+ 3 Esters
I'm sure you have noticed the similarities on the labeling of many drugs. Let's look at testosterone for example. One can find compounds like testosterone cypionate, enanthate, propionate, heptylate; caproate, phenylpropionate, isocaproate, decanoate, acetate and the list goes on and on. In all such cases the parent hormone is testosterone, which had been modified by adding an ester to its structure. One of the most misunderstood subjects in the world of steroids is the ester.
An ester is a chain composed primarily of carbon and hydrogen atoms. This chain is typically attached to the parent steroid hormone at the 17th carbon position (beta orientation). Esterification of an injectable anabolic/androgenic steroid basically accomplishes one thing: it slows the release of the parent steroid from the site of injection.
By slowing the release of the parent steroid the compound would remain active in the body for a very short period of time.
Different esters exist for various compounds. Different esters give compounds different clearance times in the blood. All over the internet, you will find different (unreferenced) information on the half-life of compounds. A lot of the confusion comes from a lack of understanding on a compound's half-life versus it's biological or terminal half-life. For our purposes, we really only care about the terminal half-life, defined as:
*The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic, physiologic, or radiologic activity, as per the MeSH definition.
Ester Half-life Terminal Half-life
Suspension within 1 hour
Acetate 3 days 1 day
Propionate 2 days 0.8 days
Phenylpropionate 4.5 days 1.5 days
Butyrate 2-3 days
Valerate 3 days
Hexanoate 3 days
Caproate 4-5 days
Isocaproate 9 days 4 days
Heptanoate 5-6 days
Enanthate 10.5 days 4.5 days
Cypionate 6-7 days 5 days
Octanoate 6-7 days
Nonanoate 7 days
Decanoate 15 days 7.5 days
Undecylenate 8-9 days 14 days
Undecanoate 16.5 days 20.9 days
IMPORTANT NOTE: These half-lives are approximations, and may vary slightly depending on injection site, carrier oil, and other factors. There isn't any pharmacokinetics studies done on the majority of AAS.
Long chain esters, such as Cypionate, Decanoate, Enanthate, etc. possess a much heavier molecular weight than short chain esters. Consequently, on a mg for mg basis, you are receiving far extra mg of steroid in a short estered compound as opposed to a large estered compound.
Listed below is the percentages of the actual hormones for each ester:
Ester % Of The Actual Hormone
Acetate 87%
Propionate 80%
Phenylpropionate 66-67%
Isocaproate 72%
Enanthate 70%
Cypionate 69%
Decanoate 62%
Undecylenate 61%
Undecanoate 61%
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jayiskI only learned about ester weight about 2 yrs ago. I had never heard of it until my friend told me.
So then if someone is running 500 mgs of Testosterone Enanthate a wk they are really only getting 350 mgs of test?
or am i misreading something?
PcushionYour math is correct. Still though don’t look that deep into it. Even pros base their dose of the common of total weight. No one ever says I am consuming 500mg of actually testosterone a week. They always say 500mg test e.
Nice nice nice
What's actually more interesting, is their peak times
You'd be surprised
PcushionCrazy interesting. In regards to testosterone e and c it’s fascinating is that eugonadal men have a much higher peak, which makes sense. The most interesting piece to me is that hypogonadal men do not peak as high as eugonadal men but the curve is much smoother in terms of decline. Both groups do peak in 24-48 hours post injection with cyp and enth esters.
https://www.fertstert.org/article/S0015-0282(16)46108-X/pdf
Yup and it can be less than the 24, metabolism, site, individual etc
Then, for me at least, I weigh up short vs mid ester peaks, anabolism versus sides... hell throw pain into the mix....
Decision done
PcushionExactly!!!
Have that info handy?
Get yourself some Behre and Nieschlag for testo
Or med lit on comparative pharmacokinetics of esters
Andrology or testosterone? I was able to find the 1998 version used for $30 on amazon, think that’ll do the trick over the $100-200 newer versions?
Want a softcopy? Can share both...
That would be fantastic!
Send an FR, send an anon mail and all yours fella
basskiller89I"m lost, I think test e can be closer to 10 days??
PcushionIt takes the body roughly 1 day to remove 1 carbon from the ester. Metabolism and injection site can cause this to vary. Average is 6-8 days with anything +/- that being an outlier. I fall around the 5 day mark.
basskiller89Makes sense, I go by the bloodwork too
Helpful post. As to the accuracy of it a few guys below have questioned it.
I made a post similar to this a while back explaining the process
https://www.eroids.com/forum/steroids-qa/anabolic-steroids/test-esthers-...
Also you based percentages without any given variable, is that per 100mg?
Some of your numbers are off.
Based on 100mgs we get this...Champion of the mind worked on this as well as myself so I found his faster than mine.
Testosterone Acetate: 83mg
Testosterone Propionate : 80mg
Testosterone Enanthate : 70mg
Testosterone Cypionate : 69mg
Testosterone Phenylpropionate: 66mg
Testosterone Decanoate: 62mg
Testosterone Undecanoate: 61mg
Nandrolone Cypionate: 69mg
Nandrolone Phenylpropionate: 63mg
Nandrolone Decanoate: 62mg
Nandrolone Undecylenate: 60mg
Trenbolone Acetate: 83mg
Trenbolone Enanthate: 68mg
Boldenone acetate: 83mg
Boldenone Propionate : 80mg
Boldenone Cypionate : 69mg
Boldenone Undecylenate: 61mg
Drostanolone Propionate: 80mg
Drostanolone Enanthate: 71mg
Methenolone Acetate: 82mg
Methenolone Enanthate: 71mg
basskiller89Boom!!
Thanks bro, I have been googling my ass off trying to find he % of actual hormone with the given esters.
PcushionYour half life and terminal life is incorrect. If carbon chains are responsible for half lives then how is it’s possible that enanthate and cypionate both have 8 carbon chains yet you label cypionate as having a ester half life 3.5 days shorter than enanthate which is not true cypionate is slightly longer acting. Then go on to say the cypionate etser has a larger weight than enanthate ( which is true, it is heavier by a small amount) thus making it longer acting. Acetate 2 carbon chain faster removal shorter half life. Propionate ester 3 carbon chain longer half life than acetate. You label the exact opposite. Decanoate 10 carbon chain much shorter than undecylenate yet you label it longer. Also undecylenate and Undecanoate do not weigh the same.
Yup x2
You are correct, the difference between cyp and enanthate is only maybe a half a day to a day longer in length, not the opposite.
PcushionWhat he did was just copy and past some bad information off the internet.
RustyhookerNice list!