Hey bros,

i wrote this one day ago for some nice members here on eroids who needed some info on t3 and they thought this could be useful for the community, so i post it here in it's own thread. It is copy and paste free and my english is not the best so please forgive me for some grammar fails etc.

The pharmaceutical manufactured name for the thyroid hormone triiodthyronine (T3) is liothyronine. The thyroid Hormone is not directly produced from the thyorid. The thyroid produces only levothyroxin (T4) which is not directly active in the Body. It must first be enzymatically converted to T3. T3 regulates the oxidative metabollism. The oxidative metabolism can be defined as the burning of nurtients for the purpose of energy extraction. This metabolisation happens in the mitochondria ("the powerhouse of the cells") whereby ATP is built. ATP acts as a chemical girder for the produced energy and is the muscles primary energy supplier for their contraction. T3 is the clearly more effective thyroid Hormone of the thyroid hormones. It is four times superior to the Thyroxin (T4). Athletes use the liothyronine usually in the last 4-8 weeks before competition to reduce their body fat to the lowest percentage possible.

It increases the metabolic rate by speeding up the metabolization of carbs, protein and fat and by building more ATP from these macronutrients. By this effect the athlete benefits from highly increased fat burning. The higher energy consumption is partially based on enhanced cardiovascular effort which means basically that the heart beats faster and stronger. Alone through this effect a third of the ATP is depleted. A further effect of a raised thyroid hormone level is based on the enhanced production of so-called decoupling protein in the mitochondria. These proteins decouple the ATP synthesis from the breathing and causes the energy production in the mitochondria to be more inefficent. Inefficient means in this case that more energy is released in the form of heat and is "lost" because it is not used to produce more ATP. That causes that, even while sitting around idle, a much higher amount of calories is burnt. Another interesting point is that the intake of T3 raises the production of HGH. Since somatropin also induces fat burning, this effect could be another way of T3 to enhance it's fatburning features.

According to the strength of the liothyronine it is important to be very careful with this compound. If the user does not provide enough muscle protection with highly androgene steroids or the HGH muscle loss is predetermined.Many athletes use t3 together with Clenbuterol as muscle protection which is not useful because Clenbuterol does not have anticatabolic effects in the human body in the usual dosage (if you want to know why i can text you). But it has another fat burning effect. Studies have shown that T3 increases the amount of beta-2-receptors by what the effectiveness of clenbuterol and other beta-receptor-antagonists like ephedrine is enhanced.

Suitable Steroids for this purpose would be: Stanozolol, Trenbolone, Testosterone Propionat. These compunds are highly muscle protective and complement each other.

The intake amount and the lenght of the cycle should not be exaggerated in any case. Against the widespread opinion in fact there is no threat of permanent damage or hypothyroidism but the cardiovascular burden and the interaction in combination with other substances like Clenbuterol or ephedrin must not be ignored.

For a long time it was common for Bodybuilder to use 25-50mcg t3 daily to be able to eat a higher amount of calories. Thereby a faster muscle growth is reported. The idea behind this practice is that the thyroid hormone speeds up and improves the metabolization of protein [..]. So t3 appeals slightly anabolic. But considering to the before mentioned side effects this is not adviseable.

Another group of people who use t3 are bodybuilder who take HGH. In this case the daily dose is 25-50mcg to provide the higher t3 needs while on a hgh cycle. This is not recommendable because T3 has shown to reduce the nitrogen storage caused by somatropin.

As you can easily see now, liothyronine is absolutely nothing for beginner. Beginner should always take safer medicaments as ephedrine (ECA-Stack etc.)...

Dosage and intake:

Usually Bodybuilder start with one 25mcg tablet in the morning and increase the dose by another 25 mcg tablet every 3-4 days until the maximum dosage (100-150mcg) is reached.

Due to the halflife of 19 hours one single intake in the morning is possible but it is more adviseable to split in 2 or three doses for a better compatibility of the stomach and a more constant drug Level. Do not eat or drink any nourishments which are high in calcium two hours before and after the intake because calcium binds thyroidhormones in the alimentary canal and inactivates them.

if you want to take T3 to cover your higher needs while on HGH you usually take 10-25mcg a day which is enough. But as above mentioned this is not recommendable.

To discontinue t3 it's the same as above. You decrease the dosage every 3-4 days by 25 mcg, at the and you can take a half tablet before you are at zero. This will be enough time for the thyroid to reuptake its production. Some experts recommend not to discontinue and just stop the intake after the desired result is reached becaus the thyroid will reuptake it's production shortly, even after a longer-range intake. Although this fact is true, it is advisable to discontinue after the pattern above because it allows a fluent Transition.

Sideeffects:

Disturbance, tension, sweating, insomnia, weightloss (...), diarrhea, cardio-vascular Problems, cardiac insufficiency, Exhaustion, bone loss, myasthenia, Libido loss, erectyl disfunction, gyno.

Females additional: oligoarthritis, amenorrhoe.

The permanent damage or hypothyoridism can be counted as another Bodybuilding legend. A healthy thyroid will reuptake it's normal production even after intake for years.

Sorry for bad english if you couldn't understand something just tell me and i'll try to rewrite it better. Hope you could get some useful Information.

Sources:

G. Löffler and P. E. Petrides, Biochemie und Pathobiochemie, Berlin: Springer, 2006.
http://onlinelibrary.wiley.com/doi/10.1002/food.19810250432/abstract

T3 negates hgh anabolism
1: J Hepatol. 1996 Mar;24(3):313-9. Related Articles, Links
Effects of long-term growth hormone (GH) and triiodothyronine (T3) administration on functional hepatic nitrogen clearance in normal man.
Wolthers T, Grofte T, Moller N, Vilstrup H, Jorgensen JO.
Department of Medicine M (Endocrinology and Diabetes), Aarhus University Hospital, Denmark
http://www.ncbi.nlm.nih.gov/pubmed/8778198

"triijodthyronin" by chemiDplus
http://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=DBMaint...

Hypothyreose: Substitution mit T4 und T3, german medicinal journal
http://www.aerzteblatt.de/archiv/17270

Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPAR{alpha} dependent manner.Andrew C Adams, Inna Astapova, Ffolliott M Fisher, Michael K Badman, Katherine E Kurgansky, Jeffrey S Flier, Anthony N Hollenberg, Eleftheria Maratos-Flier
http://www.sigmaaldrich.com/catalog/papers/20236931

datasheet 3,3′,5-Triiodo-L-thyronine Sigma-aldrich
http://www.sigmaaldrich.com/catalog/product/sigma/t2877?lang=de&region=AT

BMS Anabole Steroide - Das Schwarze Buch 2010
http://www.amazon.de/Anabolde-Steroide-Neue-schwarz-Neuauflage/dp/B0018P...