+ 11 anti estrogen affects IGF1 level
preface
Since my product godtropin landed on eroids, more and more members gave a try, and more and more blood tests came out, among those tests, gh serum: higher level is around 33, average level is around 25, lower level is around 18. And IGF1 level, highest is 662, lower is around 400, average is around 500. So far, the blood test are pretty good. And plus, more and more clients leave their real experience on my si page. They can feel the sides from gh, such as deep sleep, swollen hands, joint pain etc, and they get result after a few weeks, such as fat loss, faster recovery etc, and no one complain the quality of my gh
Problem came out
One of my client always share his real experience with my gh, he can feel the sides, he can see the result on his body, and he assumes that its high quality gh, and he is very satisfied with this gh.
One day he said to me that he would run a blood test, he feels great with this shit, he had confidence that he could get very high IGF1 level. But after he got the result of the blood test, he was depressed, his IGF1 is only around 90.he couldn’t believe it, coz he feel this shit works very well on him, but whats wrong with the IGF1 ? he showed this to me, I got shocked as well. Coz he use 10iu per day, it must be something wrong with it. So I asked him what he was taking during the time. So he told me some stuffs that he was taking
Research
With his labs and his stuffs he is taking, I asked some guys who are much more experienced on hgh, all of them think that it should be anti estrogen stuff that affect the IGF1 level.
So I started to research the anti estrogen and IGF1,then I found some studies about this
GH (Growth Hormone) is like a master hormone for tissue growth and fat regulation due to its own intrinsic qualities and its propensity to be converted into or trigger the production and release of Growth Factors. Of these Growth Factors, one of the best known in regard to muscle growth is IGF-1 (Insulin-Like Growth Factor-1).
As most are aware by now, IGF-1 is a powerful anabolic and anti-catabolic hormone. Whether in pre-contest mode or packing on the mass, the amount of circulating and stored IGF-1 an athlete maintains plays a powerful role in the results achieved. Obviously as IGF-1 levels decrease so does the potential for packing on the beef, and the amount of lean tissue lost during calorie-restricted periods increases as well.
check this out:
https://www.eroids.com/forum/steroids-qa/pct-anti-estrogens/anti-estroge...
The negative of tamoxifen's action in the liver is its ability to suppress production of the peptide hormone IGF-1. IGF-1 is broken down from growth hormone and is considered to be more potent than growth hormone itself for the purposes of building muscle tissue. High IGF-1 levels make a big contribution to the process of building a better physique and the ability of tamoxifen to suppress IGF-1 levels is another reason why tamoxifen use tends to be disappointing for the purposes of building muscle mass. In fact, a recent study which showed a rise in total testosterone (they failed to measure free testosterone or levels of SHGB) and a reduction in IGF-1 levels after tamoxifen usage is a significant indicator as to why it can prove disappointing for the building or maintenance of muscle mass.
Check this :
http://www.predatornutrition.com/en/content/issues-with-using-tamoxifen-...
Tamoxifen did not affect basal GH secretion, but it decreased circulating IGF-I in 14 patients (82%) by an average of 90 ± 4 mcg/L, (p = 0.005), and normalized plasma IGF-I in 8 patients (47%). Total and bioavailable testosterone levels increased in all evaluable men (n = 8). Tamoxifen was well tolerated.
Check this :
http://www.ncbi.nlm.nih.gov/pubmed/24243064
Conclusion:
Anti estrogen stuff affect a lot the IGF1 level. But the conversion of hgh to igf is only a small aspect of the benefits of hgh. You still can get benefits of the fat loss ,anti aging ,better recovery and good sleep etc But the amount of cell proliferation will be minimized due to the lack of igf. To counter this you would have to administer insulin with the hgh so that igf can form in the liver. But this is only necessary if the goal of using the hgh was muscle gain. Otherwise fat loss wont be affected and most people wouldnt even notice unless they had bloods to prove. Its a very small difference. Almost unnoticeable. Thats likely why he thought he would get 550 on igf.
Suggestion:
1, So guys, if u r on PCT, pls don’t waste your money on IGF1 test.
2, In cases where a result is low, that's when you need to do the other test....so low gh serum, you need get igf1 to be able to analyze. Low igf1, you need get gh serum to analyze. They can both be effected. But often we will see 1 number low and the other high which indicates something effected the low result. Although if both low, it's still possible something effected both but very helpful to get both in those scenarios. ..that's why I proposed to get both tests done.
This is from my research and my opinion, if u guys find something wrong, pls let me know, Im glad to correct it.
Sorry for my poor English. Hope u guys could understand .
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very interesting information. shows how much I truly do not know. onward to more research
Check this out. Let me know what you guys think.
http://www.mesomorphosis.com/articles/rea/aromatase-inhibitors.htm
So is it safe to go with letro or armidex then?
