.25e3d is strong so use bloods to keep in check. If bulking then keep it towards 52 max e2 level. You can adjust it downward towards 25 if needed. Over the next 3 weeks e2 will move up as esters cleaved. Alex hold e2 following a half life so towards pct might run adex to 2nd week pct. Rebound... Raised e2 halts pct so there's the reason why. Says try so id run it at 3 weeks past cycle. Hgh after cycle will save mass and help axis balance.

This...

https://www.eroids.com/forums/hgh-peptides/rhgh/hgh...born-again

Not sure if you supplement with DIM but this stuff has helped me a lot with water retention which is the only side I have with elevated e2 @69

DIM (Diindolylmethane) is a compound produced when your body digests cruciferous vegetables like broccoli, cauliflower, Brussels sprouts, and cabbage.

DIM is often used in an attempt to improve estrogen metabolism.

What DIM may do

• Encourages the liver to metabolize estrogen into certain metabolites that are generally considered less estrogenic.
• May help some people with mild symptoms of elevated estrogen.
• Can sometimes improve feelings of water retention or estrogen-related mood changes.

I take 300mg daily and it helps considerably I try to avoid use of an AI as much as I can and this seems to do the trick

Good question, and the timing of your bloodwork actually matters a lot for answering it, so let me frame this right before giving you the arimidex call.
Your E2 of 66 is from BEFORE the blast. You pulled these Thursday, which is right as you're starting the 500mg so this reading reflects your 220mg run, not where you're headed. That's important: 66 is the starting point, and now that you've more than doubled your dose (220 to 500), your E2 is going to climb from there over the next few weeks as the higher test aromatizes and the cyp builds toward new steady state. So you're not deciding whether to medicate an E2 of 66 you're deciding what to do as your E2 rises from 66 to wherever 500mg takes you. The number you have is already outdated for your current dose.
Should you start arimidex now? No and here's the reasoning.
Don't start it preemptively, for a few reasons. First, your E2 at 66 is only mildly elevated and you're currently asymptomatic (the crying and itchy nips from February already resolved once your body adapted good sign, that was the initial adjustment, not an ongoing problem). Starting an AI when you're symptom free and only mildly high risks overshooting and crashing your E2, which brings its own misery (achy joints, killed libido, flat mood, worse lipids). Second and this is the timing issue your test levels are still climbing toward the new steady state on 500mg. Cyp takes weeks to plateau (it around takes 5 half-lives), so your E2 hasn't even reached where it's going to settle yet. Starting an AI now means chasing a moving target before you know where it lands. You'd be guessing.
What I'd actually do wait, watch, and let your scheduled bloods guide you.
You've got bloods scheduled for the 30th, which is well timed by then your 500mg will be closer to steady state and you'll see where your E2 actually settles. So the smart play is: hold the arimidex for now, watch for symptoms as your E2 climbs over the next few weeks, and use the 30th bloodwork to see your real on-blast E2. Start the AI based on symptoms and that bloodwork, not preemptively on a pre-blast reading.
The symptoms to watch for as your E2 rises.
Since you've already felt your early signals, you know your tells the itchy nips especially are your early estrogenic warning (and an early gyno sign worth respecting). Watch for those coming back, water retention and bloat (which tends to show up around the pecs more than elsewhere when E2 runs high, based on what a lot of guys report), the emotional stuff returning, or puffy nipples. If those start showing up as your dose climbs, that's your cue. One note on using erections as a gauge: poor erections can signal either high or low E2 depending on the person, so don't judge direction by that alone pair it with your other symptoms (specially if cialis can’t help out, that’s a bad sign).
If or when you do start the arimidex start gentle, do NOT crash it.
This is the key. When symptoms or your 30th bloods tell you it's time, start at 0.5mg EOD (every other day) not more, not daily. Take that, assess how you respond over several days, and adjust the following week based on symptoms and or bloods. The mistake to avoid is hitting it hard and crashing your E2 to the floor crashed estrogen feels as bad or worse than high (joints, libido, mood, lipids all suffer), and estrogen is protective, you need it in range, not zero. So titrate gently and give your body time between adjustments. Your nolva is good to have stashed too if you ever get actual gyno symptoms (lump, soreness) rather than just high-E2 bloat, nolva (a SERM) is the tool for that, since it blocks the estrogen receptor in breast tissue directly, whereas the Arimidex prevents the E2 rising in the first place. Different tools for different jobs.
One honest aside on the bigger picture.
You went from 220 to 500 in one jump more than doubling. That's a big step, and it's why your E2 is going to climb meaningfully and why you're right to be thinking about managing it. Just know that the rapid dose increase is what tends to bring the sides on (not just E2, acne, hair, etc.), so watch yourself over these next few weeks as your body adjusts to the much higher dose, and let the bloodwork keep you honest about where things actually are.
Bottom line, don't start the arimidex now your E2 of 66 is a pre blast reading, you're asymptomatic, and your test is still climbing toward steady state on the new 500mg, so medicating now means chasing a moving target and risking a crash. Instead, hold the AI, watch for symptoms (itchy or puffy nips, pectoral area bloat, the emotional stuff) as your E2 rises over the next few weeks, and use your scheduled bloods on the 30th to see where your E2 actually settles on-blast. Start arimidex only if symptoms develop or the bloods show it's needed and when you do, 0.5mg EOD, assess, adjust slowly, don't crash it. You've got the right tools on hand (arimidex for E2, nolva for actual gyno) and bloods scheduled at a good time just let those guide you rather than pre-medicating on an outdated number.