+ 18 Clearing Your Receptors 101
Clearing Receptors 101
A lot has been said in regards to clearing the receptors and I thought now would be a good time to delve into this subject and simplify things.
Basically, one must view the receptor sites as parking spaces.
Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger, fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the cook, who would in-turn make the food and the waitress would then bring the food to you and you would then begin eating which is the whole reason you came to the hamburger stand in the first place.
I think everyone can easily understand that. Which means everyone can easily understand all they need to know about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and explain what happens when you inject steroids
Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can place them they must first find a parking space.
Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the system because they previously only dealt with what your body naturally produced. However, there are lots of extra parking spaces that can be utilized and so the steroids park themselves into these spaces.
Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!
The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of "DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the receptor spaces, if they are already taken up by old "dead cars" you are shit out of luck.....
This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors parking space.
This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in new muscle mass!
O.K. Trevor, I am with you so far, but what the f*** can I do about it?
The answer is ...PLENTY!
First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is "too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars" you will have sitting in the receptor parking spaces which means NO MORE GROWING!
Now with this in mind, how can we help get the cars out of there?
Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time in this situation which is why it is important to utilize short courses that will cause less disturbance in the system, less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up the spaces.
That being said, it should be noted that even short course will pile up "dead cars" after a while and you should give yourself an extended clean out of 2 months at least once a year.
But Trevor, isn't there anything I can do to help speed the process?
Once again the answer is yes!
You can help speed the process up dramatically by increasing your metabolic rate...Speeding up the metabolic rate is akin to hiring extra tow trucks to clear out all those "dead cars" that are occupying the receptor sites!
Have you ever know a person who was much, much fatter than you and yet ate half as much?
These poor bastards think they were given the genetic shaft and try every diet fad imaginable only to stay fat. Their problem no longer lies in their eating habits--which is ironic--; it lies in their metabolism, which basically was shut down due to the excess eating and lack of exercise that got them fat in the first place. Once you understand this, you can easily control your weight for the rest of your life. But what the f*** does this have to due with steroid receptor sites?
EVERYTHING!
The same thing I would prescribe someone whose metabolism has shut down due to obesity, is the same thing I would prescribe someone who's receptor sites are all clogged and is no longer making progress....INCREASE THE METABOLIC RATE!!
Below I will outline a few ways this can be achieved in the constraints of a 4 week Receptor Clearing Cycle follwing the completion of a Muscle Building Course using anabolics:
Diet: I suggest cutting back 300 calories below maintenance per day during a 4 week off time from your anabolic regime...I also suggest eating 6-8 small meals spread out from early morning to late at night. The higher the number of meals you eat, the more your body has to go to work and break down the food which causes the metabolic rate to increase.
Aerobics: Yet another tool in the battle to increase the metabolism, I would suggest low level aerobics 5 times per week 30 minutes per session.
Pharmacology: It is important that one does not have ANY anabolics that are active in the system during this time period.....make sure that you have had a good 4 weeks since your last shot of long acting compound before you embark on this 4 week receptor clearing cycle....otherwise you are wasting your fucking time! That being said, I would suggest the use of the following compounds to help accelerate the Receptor Clearing Process:
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D.N.P.-- Understand that this is a fucking vicious poison and a component in T.N.T., and I do not suggest it's use at all, but to be fair I must admit that NOTHING can raise the metabolic rate like D.N.P. can. Because this is well known, there are many people that will want to try it...This being the case, D.N.P. should only be used in the following manner during this course: 3 days on, 4 days off at a dose of 4mg per kilogram of bodyweight taken before bed----have plenty of towels around and a fan to keep you cool!
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Cytomel--T3 is another booster of metabolic rate which is why the fitness models live on this stuff...it keeps you engines running high and burns the fat right off....In this case, we are more concerned with the fact that it increases the metabolic rate. Suggested use is 75mcg -100mcg 5 days on 2 days off for the 4 week course
- If you do not wish to use D.N.P.---which I think is the smarter approach as it is very dangerous.
There you have it...a brief simple lesson on your receptors and how you might go about keeping them free and clear so you can continue to Grow, Grow, Grow and they begin to go to work.