Damn I thought Letrozole and Arimidex increase igf-1. My understanding was serms are the bad guys. I'm running 1250 mg test ew right now. Was about to start on arimidex. Guess I'll hold off for now until I know more.
Good job matt nice work! What batch was that kit from?
first batch, he ran it for around 18 days, and the labs was one month ago.
Even with the use of large amounts of ais on 10ius ed igf-1 should be very high. 90 is a baseline number meaning that kit was either bunk or got ruined during transport.
he started with low dose,then just jumped into 10iu, but he felt sides and he got good result. that kit is just a random kit ,i couldnt be a bunk, got ruined during transport, it could be.
I have to agree with irongame. Nolva will drop IGF-1 90 ng/ml but not 200+. (I'm being conservative and thinking at the dose he stated his IGF-1 should of reached at least 290 ng/ml.)
I remember I had a member he tested IGF-1after a long PCT of 6 wks and ran nolva at 20-30mg during PCT. His bloods showed IGF-1 at 111L flagged and he was 23. Refrence range was 115-355. But of course he was not on HGH. See what I'm saying.
Here's the other thing did you know that women have higher HGH and also IGF-1 levels. DO you know why.. they have more estrogen.
https://www.eroids.com/forum/general/general-talk/estrogen-and-gh-igf-1
https://www.eroids.com/og/the-bloody-truth/estrogen
Igf increases during use of armidex, or so this study says
Also noted from other studies that letrozole has a boost effect to igf 1 in post menopause breath cancer patients
Let the debates begin
http://www.ncbi.nlm.nih.gov/pubmed/11983488
Snip
Abstract
Insulin-like growth factors (IGFs) play a fundamental role in cancer development by acting in both an endocrinal and paracrinal manner, and hormone breast cancer treatments affect the IGF system by modifying circulating growth factor levels. We evaluated total IGF-1, IGF-2, IGF binding protein (IGFBP)-1 and IGFBP-3 in the blood of 34 postmenopausal advanced breast cancer patients (median age 63 years, range 41-85) treated with anastrozole, a non-steroidal structure aromatase inhibitor (NSS-AI). The plasma samples were obtained at baseline, and after 2, 4, 8 and 12 weeks of treatment. The IGFs were quantitated by means of sensitive radioimmunoassays (RIAs). IGF-1 significantly increased during anastrozole treatment (baseline versus 12 weeks, P=0.031), IGF-2 showed a trend towards an increase, and IGFBP-1 constantly but not significantly decreased; IGFBP-3 did not seem to be affected at all. The anastrozole-induced changes in IGFs and IGFBP-1 appeared to be different in the patients receiving a clinical benefit from those observed in non-responders. We have previously shown that letrozole (a different type of NSS-AI) modifies blood IGF-1 levels, and the results of this study of the biological effects of anastrozole on the components of the IGF system confirm our previous observations.
pls also check this study
https://www.eroids.com/forum/steroids-qa/pct-anti-estrogens/anti-estroge...
Will do.
BTW this is the most info a source has posted on his product that I have seen in quite a long time.
thanks bro, i think the source should have more responsibility to sacrifice for this community
ZandaAnother great article! Thanks for pointing this one out, Matt! Really sheds some light on the different types of AIs and their effect on igf-1
ZandaWow - very interesting. I had read somewhere (in a medical
journal) that the igf suppression/reduction of gains) may be linked to tamoxifen specifically but im happy to see that arimidex may have the opposite effect since that is the AI I'm running.
Btw- thx for accepting FR, this was going to be my exact question!
http://press.endocrine.org/doi/full/10.1210/jc.2010-1477
Snip
Conclusions: Tamoxifen, but not raloxifene, reduces IGF-I levels. Both SERMs stimulate the gonadal axis, with tamoxifen imparting a greater effect. We conclude that in therapeutic doses, raloxifene perturbs the GH and gonadal axes to a lesser degree than tamoxifen.
thanks for the info, bro
Thanks brother very interesting!
ZandaMatt, very good read! Much appreciated. Quick question: i see the article focuses on tamoxifen (brand name Nolvadex), but do the same principals of igf suppression apply to anastrozole (brand name arimidex)?
as i know, for all anti estrogen stuff, they should have the same principals of suppression on IGF1, more or less.
I have been looking into it all week since I first read that there may be some negative effect on igf.
Check the link I posted above
thanks for the info Matt, it will help a lot of people!
Good read, English isn't an issue
I will be looking deep into funding a natural anti estrogen here in the future. Thanks for your work on this
Now that's the kind of response I was looking for. My dude! Thanks Matt!
my pleasure to provide some useful info to help some guys out
Very good info matt ,thanks for clearing that up ,I was wondering myself about pct and igf levels,
yeah,i hope this info could help some people here, coz at he beginning, i was confused as well, why some guys got so low igf1 ,meanwhile they feel good results with hgh.