posted Wed, 12/17/2025 - 07:33
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Nandrolone + Yk-11
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I've been an avid user of nandrolone since my second cycle, using it as my main compound with a moderate testosterone base. As of recent i've been curious about injectable yk-11, however studies do indicate that one of the properties of yk-11 is an inhibitory effect on 5a-reductase which outcompetes T/DHT. As a result, I've been curious to see if users of this AAS pair might have experienced significant hair loss/other effects of a lack of DHN conversion arising from yk-11 much like fin/dut?
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Some people have hair loss because it behaves like a dht but is truly not a dht because it lacks a molecule that all dht drugs have. It's actually a 19 nor. But the only problem with sarm and steroid cycles is that sarms have much higher binding affinity to the androgen receptors so they kick off regular roids. The best thing to do with a swarm cycle is run low test like 200-300mg weekly because anything higher than that is just being kicked right off the receptor and converting to estro. I have run a few inject yk cycles. Used to be my favorite compound but it seems to not work the more times you use it. Like I got 2 crazy cycles out of yk and 1 that was good. Other than it's been duds, idk if I just wasn't getting real yk during the bad cycles(using same sources). But I think it has more to do with it can only lower follostatin(forget exactly what it does) so much before it stops working.
Interesting about SARM's binding tighter to the AR mate
The synthetics always hit the receptors harder because they were scientifically made to. Literally the name SARM they Selectively target the Androgen Receptors to minimize side effects(Modulate)(I didn't know where to put the M in at haha. But literally sarms were made as a steroid replacement so it didn't affect the prostate and other things. Basically they were made for old people or for people with muscle wasting diseases to try and combat prostate problems because I think early on the prostate danger was overblown so they wanted to try and find replacement for test and other legally prescribed steroids.but they just never put them thru all the clinical trials they needed cuz they started seeing it wasn't replacing natural test and it wasn't as selective as they thought so they scrapped the whole sarm concept. Like lgd 4033 actually almost made it to the pharmacy. Out of any sarm, that went to phase 3 trials I believe( the final ones I think) and companies even sued over the trademark name(I think). Viking therapeutics owns the rights to lgd 4033 and it's actually still listed as a Investigational New Drug so it still has the potential to become a real med.