SOURCE:
Smith, T. (2010, February 04). Steroid Receptor Clearing. Retrieved January 17, 2012, from isteroids: http://www.isteroids.com/steroids/Steroid%20Receptor%20Clearing.html
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Awesome article but wouldent cutting back calories 300 below maintenance for 4 weeks after your cycle be really bad for trying to keep gains after the cycle? I am guessing this would not be nessecarry for someone after there first cycle but when would you really need to clear up your receptor sites, 2nd or 3rd cycle? Also when would you really know when your receptor sites are all full up?
It doesn't mean shit. Not to be critical of whoever wrote this, but it's a bunch of broscience bullshit that's been shot down by a number of prominent people in the steroids community, like bill roberts.
There's no such thing as "dirty" receptors. The only reason bigger dudes need more gear is because they are bigger. If i stick a 140lb kid on 500mg of test for 8 weeks, of course he is going to explode compared to a guy who is already 200lbs from years of training.
Great article! It seems to go against conventional practice with regards to the T3 however. Most people will only take T3 on an AAS cycle due to the (apparently) extremely catabolic nature of T3. Do you have any suggestion for that?
Also, the oft-paired with clenbuterol wasn't mentioned. Would you use this for clearing as well?
PS: I know you didn't write this but just wanted everyone's thoughts on the matter.
I have to be honest, I don't think you understand AAS. Just doing a set of squats will reduce androgen receptor content in the quads by 46%. Too much broscience, not enough pub med citations.
"Androgen receptor content did not change one hour following the single set [of squats] but significantly decreased by 46% following the multiple set. Increasing the volume of resistance exercise significantly affects acute metabolic and hormonal responses. In addition, the higher volume of resistance exercise resulted in a reduction in androgen receptor content in skeletal muscle one hour post-exercise possibly due to greater protein catabolism associated with the higher level of stress."
Ratamess, N. A., Kraemer, W. J., Volek, J. S., Maresh, C. M., Van Heest, J. L., Rubin, M. R., French, D. N., Sharman, M. S., Vescovi, J. D., & Silvestre, R. (2004). Effects of heavy resistance exercise volume on post-exercise androgen receptor content in resistance-trained men. Medicine and Science in Sports and Exercise, 36(5), Supplement abstract 1659.
Its all about AMPK and mTOR. There's a long pathway for muscle hypertrophy. mTOR is the common "intersection" that all synthesis must go through. If you see mTOR expression, protein synthesis is occurring. Anabolic steroids increase mTOR activity, showing increase in synthesis. AMPK is the opposite, it the metabolic sensor of cell energy. It starts increasing from not eating, and is further increased by exercise. Eatign kills it. AMPK keeps cancer cells from growing, inhibits storage of fat in adipose tissue, increases lipolysis, decreases insulin resistance (increases sensitivity), and promotes immune system activity.
This is the theory behind intermittent fasting. One eats a few hours before exercise (because fasted cardio has been shown to not burn any more fat, because oxidation is the limiting agent, and nitrogen balance is reduce by 2x). Then exercise, then binge eat for next 8 hours (mTOR peaks at 5 hours, showing maximum synthesis, and slowly declines over the next few days). Then fast until noon the next day when I eat again right before exercise. This skyrockets AMPK, and all its positive effects, and still builds muscle after the workout (which is maximized because AMPK maximizes insulin sensitivity). You are losing muscle during the fast, but if you gain say 3% muscle in the binge, then lose 1% muscle in the fast, you're net gain is still positive.
Check out AMPK and mTOR. All the answers are in those two.
Not to be critical, but steroids are lipophilic; this means they diffuse through the cell membe. Once inside the cell, steroids interact directly with cytoplasmic receptors; these hormone-receptor complexes then diffuse into the nucleus and act as transcription factors, which bind to DNA and serve as the orders to begin protein production. CAMP has nothing to do with the process.
Plus, down-regulation is a decrease in the net number of these nuclear receptors, limiting the maximal response. It is not "sitting on the receptor and doing nothing", because sitting on a receptor is called stimulation, duh.
Can you say that again but use the burger, car park analogy
I wish it was that easy! I give props to the writer for creativity, regardless of the technical mistakes
great post bub...
