+ 2 The DIM Experiment - Blocking E2 is Old School on TRT
DIM (Diindolylmethane) has gotten some traction for helping people with high estrogen to potentially lower it.Unfortunately after digging further into DIM myself for this same reason (I personally don't use an Al when onTRT, when on cycle I will try to use other compounds to control my estrogen but if needed I will take aromisin). I did blood work to test the theory over a couple months.The results might not be what you were hoping. Two major issues come with DIM that are very important to consider before taking this supplement.
Side note:
DIM is not an Al or a serm and does not act like either. It works by regulating estrogen metabolism.
This helps process your estrogen into less potent forms.To simplify you have "bad" estrogens (16a-hydroxyestrone) and "good" estrogens (2-hydroxyestrone).
THE REAL TRUTH ABOUT DIM
If you're reading this because you're on the fence with taking DIM this is probably the only part you care about. While this supplement might help metabolize estrogen and help down regulate the estradiol in your body the benefits might not out weight the cons. DIM is not an anti estrogen but it is an anti androgen. 100mg a day to 450mg a day have been used in trials and the results show that DIM competitively blocks dihydrotestosterone (DHT) from binding to androgen receptors, preventing its activation and translocation to the cell nucleus, thereby suppressing androgen-dependent gene expression, like prostate-specific antigen (PSA). It essentially works as a natural plant-derived androgen receptor antagonist, inhibiting testosterone's active effects, which can help with hormonal acne, PCOS, and potentially prostate issues by reducing androgen activity. If your taking testosterone this supplement is going to compete with the androgens/testosterone. This means you are essentially putting a supplement in your body that is going to fight against the testosterone and out compete it for receptors. Pretty much doing the exact opposite of why your taking the test in the first place, your blocking it! If you know or have used HGH it's like taking a few IUs then hammering a bowl of mash potatoes right after.
Now for the blood work. I will dig up my labcorp but the results of taking 300mg 1x a day for a few months showed to bring my estrogen down a bit from roughly 82 to mid 70s. Now was this due to it regulating my estrogen? Maybe. Or was it due to the fact that DIM was binding to some of my androgen receptors thus blocking some of the testosterone from being “used”. Less active testosterone less aromatization. So in my opinion I think the slight decrease in my estrogen was simply from the fact that I lost some of my test dose to the DIM. Now if your on a low dose of TRT and your estrogen is slightly high and YOUR GETTING SIDES then maybe a dose of 100mg once a day would just be enough to help you out. Estrogen shouldn't be treated based on numbers but how you feel. If your not on cycle then you should be taking a dose that agrees with you and for someone like me I can live with 80-85 e2 with 0 side effects. I don't bother to regulate those numbers but we are all different.
BLOCKING E2 is Old School - ON TRT NOT ON CYCLE
I know estrogen is a controversial topic. I think a lot of old school body builders have pushed blocking estrogen for so long that everyone is just blinded by the new school findings. I will post some links below of some doctors I follow. Some are legit specialists others are TRT clinics. I’m not here to force you to do anything or try to tell you which is right or wrong. If your not on cycle and your just using TRT I don’t think anyone needs an AI. Between injection freq, dosage, and body comp I think estrogen can be “controlled” naturally and the whole everyone should have a range of 30-50 is outdated. Don’t be scared of the estrogen if you have no sides. I along with many of my buddy’s have estrogen between 60-90 and non of us have issues. Now you might and that’s ok! If you do maybe back off the dose a bit or try more injections.
Links
https://youtube.com/shorts/QbvUiG1BZB0?si=9ztAsnGFeW6xvpAk
https://youtube.com/shorts/FrFWEFB2DSo?si=ZXtsGmjVTYDXBP5k
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Interesting information on E2/Estrogen. I was surprised to see TRT blends that’ll include an AI with Test. Seems to me you would need to be taking a lot of test for that to have any potential value and then it’s not really TRT.
Ya I have noticed them popping up and I actually have a vial of straight arimidex (5mg/ml). It hits totally different. This was when I first started and thought I needed to constantly keep my e2 under 40. Then after speaking with multiple doctors I just learned if it’s not causing issues to not even worry about it. I ended up feeling worse chasing a number than I did just letting it take its course. Obviously you have limits but to think it needs to be 30-60 all the time is not the case for everyone. I feel amazing around 80-85 with 0 symptoms. I actually started getting nipple sensitivity when I first started and I freaked out. I had this younger doctor who was also into training and he said a lot of people will get nipple sensitivity when they first started TRT naturally from your hormones adjusting and it doesn’t always mean your just getting gyno symptoms. He told me to hold out for 3-4 weeks and wait it out. Against my better judgement I listened to him and he was 100% on the money. All sensitivity went away and I was fine with no AI.
100%
More Plates More Dates on YouTube has some really good videos on estrogen and not using AI.
I tried dim for a couple weeks or a month or so a while back and it for real made my poops so Big that taking a dump was a life changing experience. Never again...
Lmao might have to add that to my research, I thought for sure that would be a plus for you? No? I like a good dump . Nothing like tickling my prostate with a logger
Nah man this was like trying to shit out a 40oz old English. Was real bad.
Oh man Iv had one of those. That’s when it stands up out of the water. Like that one South Park episode where Randy shits into the sky
No they weren't even impressive. Just super thick. I wonder if anyone else has ever had that happen. It was from like nature's best or something brand.