G/LHRH Agonists
I was reading a thread at the World Class Bodybuilding Forum about Kryptocur (see Kryptocur - World Class Bodybuilding Forum) and it got me thinking that it could be used to prevent HPG suppression instead of just for pct.
During a cycle, the hypothalamus detects circulating T and E2 and secretes less (if any) GnRH. Subsequently, the pituitary is not stimulated to release gonadotropins (i.e. pituitary shutdown). And without gonadotropins, the testes shut down (no T, no spermatogenesis).
In theory, one could keep the entire HPTA stimulated by using GnRH while on steroids. The idea would not be to get the testes to produce T in significant levels, but rather to prevent the HPTA from shutting down.
GnRH injections aren't practical because of the very short half life. However, GnRH nasal spray (Kryptocur) addresses the problem of short half life: as directed, it is supposed to be used 3 times a day, one spray in each nostril. Each spray contains .2 mg of GnRH. That's 1.2 mg of GnRH per day. I have no idea how appropriate this dosage is for purposes other than inducing testicular descent in boys with cryptorchidism, which is what Kryptocur is actually indicated for.
Kryptocur is legitimate; you can find plenty of studies on it validating its effectiveness (kryptocur - Google Scholar), although it is not available in the US (its used in Europe).
The only form of HPG shutdown that would be possible while using GnRH would be hypothalamic shutdown. While I've heard of primary hypogonadism and secondary hypogonadism (hypogonadotropic hypogonadism) resulting after the cessation of steroid use, I've never heard of tertiary hypogonadism (hypothalamic hypogonadism) resulting from it. Any thoughts? Has anyone ever tried using Kryptocur on a cycle to prevent shutdown ?
Company's that do L/GnRH
Suprefact Nasal Spray......Buserelin acetate
Synarel 60 Nasal Spray.....Nafarelin acetate
Decapeptyl 0.1mg ..... Triptorelin acetate
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I have looked into this as well and there is just too limited research on its long term efficacy. Secondary hypogonadism can occur and is actually one of the main uses for GnRH agonists. It is used to prevent early puberty and prostate cancer by shutting down the HPTA. A small dose has shown to increase testosterone production but long term use desensitizes the pituitary can causes what amounts to chemical castration.
The ONLY obscure study I have read about uses battery powered pumps to give multiple ultra low dose GnRH.
I personally have some triptorelin myself BUT I only have it as an absolute last resort from a failed recovery. There just isn't enough data to support long term use of such drugs.
Here is a study for the use of GnRH in males:
http://press.endocrine.org/doi/full/10.1210/jc.2002-020518
Cheers for that buddy I'll get reading! I've been reading quite abit about it lately, it seem like it could be a next generation med for pct protocol but the one thing that sticks out the most is the dosage which if not done right could fuck you up for life.... I can see in the future that this compound will do more harm than good if people don't take the time to seriously read up on this compound.
Peptide sources should keep well away from GnRH compounds.
Yea I have read the same thing about dosing. It appears that it needs to be very personalized with constant monitoring by professionals. The other issue I have read about is that mimicking the natural pulsation of the hypothalamus is near impossible. Also there just isn't any real science behind it being used to reboot the HPTA. And I don't see pharmaceutical companies wanting to spend money on researching it. It seems they are focused on SARMS atm. For the pharmaceutical companies why make a drug that will be used for a short time and last for a long time when you can make a drug that one has to take every day for the rest of his life. I know that's going out on a bit of a tangent but I just don't see anything other then broscience being used to determine if it is effective or not for what we do.