http://www.nejm.org/doi/full/10.1056/NEJMoa1206168?query=featured_home&

According to a new study just published in the New England Journal of Medicine, lowering estrogen levels is bad for men as well. Estrogen plays important roles in metabolism, sex drive, and brain health and low levels will hurt all of these things. One of the key issues that this leads HRT practitioners to consider is avoidance non converting testosterone analogs and taking great care with SERMS.