I beleive that the clearing and over saturation receptor theory is purely anecdotal at best regarding AAS. This thinking goes along with the popular and false theory that as an AAS user gets more experienced that they need more AAS to make gains which is emphatically false. When someone takes AAS at a particular dosage you will make gains until you hit a plateau. Now you can do 2 things at this point, increase your dosage of AAS to push past this plateau in which you will inevitably hit another plateau and so on.. or you can keep that same AAS dosage and maintain that particular plateau that you have reached. I find it hilarious when people say that there bodies have become desensitized to a particular AAS and need more to make gains... Its all relative biological physics in which you need more AAS to push past your gained/maintained plateau.
The only things that in your body that is scientifically proven to become desensitised/burned out is your CNS (central nervous system) and Thyroid. The over use of stimulants such T3, ephedra, caffeine, Dnp, clen, etc... can severly impare ones CNS and possibly even destroy a thyroid gland.
Bill Roberts (not wanker anthony roberts) also shot down the "saturated receptors" myth in a series of articles he wrote for mesoRX
If receptor over saturation was possible, your body would've stopped responding to it's master hormone a long time ago, which makes zero sense.
The only reason guys have more trouble gaining weight on later cycles than they did their first cycle, is simply because they are bigger on subsequent cycles than when they first started.
Exactly!
Can you specify the references of studies that show that the receivers can saturate please?
Great post that was my 5 th time I read it!
Great Read! Very helpful...
Question..... Say if someone was on for six months, what should pct look like along with cleaning receptors?
Awesome post. Wow.
jasonhit would. curious as to hows it work for ya? been looking i havent gotten much out of current cycle and wondering how to clean recepters on trt was thinking of going prop route
Thanks for the info
awesome thread! great info!
Is that 4 week period start right after last injection?
Or its 4 week after pct?
Thanks for the post, usefull
dnp burn fat and muscle!!and this method suggest take dnp.its good for metabolism, but solo -you will lose muscle.
crazy ridiculous maddening respect for you right now, great branding.
jasonhGreat info, just curios about us trt guys( i never did steriods till put on trt then said screw it lets see how big i can get) do ya suggest following same protocall? i havent been completly off in 9 mons notice when i ramped up current cycle not getting much results probley from clogged recepters. just dont look forward to a return to how i felt before put on trt. also how bout clen for metabilism?
Im on trt also and had the same sentiment.Good question Im curious as well
jasonhdoesnt look like were going to get a reply maybe ill try dinasor longe
Wow, Great read and a lot of info in an easy to read post. Dont see that often, thanks!
If I knew how Id give you points too.. I know I know Damn noob
Something I never understood about androgen receptors is can their number be increased? What if they're naturally low in your case? Can that even be measured? I've been reading a lot about this subject recently and some studies seem to suggest that training can increase their number, others say that consuming AAS upregulates them in number (if only that were true) and bodybuilding supplements manufacturers maintain that certain supplements like ginger, zinc and L-carnitine help keep them "clean".
interesting point. Wonder how much genetics plays into this? My guess is "a lot".
run t3 or dnp with no other compounds for 4 weeks? pass. interesting post though.
Wait what? off time? You mean I cant run tren forever, ah fuck that sucks
Great post USP, but I have a question, what if your a guy like me who already has an extremely fast metabolism? Does that mean I don't even have to worry about any of this per say? I mean granted, im not gonna get cocky and overload on roids just becuz I do have a fast metabolism, but I should be ok in terms of my receptors clearing out on their own right?
lol brother i would still abide by this unitl i find a research or a case study of some sort. I will start researching this and get back to you =)
Ok cool, thx USP
Good read. I'm glad I came across this.
thank you bro
Anonexcellent post USP
Thank you =)
One thing to watch out for with this is the fact that using a metabolic enhancer like t3 will rip away hard earned muscle along with fat, it doesnt care. From all of my reading its always suggested to be running a form of aas when on this even if anavar/winny (which i know defeats the purpose of this thread).
beavisNow that's the kind off thing eroids is here for. great read!
THIS is the type of posts that merit rep points guys.
Well done...+2
thank you brother
Thank you guys.
So how long should you cycle for? Everybody says to run test 10 to 14 week at least? Little confused. Some good info though
Sending on the cycle I still run 10-12 weeks unless I have boldenenone then I run that for at least 14-16 weeks.
AnonVERY,VERY informative... Thank you.
Give them a vote if you find it helpful.PermalinkThank you bro
Great write up. I mean GREAT too.
Thank you brother