Heres what I found works best for me. I start with heavy incline on smith machine. Then go to narrow hammerstrength presses. Then to incline dumbbell fly’s. Like rusty said do the V at first being hardest, then fly straight out to side.. once cant fly anymore hold the dumbbells together elbows in and do incline presses to failure. Once cant do anymore presses keep dumbbells together and arms locked straight, let your shoulder blades drop down then squeeze up. Relaxing and flexing blades, isolating chest. This has been beneficial for me

6'2" @ 280 @ 22%bf.... Bro ur a massive dude. Imo, if u was to lower ur bodyfat ur chest wld pop. From my experience, the upper chest and shoulders fat is the first to go. Maybe cut to 15-18% range and see what ur truly working with. I'm gonna have to try this reverse barbell grip. what the guys have said below is my normal routine (with great results), but sometimes u have to change it up to keep the body from getting complacent..

Cable flys are all you need. Hit them with purpose and squeeze the hell out of the muscles. 4 sets 8-16 rep range twice a week blow my chest up. It’s the secret no one talks about.

Just build up a big flat bench - once you can do 405 for several reps you'll have a big chest all over.

EDIT: I've just seen your avatar and you are already Bloody Massive!! What exactly is the problem? LMAO

Have you tried wearing wrist wraps? Also how do you execute your reps, try cable flies where you do 3 second holds at top of the movement, then a slow release.