We all know that on cycle we want to control estrogen. Too much estrogen can lead to a host of factors including increasing SHBG, water retention, GYNO, emotional symptoms, etc. On the other hand, we do not want to destroy estrogen, because too little estrogen and we suffer from stiff joints, loss of sexual desire, lowered muscle gains etc. It should also be well known that when running either deca and tren that one should control prolactin. Many choose to use caber or prami to do this. High prolactin in males can lead to lactating nipples, and with estrogen can cause GYNO. Also high levels of prolactin or hyperprolactinemia can lead to loss of libido, insulin resistance, decrease Testosterone and make you feel like a zombie,(apathetic, carless). This is all done by Glutamate and GABA. GABA increases, and for those of you that do not know what GABA is, its the hormone in your brain that makes you feel calm. On the Flip side, most people would think that men do not need prolactin, considering its a female lactating hormone, Well they are wrong! Low levels of prolactin, just like low levels of estrogen cause side effects as well. Low prolactin or hypoprolactinemia has been linked to male infertility, due to prolactins effect on leydig cells, LH and FSH, ED, premature ejaculation, and anxiety, again because GABA is lower and glutamate is higher. NOW I am writting this in hopes that I can help somebody out. I am about 2 1/2 weeks into my first 19 nor cycle, I am running NPP at 450 mgs a week, and test at 650 mgs a week. I frontloaded the NPP and can deff feel the effect in my joints and strength, however the past week I have had loss of libido and extreme Calmness, almost zombie like feel. I LOVE to go to the gym and workout, and yesterday I wasn't feeling it at all, I had shoulders and tris which I like doing, but I wanted no part of it, didn't care if I was big or small, fat or skinny, just didn't give a shit, almost like a "whatever happens happens" attitude, and that's not me! I am never and I mean NEVER an ultra calm person. Thats when I knew something was wrong, it was almost like I was depressed but not sad, if that makes sense, really weird feeling. I am taking Pharma Grade caber at .5 mgs a week( .25 split into two doses monday and friday) NOW after countless hours of research and reading a member on here called MegaT883 post, I am pretty sure my prolactin is high. I do not have lactating nipples, but I am too fucking calm, not giving a shit attitude in the gym that I would NEVER have. I hope reading this people understand that prolactin just like estrogen needs to be controlled for healthy sexual function and mental function along with a host of other things. Also I will be getting blood work and I feel that is truly the best thing to do when you are unsure what is happening. We play with hormones guys, our shit gets outta whack, its extremely important we try to keep what we can and want in range!