doing this for about 1.5 years. Curious how long you have been doing this protochol?

I've wondered this same thing....how much truth is in the whole receptor theory...and how that effects us on TRT.

good topic.

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JSS's picture

Awesome article but wouldent cutting back calories 300 below maintenance for 4 weeks after your cycle be really bad for trying to keep gains after the cycle? I am guessing this would not be nessecarry for someone after there first cycle but when would you really need to clear up your receptor sites, 2nd or 3rd cycle? Also when would you really know when your receptor sites are all full up?